erap1
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  • Official Full Name
  • endoplasmic reticulum aminopeptidase 1
  • Background
  • ARTS1/Adipocyte-derived leucine aminopeptidase (A-LAP) is a member of the M1 family of zinc metallopeptidases. A-LAP is upregulatable by gamma interferon and trims N-terminal lysine, leucine, tyrosine and asparagines residues when they are not followed by
  • Synonyms
  • ERAP1; endoplasmic reticulum aminopeptidase 1; A LAP; adipocyte derived leucine aminopeptidase; aminopeptidase regulator of TNFR1 shedding; ARTS 1; ERAAP1; KIAA0525; PILS AP; puromycin insensitive leucyl specific aminopeptidase; aminopeptidase PILS; adipo
Cat.#:ERAP1-2119HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERAP1 Protein, MYC/DDK-tagged
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Cat.#:ERAP1-532HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ERAP1 Protein, His-tagged
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Cat.#:ARTS-1-873HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARTS-1 protein, GST-tagged
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Cat.#:ERAP1-5276MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ERAP1 Protein
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Cat.#:ERAP1-2132RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ERAP1 Protein
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Involved Pathway

ERAP1 involved in several pathways and played different roles in them. We selected most pathways ERAP1 participated on our site, such as Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
DZIP3; UBE2F; UFL1; CTSH; KIR2DS2; FGF18B; IGKV1-5; TREML4; CD200R4; MGC174857
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
B2ML; SEC24A; SEC23A; ERAP1; ERAP2
Class I MHC mediated antigen processing &
ASB18; CD207; SPSB1; ASB4; STUB1; UFL1; MKRN1; RNF34; TPP2; RNF220
presentation
ATG7; FBXO44; UBE2E3; TRAF7; ASB18; CTSL2; ASB9; SEC23A; TRIM39; CYBB
Immune System
TLR6; CMTM2A; ASB14; ATP6V1G3; KIF2A; NLRP4B; MX2; SH3RF1; IRF9; KPNA5

Protein Function

ERAP1 has several biochemical functions, for example, aminopeptidase activity, interleukin-1, Type II receptor binding, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERAP1 itself. We selected most functions ERAP1 had, and list some proteins which have the same functions with ERAP1. You can find most of the proteins on our site.
Function
Related Protein
Function aminopeptidase activity
Related Protein LTA4H; Npepo; TRHDE; LAP3; LNPEP; RNPEP; XPNPEP1; DPP9; METAP2A; XPNPEP2
Function interleukin-1, Type II receptor binding
Related Protein ERAP1; IL1RN
Function interleukin-6 receptor binding
Related Protein ERAP1; ADAM17; IL6; PYCARD; CNTF
Function metalloaminopeptidase activity
Related Protein ENPEP; XPNPEP1; ANPEPA; METAP2A; LNPEP; METAP2B; RNPEPL1; ANPEP; Npepo; RNPEP
Function metalloexopeptidase activity
Related Protein NPEPL1; METAP1; LAP3; DPEP2; NUDT16; METAP2B; DPEP1; DPEP3; METAP2A; RNPEP
Function peptide binding
Related Protein ERCC3; GPR37L1; PLOD1; TRHDE; RPS6KB1; PPYR1; QRFPR; PPIB; PPIA; NPFFR2.1
Function protein binding
Related Protein ASAP1; MYO18A; GGA3; ATP2B1; FAM9A; PLOD3; FLOT1; ACAP1; ZNF223; NAA11
Function tumor necrosis factor receptor binding
Related Protein ERAP1; Fasl; TNFSF10L; TNFSF12; TRAF1; TRIM37; TNFSF10; TNFSF13; CD70; TNFSF14
Function zinc ion binding
Related Protein ZCCHC10; TET2; RBM5; NANOS2; NR2F1B; ADAM15; CAR6; BTR09; TRIM12A; BIRC5

Interacting Protein

ERAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERAP1.
IL6R; TNFRSF1A; yapH; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

ERAP1 Related Articles

Smith, JA; et al. Update on Ankylosing Spondylitis: Current Concepts in Pathogenesis. CURRENT ALLERGY AND ASTHMA REPORTS 15:-(2015).
Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).