erap2
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  • Official Full Name
  • endoplasmic reticulum aminopeptidase 2
  • Background
  • Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003
  • Synonyms
  • ERAP2; endoplasmic reticulum aminopeptidase 2; L RAP; leukocyte derived arginine aminopeptidase; LRAP; leukocyte-derived arginine aminopeptidase; L-RAP
Cat.#:ERAP2-3439HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERAP2 Protein, GST-tagged
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Cat.#:ERAP2-483HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERAP2 Protein, His-tagged
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Cat.#:ERAP2-304HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERAP2, His tagged
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Cat.#:ERAP2-936HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ERAP2
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Cat.#:ERAP2-6628ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ERAP2
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Cat.#:ERAP2-2777HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERAP2 cell lysate
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Involved Pathway

ERAP2 involved in several pathways and played different roles in them. We selected most pathways ERAP2 participated on our site, such as Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
FBXO17; RNF111; SH3RF1; SIGLEC10; CSK; ITGB1B.1; ERAP2; PIK3AP1; SIGLEC6; CTSC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
B2ML; ERAP1; ERAP2; SEC24A; SEC23A
Class I MHC mediated antigen processing &
ATG7; UBE2L6; RNF220; UBA5; LRR1; TPP2; ASB2; CYBB; ASB6; ASB17
presentation
RNF14; UFL1; UBE2L6; UBE2E3; CTSL2; LRSAM1; LRRC41; VPRBP; FBXO17; FBXO44
Immune System
TRIM2; TRIM68; DYNC1H1; TRIM45; LRRFIP1; IFIT12; ASB10; CFHL4; TXN; AP1B1

Protein Function

ERAP2 has several biochemical functions, for example, aminopeptidase activity, metalloaminopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERAP2 itself. We selected most functions ERAP2 had, and list some proteins which have the same functions with ERAP2. You can find most of the proteins on our site.
Function
Related Protein
Function aminopeptidase activity
Related Protein DPP9; TPP2; ERAP2; METAP1; ERAP1; NPEPPS; Ctsl; Npepo; TRHDE; DNPEP
Function metalloaminopeptidase activity
Related Protein METAP2B; RNPEPL1; ERAP1; METAP2A; ANPEP; ERAP2; TRHDE; ANPEPA; LNPEP; Npepo
Function metallopeptidase activity
Related Protein C6AST3; ADAM17; Adamts19; ANPEPA; PAPLNB; TAF2; CNDP1; PAPPA; NPSN; YME1L1
Function peptide binding
Related Protein BDKRB1; ENPEP; LTA4H; NPFFR1L1; ANPEPB; RNPEPL1; CTSL2; OXTRL; ANPEP; GNRHR4
Function zinc ion binding
Related Protein FHL1A; ZDHHC8B; NSMCE2; MAN2C1; MT1H; RPS29; ZZEF1; TRIM5; FNTB; MMP13A

Interacting Protein

ERAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERAP2.
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ERAP2 Related Articles

Hulur, I; Gamazon, ER; et al. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC GENOMICS 16:-(2015).
Papkyriakou, A; Zervoudi, E; et al. 3,4-Diaminobenzoic Acid Derivatives as Inhibitors of the Oxytocinase Subfamily of M1 Aminopeptidases with Immune-Regulating Properties. JOURNAL OF MEDICINAL CHEMISTRY 58:1524-1543(2015).