Recombinant Full Length Human ERAP1 Protein, C-Flag-tagged

• Cat.No.: ERAP1-665HFL
• Product Overview: Recombinant Full Length Human ERAP1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 107.7 kDa
• AA Sequence: MVFLPLKWSLATMSFLLSSLLALLT VSTPSWCQSTEASPKRSDGTPFPWN KIRLPEYVIPVHYDLLIHAN LTTLTFWGTTKVEITASQPTSTIIL HSHHLQISRATLRKGAGERLSEEPL QVLEHPRQEQIALLAPEPLL VGLPYTVVIHYAGNLSETFHGFYKS TYRTKEGELRILASTQFEPTAARMA FPCFDEPAFKASFSIKIRRE PRHLAISNMPLVKSVTVAEGLIEDH FDVTVKMSTYLVAFIISDFESVSKI TKSGVKVSVYAVPDKINQAD YALDAAVTLLEFYEDYFSIPYPLPK QDLAAIPDFQSGAMENWGLTTYRES ALLFDAEKSSASSKLGITMT VAHELAHQWFGNLVTMEWWNDLWLN EGFAKFMEFVSVSVTHPELKVGDYF FGKCFDAMEVDALNSSHPVS TPVENPAQIREMFDDVSYDKGACIL NMLREYLSADAFKSGIVQYLQKHSY KNTKNEDLWDSMASICPTDG VKGMDGFCSRSQHSSSSSHWHQEGV DVKTMMNTWTLQKGFPLITITVRGR NVHMKQEHYMKGSDGAPDTG YLWHVPLTFITSKSDMVHRFLLKTK TDVLILPEEVEWIKFNVGMNGYYIV HYEDDGWDSLTGLLKGTHTA VSSNDRASLINNAFQLVSIGKLSIE KALDLSLYLKHETEIMPVFQGLNEL IPMYKLMEKRDMNEVETQFK AFLIRLLRDLIDKQTWTDEGSVSER MLRSQLLLLACVHNYQPCVQRAEGY FRKWKESNGNLSLPVDVTLA VFAVGAQSTEGWDFLYSKYQFSLSS TEKSQIEFALCRTQNKEKLQWLLDE SFKGDKIKTQEFPQILTLIG RNPVGYPLAWQFLRKNWNKLVQKFE LGSSSIAHMVMGTTNQFSTRTRLEE VKGFFSSLKENGSQLRCVQQ
  TIETIEENIGWMDKNFDKIRVWLQS EKLEHDPEADATGTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Secreted Protein

Gene Information

• Gene Name: ERAP1 endoplasmic reticulum aminopeptidase 1 [ Homo sapiens (human) ]
• Official Symbol: ERAP1
• Synonyms: ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP
• Gene ID: 51752
• mRNA Refseq: NM_016442.5
• Protein Refseq: NP_057526.3
• MIM: 606832
• UniProt ID: Q9NZ08