ERAP2
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Official Full Name
endoplasmic reticulum aminopeptidase 2
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Overview
Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 -
Synonyms
ERAP2; endoplasmic reticulum aminopeptidase 2; L RAP; leukocyte derived arginine aminopeptidase; LRAP; leukocyte-derived arginine aminopeptidase; L-RAP;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Zebrafish
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ERAP2-304H | Active Recombinant Human ERAP2, His tagged | HEK293 | His | Ala 56-Thr 960 | |
| Human | ERAP2-3439H | Recombinant Human ERAP2 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ERAP2-936H | Recombinant Human ERAP2 | Mammalian Cell | His |
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| Human | ERAP2-2777HCL | Recombinant Human ERAP2 cell lysate | Human Cell | N/A |
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| Human | ERAP2-483H | Recombinant Human ERAP2 Protein, His-tagged | E.coli | His | Pro41~Phe271 | |
| Human | ERAP2-3105H | Recombinant Human ERAP2 protein, His-tagged | E.coli | His | 41-180 aa | |
| Human | ERAP2-4356HF | Recombinant Full Length Human ERAP2 Protein, GST-tagged | In Vitro Cell Free System | GST | 350 amino acids |
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| Human | ERAP2-2881H | Recombinant Human ERAP2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | ERAP2-2881H-B | Recombinant Human ERAP2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | ERAP2-6628Z | Recombinant Zebrafish ERAP2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ERAP2 Related Articles
- ERAP2 Related Research Area
ERAP2 involved in several pathways and played different roles in them. We selected most pathways ERAP2 participated on our site, such as Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | CDKN1B;PAG1;RAPGEF3;DYNC1LI2;TRAT1;CD300E;AHCYL1;MGC174155;GAN |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | B2ML;ERAP1;ERAP2;SEC23A;SEC24A |
| Class I MHC mediated antigen processing & | RNF19B;ATG7;VPRBP;RNF220;RNF41;DZIP3;UBR2;ARIH2;RBCK1 |
| presentation | ASB4;FBXO17;PJA1;RNF220;CTSL2;TRIM50;RBCK1;TRAF7;PJA2 |
| Immune System | CD300E;DEFA5;DEFA1;IFIT10;OSCAR;CR1;TRIM31;DDX41;KPNA4 |
ERAP2 has several biochemical functions, for example, aminopeptidase activity, metalloaminopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERAP2 itself. We selected most functions ERAP2 had, and list some proteins which have the same functions with ERAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminopeptidase activity | XPNPEP3;METAP2;TPP2;XPNPEP1;METAP1;LTA4H;ERAP1;METAP2A;LAP3 |
| metalloaminopeptidase activity | RNPEPL1;ERAP2;RNPEP;ERAP1;LTA4H;METAP2B;METAP2A;LNPEP;ANPEPA |
| metallopeptidase activity | MMP23B;ADAMTS12;MEP1A.1;NPSN;AGBL1;BMP1;GM5136;ADAM10;ADAM18 |
| peptide binding | GPR22;ANG;GNRHR1;NPFFR1;RPS6KB2;HCRTR2;AVPR1B;NPFFR1L2;GPR37L1 |
| zinc ion binding | USP51;NR4A1;TAF3;RNF181;TRIM24;NR2C1;RNF139;BFAR;MECR |
ERAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERAP2.
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- Q&As
- Reviews
Q&As (7)
Ask a questionERAP2 is involved in blood pressure regulation, impacting hypertension development.
Genetic variations in ERAP2 affect susceptibility to infectious diseases, influencing immune system efficacy.
ERAP2 modulates the immune system, impacting the development and progression of autoimmune diseases.
Changes in ERAP2 can influence tumor immunity and cancer immune surveillance, impacting cancer progression and response to therapy.
ERAP2 modulates the stability and function of angiotensin II, affecting blood pressure and vascular homeostasis.
ERAP2 plays a role in inflammatory processes, potentially contributing to the pathology of various inflammatory disorders.
ERAP2 trims peptides for MHC class I presentation, crucial for immune recognition and response.
Customer Reviews (3)
Write a reviewAccurate protein structural analysis, a cornerstone of our investigations.
Timely protein expression optimization, improves our research efficiency.
Reliable antibody validation, essential for our immunoprecipitation studies.
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