eif4e
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  • Official Full Name
  • eukaryotic translation initiation factor 4E
  • Background
  • Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
  • Synonyms
  • EIF4E; eukaryotic translation initiation factor 4E; CBP; EIF4F; EIF4E1; EIF4EL1; MGC111573; eIF-4E; OTTHUMP00000219701; OTTHUMP00000219702; OTTHUMP00000219703; OTTHUMP00000219704; OTTHUMP00000219705; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1
Cat.#:Eif4e-5107MTag:His
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Eif4e Protein, His-tagged
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Cat.#:EIF4E-3198HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF4E Protein, GST-tagged
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Cat.#:EIF4E-2373HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Eukaryotic Translation Initiation Factor 4E, GST-tagged
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Cat.#:EIF4E-2775HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4E, His-tagged
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Cat.#:EIF4E-2050HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4E protein
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Cat.#:EIF4E-26389THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4E protein, His-tagged
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Cat.#:EIF4E-4840HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Eukaryotic Translation Initiation Factor 4E, GST-tagged
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Cat.#:EIF4E-5106MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF4E Protein
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Cat.#:EIF4E-2066RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF4E Protein
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Cat.#:EIF4E-1428RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EIF4E Protein, His-tagged
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Cat.#:EIF4E-6651HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EIF4E 293 Cell Lysate
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Involved Pathway

EIF4E involved in several pathways and played different roles in them. We selected most pathways EIF4E participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alpha6-Beta4 Integrin Signaling Pathway, Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
EIF4E; EIF3K; EIF1AX; EIF4EBP1; EIF4A2; EIF2S1A; EIF4EB; EIF2S3; EIF4H; EIF1AXA
Alpha6-Beta4 Integrin Signaling Pathway
YWHAQ; PLEC; NTN1A; SMAD3B; CDKN1A; EGFR; EIF4E; RTKN; CD151L; COL17A1
Antiviral mechanism by IFN-stimulated genes
EIF4A2; EIF4G2A; NUP50; EIF4G1; IFIT11; EIF4G2; NUP35; USP18; HERC5; ARIH1L
BDNF signaling pathway
FRS2; KCNN2; EGR1; IGF2BP1; MAP3K2; CDKL5; EEF2; FRS3; CSNK2A1; EIF4E
Cap-dependent Translation Initiation
EIF4A1; EIF2B1; EIF2S1; EIF4B; RPL35; EIF4E; EIF3K; EIF2S1A; EIF1AXA; EIF5
Cytokine Signaling in Immune system
TRIM22; EIF4G2A; EIF4A1; EGR1; GHRB; IFIT8; TRIM10; JAK1; TRIM5; SPRED3
Deadenylation of mRNA
PAIP1; EIF4G1; EIF4B; EIF4A2; TNKS1BP1; EIF4E; EIF4A1; D1BWG0212E; C2orf29; EIF4EB
Deadenylation-dependent mRNA decay
DCP1B; EIF4A2; EIF4E; EIF4G1; EIF4A1; DDX6; TNKS1BP1; DCP2; D1BWG0212E; LSM6

Protein Function

EIF4E has several biochemical functions, for example, RNA cap binding, enzyme binding, eukaryotic initiation factor 4G binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4E itself. We selected most functions EIF4E had, and list some proteins which have the same functions with EIF4E. You can find most of the proteins on our site.
Function
Related Protein
Function RNA cap binding
Related Protein EIF4E; SNUPN; EIF4E2; LARP1; EIF4G3; NCBP2; EIF4A1; NCBP1
Function enzyme binding
Related Protein LUC7L2; PYCARD; BIRC5; HMGA1; HINFP; KIAA1967; PRKCE; ESR1; ZFHX3; ABCD1
Function eukaryotic initiation factor 4G binding
Related Protein EIF4E
Function poly(A) RNA binding
Related Protein PABPN1; USP10; MBNL1; PUF60; SNRPA; MRPL37; ERI3; MKRN2; RPS6; RPS21
Function protein binding
Related Protein MAPKAPK5; CDA; GAN; EEF1A1; RBP5; PPP1CB; ARNT; UBL4B; NLRP2; TMEM93
Function repressing transcription factor binding
Related Protein HDAC9; RUNX2; KAT5; PRDM5; HDAC4; DDX20; CTBP1; PARK7; HDAC1; SRI
Function translation initiation factor activity
Related Protein EIF3JB; EIF2A; EIF2D; EIF1AY; EIF3S10; EIF3HB; EIF3F; EIF3HA; EIF2S1B; EIF4A1B

Interacting Protein

EIF4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4E here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4E.
EIF4EBP1; EIF4ENIF1

EIF4E Related Articles

Moodley, V; Naidoo, R; et al. Screening of pepper (Capsicum annuum L.) lines for resistance to an isolate of Potato virus Y (PVY) occurring in KwaZulu-Natal (KZN), Republic of South Africa. CROP PROTECTION 68:36-40(2015).
Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).