efna2
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  • Official Full Name
  • ephrin-A2
  • Background
  • This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.
  • Synonyms
  • EFNA2; ephrin-A2; EPLG6; ELF 1; LERK6; EFNA 2; EFNA2_HUMAN; ELF1; Eph related receptor tyrosine kinase ligand 6; EPH-related receptor tyrosine kinase ligand 6; EphrinA2; HEK7 L; HEK7 ligand; HEK7-L; HEK7L; LERK-6; Ligand of eph related kinase 6; ELF-1
Cat.#:Efna2-361RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Efna2 Protein, Fc-tagged
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Cat.#:EFNA2-1381HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA2 Protein, MYC/DDK-tagged
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Cat.#:EFNA2-3098HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EFNA2 Protein, GST-tagged
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Cat.#:Efna2-431MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ephrin A2, His-tagged
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Cat.#:EFNA2-28624THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EFNA2
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Cat.#:EFNA2-978HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human EFNA2 Protein, Fc Chimera
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Cat.#:Efna2-1731MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ephrin A2
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Cat.#:Efna2-4047MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efna2, His tagged
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Cat.#:Efna2-4048MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efna2, None tagged
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Cat.#:EFNA2-6541CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EFNA2
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Cat.#:EFNA2-2004MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EFNA2 cell lysate
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Involved Pathway

Efna2 involved in several pathways and played different roles in them. We selected most pathways Efna2 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
EPHB4A; GNAI1; FRS2A; EFNB2A; SEMA3B; SEMA3AA; ARPC3; EPHA5; KALRN; CDK5R1B
Developmental Biology
EPHA4A; CAP2; ITGB1B.1; SIAH2; ARPC1A; PEA15A; MED29; DUSP1; SPTBN2; FRS3
EPH-Ephrin signaling
MYL12A; EFNA1B; ARHGEF28; AP2M1; EPHA2; EFNA3B; EPHA4A; ARPC3; EFNB1; MYL9
EPH-ephrin mediated repulsion of cells
EFNA5; EPHA2A; EFNB3; EFNA1B; EFNB2A; EFNA1A; EFNB2; CLTB; EFNA2; EFNB3B
EPHA forward signaling
BLK; EFNA2; EFNA5; EFNA1; EFNA3; EPHA2; ARHGEF15; CRKL
EPHA-mediated growth cone collapse
EFNA4; EFNA1B; EFNA5; EPHA10; EFNA2; EPHA2A; EFNA1; EFNA3; EPHA2; EPHA4A
PI3K-Akt signaling pathway
PIK3AP1; CSF1R; LAMC3; CSF3R; CSF1; COMP; CSF3; EFNA4; CSH1; CSH
Rap1 signaling pathway
LOC608458; CSF1; EFNA2; EFNA4; RGS14; PFN4

Protein Function

Efna2 has several biochemical functions, for example, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna2 itself. We selected most functions Efna2 had, and list some proteins which have the same functions with Efna2. You can find most of the proteins on our site.
Function
Related Protein
Function ephrin receptor binding
Related Protein PIK3CG; CDK5; CBL; NTRK3; CHN1; CRK; PTPN1; SIPA1L1; GRB2; EFNB3

Interacting Protein

Efna2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna2.
Chn2; Epha1

Efna2 Related Articles

Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).
Pentheroudakis, G; Kotoula, V; et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC CANCER 13:-(2013).