EIF4G1 Protein, eukaryotic translation initiation factor 4 gamma, 1


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Official Full Name eukaryotic translation initiation factor 4 gamma, 1
Background The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Synonyms EIF4G1; eukaryotic translation initiation factor 4 gamma, 1; P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1; eukaryotic translation initiation factor 4 gamma 1; EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G;
    • Species :
    • Human
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4G1-1387H Recombinant Human EIF4G1 Protein (1250-1599 aa), His-tagged Yeast His
    Human EIF4G1-477H Recombinant Human EIF4G1 Protein (1250-1599 aa), GST-tagged E.coli GST
    Human EIF4G1-12383H Recombinant Human EIF4G1, His-tagged E.coli His
    Human EIF4G1-28550TH Recombinant Human EIF4G1, GST-tagged Wheat Germ GST
    Human EIF4G1-479H Recombinant Human EIF4G1 Mammalian Cell His
    Human EIF4G1-545HCL Recombinant Human EIF4G1 cell lysate N/A

    EIF4G1 involved in several pathways and played different roles in them. We selected most pathways EIF4G1 participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4G1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA8; PSMD9; PSME3; PSMD10; HNRNPD; EIF4G1; PSMD14; PSMD5
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF4G1; EIF4E; FAUB; EIF2S1A; EIF2S1; EIF4EBP1; EIF4EB; EIF4B; EIF2S3; EIF1AXA
    Antiviral mechanism by IFN-stimulated genes USP18; NUP50; UBE2L6; IFIT12; IFIT11; EIF4E3; NUPL2; IFIT14; KPNA5; HERC5
    Cap-dependent Translation Initiation EIF4E; EIF2S1A; EIF2B1; EIF3K; EIF5; EIF4G1; EIF4EB; EIF2S3; EIF4H; FAUB
    Cytokine Signaling in Immune system CSF2; ARIH1; XAF1; SPTA1; FGF8B; SPNA1; GBP4; IFI27; RASGRP4; CRK
    Deadenylation of mRNA D1BWG0212E; PAIP1; EIF4A2; EIF4B; EIF4EB; EIF4E; TNKS1BP1; EIF4A1; C2orf29; EIF4G1
    Deadenylation-dependent mRNA decay EIF4E; EIF4EB; EXOSC8; DCP2; C2orf29; EIF4B; EIF4A1; DDX6; PAIP1; DCP1B
    Eukaryotic Translation Initiation EIF1AXA; EIF4H; EIF2S1; EIF2B1; EIF4A1; EIF2S3; EIF4B; EIF5; FAUB; EIF4A2

    EIF4G1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4G1 itself. We selected most functions EIF4G1 had, and list some proteins which have the same functions with EIF4G1. You can find most of the proteins on our site.

    Function Related Protein
    eukaryotic initiation factor 4E binding DDX3X; EIF4EBP3; EIF4EBP2; EIF4EBP1; EIF4EBP3L; EIF4G1; GRA; OTX2; HHEX; ANGEL1
    poly(A) RNA binding DDX18; PCSK9; RPL21; SSBP1; CPEB3; HOXB6; UTP3; RPS18; DUT; ZYX
    protein binding ABCG8; POLE4; GAB1; WIPF2; SUV39H2; APC; CCNE1; RXRG; PLK1; SNIP1
    translation factor activity, RNA binding EIF2S3; ABCF1; EIF4H; CPEB3; PPP1R2P9; MTIF3; EIF4A1; EIF4G2; CPEB1A; EIF4G3
    translation initiation factor activity EIF4H; EIF3F; GTPBP1; EIF3S10; EIF3S6IP; EIF4A2; EIF3JA; EIF4E2; EIF4E1C; EIF2S3Y

    EIF4G1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4G1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4G1.


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