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EIF4G1

  • Official Full Name

    eukaryotic translation initiation factor 4 gamma, 1

  • Overview

    The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
  • Synonyms

    EIF4G1; eukaryotic translation initiation factor 4 gamma, 1; P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1; eukaryotic translation initiation factor 4 gamma 1; EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • B2M
  • JD
  • Myc
  • DDK
  • N/A
  • N
  • Trx
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF4G1-01H Active Recombinant Human EIF4G1 protein, Myc/DDK-tagged HEK293T Myc/DDK
Human EIF4G1-28550TH Recombinant Human EIF4G1, GST-tagged Wheat Germ GST
Human EIF4G1-479H Recombinant Human EIF4G1 Mammalian Cell His
Human EIF4G1-12383H Recombinant Human EIF4G1 protein, His-tagged E.coli His 296-645 aa
Human EIF4G1-545HCL Recombinant Human EIF4G1 cell lysate N/A
Human EIF4G1-2844H Recombinant Human EIF4G1 protein, His-B2M-JD & Myc-tagged E.coli His-B2M-JD & Myc 1250-1599aa
Human EIF4G1-02H Recombinant Human EIF4G1 protein, Myc/DDK-tagged HEK293T Myc/DDK
Human EIF4G1-477H Recombinant Human EIF4G1 Protein (1250-1599 aa), GST-tagged E.coli GST 1250-1599 aa
Human EIF4G1-5398H Recombinant Human EIF4G1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF4G1-2825H Recombinant Human EIF4G1 protein(1061-1180 aa), C-His-tagged E. coli C-His 1061-1180 aa
Human EIF4G1-830H-B Recombinant Human EIF4G1 Protein Pre-coupled Magnetic Beads HEK293
Human EIF4G1-1387H Recombinant Human EIF4G1 Protein (1250-1599 aa), His-tagged Yeast His 1250-1599 aa
Human EIF4G1-12384H Recombinant Human EIF4G1 protein, GST-tagged E.coli GST 296-645 aa
Human EIF4G1-151HF Recombinant Full Length Human EIF4G1 Protein, GST-tagged In Vitro Cell Free System GST 1500 a.a. - 1599 a.a.
Human EIF4G1-2887H Recombinant Human EIF4G1 Protein (Glu557-Lys646), N-His and Trx tagged E.coli N-His and Trx Glu557-Lys646
Human EIF4G1-1009HFL Recombinant Full Length Human EIF4G1 Protein, C-Flag-tagged Mammalian cells Flag
Human EIF4G1-830H Recombinant Human EIF4G1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Eif4g1-2789M Recombinant Mouse Eif4g1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF4G1 Related Signal Pathway

EIF4G1 involved in several pathways and played different roles in them. We selected most pathways EIF4G1 participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4G1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AUF1 (hnRNP D0) binds and destabilizes mRNAPSMA8;PSMD9;PSMD10;PSMD14;PSMD5;EIF4G1;HNRNPD;PSME3
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SEIF2S1A;EIF2S3;EIF4E;EIF4EB;EIF2S1;EIF4A2;EIF4G1;EIF4A1;EIF1AX
Antiviral mechanism by IFN-stimulated genesEIF4A1;NUP50;IFIT10;DPF1;MX2;ARIH1L;EIF4E3;IFIT8;ARIH1
Cap-dependent Translation InitiationEIF4G1;EIF2S1;EIF1AXA;EIF5;EIF4A1;EIF2B1;EIF4H;EIF1AX;RPL35
Cytokine Signaling in Immune systemPRLRB;IRF4;DAB2IPB;HAVCR2;IRF6;FGF8B;CRKL;TRIM48;FGF10B
Deadenylation of mRNAD1BWG0212E;EIF4A1;TNKS1BP1;C2orf29;EIF4B;EIF4EB;EIF4A2;EIF4E;EIF4G1
Deadenylation-dependent mRNA decayEIF4E;EIF4A1;TNKS1BP1;D1BWG0212E;EXOSC8;EIF4A2;EIF4B;LSM6;DCP2
Eukaryotic Translation InitiationEIF4A2;FAUB;EIF2S1;EIF4B;EIF1AXA;EIF4H;RPL35;EIF4A1;EIF4EB

EIF4G1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4G1 itself. We selected most functions EIF4G1 had, and list some proteins which have the same functions with EIF4G1. You can find most of the proteins on our site.

Function Related Protein
eukaryotic initiation factor 4E bindingEIF4EBP3L;HHEX;DDX3X;EIF4EBP1;EIF4EBP3;ANGEL1;OTX2;GRA;EIF4G1
poly(A) RNA bindingDDX47;ERH;RPS19;FBL;RPS25;UPF1;PTCD3;MEPCE;TCOF1
protein bindingSETD6;MYLK2;EDC4;GCG;BMP1;FAM115A;MARK3;RELB;DAG1
translation factor activity, RNA bindingPPP1R2P9;EIF4G2;GTF2H2;CPEB1A;EEF1D;MTIF3;EIF4G1;EIF4A1;EIF2S2
translation initiation factor activityEIF2S3Y;EIF4A2;EIF2D;EIF4G3;EIF4E2RS1;EIF1B;EIF4G2;EIF1AY;GTPBP1L

EIF4G1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4G1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4G1.

EIF4A1; PABPC1; EIF4A2; EIF4E

  • Q&As
  • Reviews

Q&As (6)

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Can EIF4G1 protein be used as a potential therapeutic target? 11/04/2019

Some current findings suggest that EIF4G1 may be a potential target for cancer treatment and other disease treatments. However, research in this field is still relatively early, and more experimental and clinical validation is still needed.

Does mutation in EIF4G1 affect its biological characteristics? 10/29/2019

Mutations in the EIF4G1 protein may affect the assembly and functioning of its translation complex, thereby affecting its biological function in cell physiology and disease processes.

What important cell biological processes is EIF4G1 protein involved in? 06/29/2019

The protein is involved in important cell biological processes such as the formation of translational initiation complexes, mRNA translation, transcriptional regulation, and cell signaling.

Is EIF4G1 protein involved in drug therapy? 05/22/2019

Research on EIF4G1 protein versus drug therapy is still in its infancy, but there are already many studies that show that EIF4G1 protein is very important for drug treatment.

What is the role of EIF4G1 protein in cancer? 04/23/2019

Promotes cancer cell growth, proliferation, and deterioration by facilitating the assembly of transcriptional and translational initiation complexes. Therefore, the researchers now believe that EIF4G1 may be a potential target for cancer treatment.

In which diseases is EIF4G1 protein useful in the diagnosis and treatment? 01/14/2019

EIF4G1 plays an important role in the occurrence and progression of various diseases such as cancer, neurodegenerative diseases and inflammation, and its application in the treatment of these diseases is currently being actively explored.

Customer Reviews (3)

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Reviews
05/19/2021

    The activity is strong, and the protein requires only a small amount to achieve the desired effect compared to other proteins.

    01/29/2021

      Very suitable for biosensors, high sensitivity.

      10/07/2020

        It performs very well in terms of recombinant expression.

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