efnb2
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  • Official Full Name
  • Ephrin-B2
  • Background
  • Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
  • Synonyms
  • EPHB2; EPH receptor B2; DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; MGC87492; ephrin type-B receptor 2; EPH-like kinase 5; eph tyrosine kinase 3; elk-related tyrosine kinase; protein-tyrosine kinase HEK5; tyrosine-protein kinase TYRO5; renal carcinoma antigen NY-REN-47; tyrosine-protein kinase receptor EPH-3; developmentally-regulated Eph-related tyrosine kinase; EphB2; EC=2.7.10.1; Developmentally-regulated Eph-related tyrosine kinase; CAPB; PCBC; EFN B2; EFNB 2; EFNB2; Eph related receptor tyrosine kinase ligand 5; EPH-related receptor tyrosine kinase ligand 5; Ephrin-B2; EphrinB2; EPLG 5; EPLG5; Htk L; HTK ligand; HTK-L; HTKL; LERK 5; LERK-5; LERK5; Ligand of eph related kinase 5 antibody; MGC126226; MGC126227; MGC126228; OTTMUSP00000024973; Htk-L; ELF-2; NLERK-1
Cat.#:EFNB2-2032HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNB2 Protein, His-tagged
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Cat.#:EFNB2-1378HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNB2 Protein, MYC/DDK-tagged
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Cat.#:EFNB2-3104HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EFNB2 Protein, GST-tagged
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Cat.#:Efnb2-1377MTag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efnb2 Protein, Fc/His-tagged
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Cat.#:Efnb2-1734MTag:Fc|His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ephrin B2, Fc-His
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Cat.#:EFNB2-1134HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EFNB2 protein, His & GST-tagged
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Cat.#:EFNB2-2240HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNB2, Fc-His tagged
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Cat.#:EFNB2-272HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNB2, ENLYFQ tagged
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Cat.#:EFNB2-3191HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNB2, His tagged
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Cat.#:EFNB2-358HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNB2 Protein
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Cat.#:EFNB2-480HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EFNB2
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Cat.#:EFNB2-6870HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ephrin-B2, His-tagged
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Cat.#:Efnb2-198MTag:Fc Chimera
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Efnb2, Fc Chimera
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Cat.#:Efnb2-199MTag:Fc Chimera
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Efnb2, Fc Chimera, Biotinylated
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Cat.#:Efnb2-3315MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efnb2, His tagged
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Cat.#:Efnb2-367MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Efnb2 Protein, His-tagged
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Cat.#:EFNB2-882MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EFNB2 Protein, Fc-tagged
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Cat.#:EFNB2-1078RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat EFNB2 Protein, Fc-tagged
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Cat.#:Efnb2-7435RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Efnb2, His tagged
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Cat.#:EFNB2-175CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine EFNB2, Fc tagged
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Cat.#:EFNB2-297CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine EFNB2, His tagged
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Cat.#:EFNB2-6387CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EFNB2
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Cat.#:EFNB2-5264HTag:His
Source (Host):HEK293ESpecies:Human
Product nameRecombinant Human Ephrin-B2, His-tagged
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Cat.#:EFNB2-936HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNB2 cell lysate
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Cat.#:EFNB2-2405MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EFNB2 cell lysate
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Cat.#:EFNB2-1540RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat EFNB2 cell lysate
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Cat.#:EFNB2-965CCLTag:N/A
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine EFNB2 cell lysate
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Involved Pathway

Efnb2 involved in several pathways and played different roles in them. We selected most pathways Efnb2 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efnb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
FRS2; AGRN; DUSP1; GPC1B; SCN2A; DUSP9; COL6A2; CDC42; DNM1; TRPC4
Developmental Biology
EFNB1; MED22; DPYSL3; CDK8; SPTA1; NR2F2; AP2A2; PLXND1; JAK1; PAQR3A
EPH-Ephrin signaling
EFNA4; ARPC2; ARPC3; EFNA1; ARPC1A; EFNB1; EPHA2; ACTR2; ACTR3; MYL9
EPH-ephrin mediated repulsion of cells
EFNA1B; EFNA4; EPHB4B; EFNA2A; EFNA1A; EFNB3B; EPHA10; AP2A2; EFNA5; EFNB2
EPHB forward signaling
EFNB3; GRB7; EFNA5; ITSN1; EFNB1; EFNB2
EPHB-mediated forward signaling
ITSN1; ARPC4; EFNB2A; ARPC5; ACTR3; EFNB3B; KALRN; EFNB2; EPHB3A; EPHB4A
Ephrin B reverse signaling
EFNB1; EFNB2; PTPN13
Ephrin signaling
EFNB2A; MYL12A; EPHB4B; EFNB3; EPHB3A; SDCBP; EFNB2; EFNB3B; EPHB4A; EFNB1

Protein Function

Efnb2 has several biochemical functions, for example, ephrin receptor binding, protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Efnb2 itself. We selected most functions Efnb2 had, and list some proteins which have the same functions with Efnb2. You can find most of the proteins on our site.
Function
Related Protein
Function ephrin receptor binding
Related Protein SIPA1L1; EFNA4; EFNA2; CRK; PIK3CG; EFNA5B; EFNA1A; EFNB1; EFNA1B; SDCBP
Function protein binding
Related Protein ABCG1; SMARCA5; LZTFL1; ORAI1; ZNF133; ZNF404; CENPK; SNRPB2; DDX31; C2orf50
Function virus receptor activity
Related Protein ITGB7; CD209; SELPLG; AXL; ITGAV; HSPA1A; SLC20A2; CLEC4G; CR2; CLEC5A

Interacting Protein

Efnb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efnb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efnb2.
NCK2