fasn
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  • Official Full Name
  • fatty acid synthase
  • Background
  • Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN geneFatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.
  • Synonyms
  • FASN; fatty acid synthase; FAS; SDR27X1; short chain dehydrogenase/reductase family 27X; member 1; short chain dehydrogenase/reductase family 27X, member 1; OA-519; MGC14367; MGC15706
Cat.#:FASN-718HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASN Protein, His/GST-tagged
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Cat.#:Fasn-719MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fasn Protein, His-tagged
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Cat.#:Fasn-720RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fasn Protein, His-tagged
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Cat.#:FASN-717CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken FASN Protein, His-tagged
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Cat.#:FASN-138HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASN protein, MYC/DDK-tagged
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Cat.#:FASN-20HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FASN, GST-tagged
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Cat.#:FASN-21HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FASN, GST-tagged
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Cat.#:FASN-28809THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASN, His-tagged
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Cat.#:FASN-468HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FASN
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Cat.#:FASN-5686MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FASN Protein
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Cat.#:Fasn-596MTag:His|Myc
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fasn protein, His/Myc-tagged
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Cat.#:Fasn-59MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fasn protein, His-tagged
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Cat.#:FASN-2275RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FASN Protein
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Cat.#:FASN-6712CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FASN
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Cat.#:FASN-597HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FASN cell lysate
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Involved Pathway

FASN involved in several pathways and played different roles in them. We selected most pathways FASN participated on our site, such as Fatty acid biosynthesis, Metabolic pathways, Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FASN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fatty acid biosynthesis
ACSL1; ACSL3; ACSBG1; ACSL4B; FASN; ACAA2; ECH1; OLAH; ACSL3A; ACSBG2
Metabolic pathways
GPT2L; QDPRA; AMY2A3; IDH3A; NOS3; ATP6V1H; WBSCR17; CKMT2B; DHDPSL; B4GALNT1
Fatty acid metabolism
PTPLAD2; ACSL4B; ELOVL5; CPT1A; HADHAA; HSD17B12B; Scd2; TECRB; HSD17B12A; ELOVL2
AMPK signaling pathway
LIPE; HMGCR; PRKAG1; PPP2R1A; ADIPOR2; FOXO3; PFKP; SLC2A4; AKT3; PPP2CB
Insulin signaling pathway
PPP1CAA; PIK3CB; PIK3R3A; PHKA2; MTOR; SREBF1; PRKAG3; ACACA; TRIP10A; RHEB

Protein Function

FASN has several biochemical functions, for example, 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity, 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FASN itself. We selected most functions FASN had, and list some proteins which have the same functions with FASN. You can find most of the proteins on our site.
Function
Related Protein
Function 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Related Protein FASN
Function 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
Related Protein FASN
Function 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Related Protein FASN
Function 3-oxoacyl-[acyl-carrier-protein] synthase activity
Related Protein OXSM; FASN
Function NADPH binding
Related Protein CRYZ; QDPR; CBR3; HMGCR; MTRR; TP53I3; KCNAB1; DHFR; FASN; CBR4
Function [acyl-carrier-protein] S-acetyltransferase activity
Related Protein FASN
Function [acyl-carrier-protein] S-malonyltransferase activity
Related Protein FASN; MCAT
Function drug binding
Related Protein FOLR1; MT3; SLC6A4A; HMGCS1; PDXK; SRP54; PPP3CA; GRIK1; GPR30; NAMPT
Function enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
Related Protein FASN
Function enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
Related Protein FASN
Function fatty acid synthase activity
Related Protein FASN
Function myristoyl-[acyl-carrier-protein] hydrolase activity
Related Protein FASN; OLAH
Function oleoyl-[acyl-carrier-protein] hydrolase activity
Related Protein FASN; OLAH
Function palmitoyl-[acyl-carrier-protein] hydrolase activity
Related Protein OLAH; FASN
Function poly(A) RNA binding
Related Protein EIF4G3; PCBP4; FDPS; IPO5; EIF3H; SAFB2; DDX5; MECP2; ZFP326; NSUN2
Function protein binding
Related Protein SNX9; C8orf33; RHNO1; HHIPL2; SS18; SH2D4A; EIF2A; POU3F3; MAP2K6; DHX9
Function protein homodimerization activity
Related Protein HNF1B; LHPP; STC2; CD226; IL6ST; PRKG2; TYRP1; IRAK1; CHMP1A; MIXL1

Interacting Protein

FASN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASN here. Most of them are supplied by our site. Hope this information will be useful for your research of FASN.
q99ib8-pro_0000045603; ILK; YWHAZ; NFKB2; MAP3K1; Bles03; NDRG1; MAP3K3; IKBKG; p29991-pro_0000308465; AKT1; EWSR1; PRR12; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

FASN Related Articles

Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).
Zaytseva, YY; Elliott, VA; et al. Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. CARCINOGENESIS 35:1341-1351(2014).