EIF4E
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Official Full Name
eukaryotic translation initiation factor 4E
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Overview
Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. -
Synonyms
EIF4E; eukaryotic translation initiation factor 4E; CBP; EIF4F; EIF4E1; EIF4EL1; MGC111573; eIF-4E; OTTHUMP00000219701; OTTHUMP00000219702; OTTHUMP00000219703; OTTHUMP00000219704; OTTHUMP00000219705; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- EIF4E Related Articles
- EIF4E Related Signal Pathway
EIF4E involved in several pathways and played different roles in them. We selected most pathways EIF4E participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alpha6-Beta4 Integrin Signaling Pathway, Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF2S1A;EIF4E;EIF4B;EIF4G1;EIF4EB;EIF4A2;EIF4H;EIF4EBP1;EIF4A1 |
Alpha6-Beta4 Integrin Signaling Pathway | EIF4E;SMAD3B;CLCA1;EIF4EB;CDKN1A;DSP;DST;CD151L;CD151 |
Antiviral mechanism by IFN-stimulated genes | JAK1;NUPL2;NUP50;KPNA5;UBE2L6;EIF4A1;EIF4E3;DPF1;EIF4G2 |
BDNF signaling pathway | CSNK2A1;GNB2L1;CDH2;EGR2;EEF2;YBX1;EGR1;FRS2;CNR1 |
Cap-dependent Translation Initiation | FAUB;EIF3K;EIF4A1;EIF2S3;EIF4E;EIF5;EIF1AXA;EIF4G1;EIF2S1A |
Cytokine Signaling in Immune system | CSH1;TRIM8;TRIM62;CRK;FRS2B;EIF4A1;SPTB;PEBP1;TRIM14 |
Deadenylation of mRNA | D1BWG0212E;EIF4E;EIF4A2;EIF4G1;TNKS1BP1;EIF4EB;EIF4A1;EIF4B;PAIP1 |
Deadenylation-dependent mRNA decay | PAIP1;EIF4A1;EIF4A2;D1BWG0212E;DDX6;EIF4G1;EIF4E;EIF4B;EXOSC8 |
EIF4E has several biochemical functions, for example, RNA cap binding, enzyme binding, eukaryotic initiation factor 4G binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4E itself. We selected most functions EIF4E had, and list some proteins which have the same functions with EIF4E. You can find most of the proteins on our site.
Function | Related Protein |
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RNA cap binding | SNUPN;EIF4E;NCBP2;EIF4G3;EIF4E2;LARP1;EIF4A1;NCBP1 |
enzyme binding | PRTN3;TSPAN14;NOXO1;SRC;ZNHIT6;HIST1H2AK;PRKCD;TSPAN17;RPS3 |
eukaryotic initiation factor 4G binding | |
poly(A) RNA binding | LARP2;MRPS14;RPSA;NOL11;MAGOH;FASTKD3;NKAP;KIAA1324;RBMS2 |
protein binding | PMP22;CD97;PTPRZ1;RACGAP1;SMC4;SURF1;PRKAR2AA;TTC25;ATP7B |
repressing transcription factor binding | TBP;TLE4;HHEX;HDAC7A;TCF3;DDX20;KAT5;CBX5;CTBP1 |
translation initiation factor activity | EIF2S1;EIF4H;EIF4A1B;EIF4G2;EIF3EA;EIF1AY;EIF1AD;MTIF3;EIF2S1B |
EIF4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4E here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4E.
EIF4EBP1; EIF4ENIF1
- Q&As
- Reviews
Q&As (5)
Ask a questionCancer cells often exhibit elevated levels of EIF4E expression, leading to increased protein synthesis. This heightened activity is associated with tumor growth and aggressiveness.
Yes, researchers are exploring targeted therapies that aim to inhibit EIF4E activity in cancer cells. These therapies hold promise for treating certain types of cancer.
Elevated EIF4E activity in cancer cells can lead to increased synthesis of proteins involved in drug resistance mechanisms. This can reduce the effectiveness of chemotherapy and targeted therapies.
Yes, elevated EIF4E expression has been observed in some cancer types and is being investigated as a potential diagnostic and prognostic marker. However, further research is needed to establish its clinical utility.
Yes, dysregulated EIF4E expression has been associated with neurological disorders and viral infections. Researchers are studying its role in these diseases to explore potential therapeutic interventions.
Customer Reviews (3)
Write a reviewresearchers highly recommend the EIF4E protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.
Researchers can rely on the EIF4E protein's specificity and sensitivity to obtain accurate and reliable results.
The EIF4E protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.
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