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Recombinant Mouse ERAP1 Protein (731-930 aa), His-Myc-tagged

Cat.No. : ERAP1-2101M
Product Overview : Recombinant Mouse ERAP1 Protein (731-930 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Immunology. Protein Description: Partial.
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Description : Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity).
Source : E. coli
Species : Mouse
Tag : His-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 28.3 kDa
Protein length : 731-930 aa
AA Sequence : PCVQRAERYFREWKSSNGNMSIPID VTLAVFAVGAQNTEGWDFLYSKYQS SLSSTEKSQIEFSLCTSKDPEKLQW LLDQSFKGEIIKTQEFPHILTLIGR NPVGYPLAWKFLRENWNKLVQKFEL GSSSIAHMVMGTTDQFSTRARLEEV KGFFSSLKENGSQLRCVQQTIETIE ENIRWMDKNFDKIRLWLQKEKPELL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : Erap1 endoplasmic reticulum aminopeptidase 1 [ Mus musculus ]
Official Symbol : ERAP1
Synonyms : ERAP1; A-LAP; ARTS-1; PILS-AP; Arts1; ERAAP; PILSA; PILSAP;
Gene ID : 80898
mRNA Refseq : NM_030711
Protein Refseq : NP_109636
UniProt ID : Q9EQH2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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