Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

EIF4E

  • Official Full Name

    eukaryotic translation initiation factor 4E

  • Overview

    Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
  • Synonyms

    EIF4E; eukaryotic translation initiation factor 4E; CBP; EIF4F; EIF4E1; EIF4EL1; MGC111573; eIF-4E; OTTHUMP00000219701; OTTHUMP00000219702; OTTHUMP00000219703; OTTHUMP00000219704; OTTHUMP00000219705; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF4E-2775H Recombinant Human EIF4E, His-tagged E.coli His
Human EIF4E-2050H Recombinant Human EIF4E protein E.coli N/A 2-217
Human EIF4E-2373H Recombinant Human Eukaryotic Translation Initiation Factor 4E, GST-tagged E.coli GST
Human EIF4E-3198H Recombinant Human EIF4E Protein, GST-tagged Wheat Germ GST
Human EIF4E-6651HCL Recombinant Human EIF4E 293 Cell Lysate HEK293 N/A
Human EIF4E-2922H Recombinant Human EIF4E Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF4E-4287HF Recombinant Full Length Human EIF4E Protein, GST-tagged In Vitro Cell Free System GST 217 amino acids
Human EIF4E-2054H Recombinant Human EIF4E Protein (Met1-Ile118), N-His tagged E.coli N-His Met1-Ile118
Human EIF4E-1001H Recombinant Human EIF4E Protein (M1-V217), Tag Free E.coli No tag M1-V217
Human EIF4E-41H Recombinant Human EIF4E Protein Complexed With m7GTP (1-217) E.coli 1-217 a.a.
Human EIF4E-40H Recombinant Human EIF4E Protein Complexed With EIF4G (1-217), N-His tagged E.coli N-His 1-217 a.a.
Human EIF4E-1002H Recombinant Human EIF4E Protein (M1-V217), His tagged E.coli His M1-V217
Human EIF4E-39H Recombinant Human EIF4E Protein (1-217), N-His tagged E.coli N-His 1-217 a.a.
Mouse EIF4E-5106M Recombinant Mouse EIF4E Protein Mammalian Cell His
Mouse EIF4E-2718M Recombinant Mouse EIF4E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EIF4E-2718M-B Recombinant Mouse EIF4E Protein Pre-coupled Magnetic Beads HEK293
Mouse Eif4e-5107M Recombinant Mouse Eif4e Protein, His-tagged E.coli His
Mouse Eif4e-811M Recombinant Mouse Eif4e Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat EIF4E-2066R Recombinant Rat EIF4E Protein Mammalian Cell His
Rat EIF4E-1723R Recombinant Rat EIF4E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF4E-1723R-B Recombinant Rat EIF4E Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EIF4E-1428R Recombinant Rhesus monkey EIF4E Protein, His-tagged Mammalian Cell His
Rhesus Macaque EIF4E-1252R Recombinant Rhesus Macaque EIF4E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EIF4E-1252R-B Recombinant Rhesus Macaque EIF4E Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF4E Related Articles
  • EIF4E Related Signal Pathway

EIF4E involved in several pathways and played different roles in them. We selected most pathways EIF4E participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alpha6-Beta4 Integrin Signaling Pathway, Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SEIF2S1A;EIF4E;EIF4B;EIF4G1;EIF4EB;EIF4A2;EIF4H;EIF4EBP1;EIF4A1
Alpha6-Beta4 Integrin Signaling PathwayEIF4E;SMAD3B;CLCA1;EIF4EB;CDKN1A;DSP;DST;CD151L;CD151
Antiviral mechanism by IFN-stimulated genesJAK1;NUPL2;NUP50;KPNA5;UBE2L6;EIF4A1;EIF4E3;DPF1;EIF4G2
BDNF signaling pathwayCSNK2A1;GNB2L1;CDH2;EGR2;EEF2;YBX1;EGR1;FRS2;CNR1
Cap-dependent Translation InitiationFAUB;EIF3K;EIF4A1;EIF2S3;EIF4E;EIF5;EIF1AXA;EIF4G1;EIF2S1A
Cytokine Signaling in Immune systemCSH1;TRIM8;TRIM62;CRK;FRS2B;EIF4A1;SPTB;PEBP1;TRIM14
Deadenylation of mRNAD1BWG0212E;EIF4E;EIF4A2;EIF4G1;TNKS1BP1;EIF4EB;EIF4A1;EIF4B;PAIP1
Deadenylation-dependent mRNA decayPAIP1;EIF4A1;EIF4A2;D1BWG0212E;DDX6;EIF4G1;EIF4E;EIF4B;EXOSC8

EIF4E has several biochemical functions, for example, RNA cap binding, enzyme binding, eukaryotic initiation factor 4G binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4E itself. We selected most functions EIF4E had, and list some proteins which have the same functions with EIF4E. You can find most of the proteins on our site.

Function Related Protein
RNA cap bindingSNUPN;EIF4E;NCBP2;EIF4G3;EIF4E2;LARP1;EIF4A1;NCBP1
enzyme bindingPRTN3;TSPAN14;NOXO1;SRC;ZNHIT6;HIST1H2AK;PRKCD;TSPAN17;RPS3
eukaryotic initiation factor 4G binding
poly(A) RNA bindingLARP2;MRPS14;RPSA;NOL11;MAGOH;FASTKD3;NKAP;KIAA1324;RBMS2
protein bindingPMP22;CD97;PTPRZ1;RACGAP1;SMC4;SURF1;PRKAR2AA;TTC25;ATP7B
repressing transcription factor bindingTBP;TLE4;HHEX;HDAC7A;TCF3;DDX20;KAT5;CBX5;CTBP1
translation initiation factor activityEIF2S1;EIF4H;EIF4A1B;EIF4G2;EIF3EA;EIF1AY;EIF1AD;MTIF3;EIF2S1B

EIF4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4E here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4E.

EIF4EBP1; EIF4ENIF1

Moodley, V; Naidoo, R; et al. Screening of pepper (Capsicum annuum L.) lines for resistance to an isolate of Potato virus Y (PVY) occurring in KwaZulu-Natal (KZN), Republic of South Africa. CROP PROTECTION 68:36-40(2015).
Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does EIF4E protein expression differ in cancer cells compared to normal cells? 01/28/2022

Cancer cells often exhibit elevated levels of EIF4E expression, leading to increased protein synthesis. This heightened activity is associated with tumor growth and aggressiveness.

Are there any targeted therapies or drugs designed to modulate EIF4E protein activity? 11/22/2021

Yes, researchers are exploring targeted therapies that aim to inhibit EIF4E activity in cancer cells. These therapies hold promise for treating certain types of cancer.

How does EIF4E protein contribute to the development of drug resistance in cancer cells? 07/08/2021

Elevated EIF4E activity in cancer cells can lead to increased synthesis of proteins involved in drug resistance mechanisms. This can reduce the effectiveness of chemotherapy and targeted therapies.

Can EIF4E protein levels be used as a diagnostic or prognostic marker for cancer? 03/05/2021

Yes, elevated EIF4E expression has been observed in some cancer types and is being investigated as a potential diagnostic and prognostic marker. However, further research is needed to establish its clinical utility.

Apart from cancer, are there any other diseases where dysregulated EIF4E protein has been implicated? 10/23/2020

Yes, dysregulated EIF4E expression has been associated with neurological disorders and viral infections. Researchers are studying its role in these diseases to explore potential therapeutic interventions.

Customer Reviews (3)

Write a review
Reviews
02/20/2019

    researchers highly recommend the EIF4E protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.

    02/09/2017

      Researchers can rely on the EIF4E protein's specificity and sensitivity to obtain accurate and reliable results.

      07/10/2016

        The EIF4E protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.

        Ask a Question for All EIF4E Products

        Required fields are marked with *

        My Review for All EIF4E Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends