| Description : |
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
273.2 kDa |
| AA Sequence : |
MEEVVIAGMSGKLPESENLQEFWDN LIGGVDMVTDDDRRWKAGLYGLPRR SGKLKDLSRFDASFFGVHPKQAHTM DPQLRLLLEVTYEAIVDGGINPDSL RGTHTGVWVGVSGSETSEALSRDPE TLVGYSMVGCQRAMMANRLSFFFDF RGPSIALDTACSSSLMALQNAYQAI HSGQCPAAIVGGINVLLKPNTSVQF LRLGMLSPEGTCKAFDTAGNGYCRS EGVVAVLLTKKSLARRVYATILNAG TNTDGFKEQGVTFPSGDIQEQLIRS LYQSAGVAPESFEYIEAHGTGTKVG DPQELNGITRALCATRQEPLLIGST KSNMGHPEPASGLAALAKVLLSLEH GLWAPNLHFHSPNPEIPALLDGRLQ VVDQPLPVRGGNVGINSFGFGGSNV HIILRPNTQPPPAPAPHATLPRLLR ASGRTPEAVQKLLEQGLRHSQDLAF LSMLNDIAAVPATAMPFRGYAVLGG ERGGPEVQQVPAGERPLWFICSGMG TQWRGMGLSLMRLDRFRDSILRSDE AVKPFGLKVSQLLLSTDESTFDDIV HSFVSLTAIQIGLIDLLSCMGLRPD GIVGHSLGEVACGYADGCLSQEEAV LAAYWRGQCIKEAHLPPGAMAAVGL SWEECKQRCPPGVVPACHNSKDTVT ISGPQAPVFEFVEQLRKEGVFAKEV RTGGMAFHSYFMEAIAPPLLQELKK VIREPKPRSARWLSTSIPEAQWHSS LARTSSAEYNVNNLVSPVLFQEALW HVPEHAVVLEIAPHALLQAVLKRGL KPSCTIIPLMKKDHRDNLEFFLAGI GRLHLSGIDANPNALFPPVEFPAPR GTPLISPLIKWDHSLAWDVPAAEDF PNGSGSPSAAIYNIDTSSESPDHYL VDHTLDGRVLFPATGYLSIVWKTLA RALGLGVEQLPVVFEDVVLHQATIL PKTGTVSLEVRLLEASRAFEVSENG NLVVSGKVYQWDDPDPRLFDHPESP TPNPTEPLFLAQAEVYKELRLRGYD YGPHFQGILEASLEGDSGRLLWKDN WVSFMDTMLQMSILGSAKHGLYLPT RVTAIHIDPATHRQKLYTLQDKAQV ADVVVSRWLRVTVAGGVHISGLHTE SAPRRQQEQQVPILEKFCFTPHTEE GCLSERAALQEELQLCKGLVQALQT TVTQQGLKMVVPGLDGAQIPRDPSQ QELPRLLSAACRLQLNGNLQLELAQ VLAQERPKLPEDPLLSGLLDSPALK ACLDTAVENMPSLKMKVVEVLAGHG HLYSRIPGLLSPHPLLQLSYTATDR HPQALEAAQAELQQHDVAQGQWDPA DPAPSALGSADLLVCNCAVAALGDP ASALSNMVAALREGGFLLLHTLLRG HPLGDIVAFLTSTEPQYGQGILSQD AWESLFSRVSLRLVGLKKSFYGSTL FLCRRPTPQDSPIFLPVDDTSFRWV ESLKGILADEDSSRPVWLKAINCAT SGVVGLVNCLRREPGGNRLRCVLLS NLSSTSHVPEVDPGSAELQKVLQGD LVMNVYRDGAWGAFRHFLLEEDKPE EPTAHAFVSTLTRGDLSSIRWVCSS LRHAQPTCPGAQLCTVYYASLNFRD IMLATGKLSPDAIPGKWTSQDSLLG MEFSGRDASGKRVMGLVPAKGLATS VLLSPDFLWDVPSNWTLEEAASVPV VYSTAYYALVVRGRVRPGETLLIHS GSGGVGQAAIAIALSLGCRVFTTVG SAEKRAYLQARFPQLDSTSFANSRD TSFEQHVLWHTGGKGVDLVLNSLAE EKLQASVRCLATHGRFLEIGKFDLS QNHPLGMAIFLKNVTFHGVLLDAFF NESSADWREVWALVQAGIRDGVVRP LKCTVFHGAQVEDAFRYMAQGKHIG KVVVQVLAEEPEAVLKGAKPKLMSA ISKTFCPAHKSYIIAGGLGGFGLEL AQWLIQRGVQKLVLTSRSGIRTGYQ AKQVRRWRRQGVQVQVSTSNISSLE GARGLIAEAAQLGPVGGVFNLAVVL RDGLLENQTPEFFQDVCKPKYSGTL NLDRVTREACPELDYFVVFSSVSCG RGNAGQSNYGFANSAMERICEKRRH EGLPGLAVQWGAIGDVGILVETMST NDTIVSGTLPQRMASCLEVLDLFLN QPHMVLSSFVLAEKAAAYRDRDSQR DLVEAVAHILGIRDLAAVNLDSSLA DLGLDSLMSVEVRQTLERELNLVLS VREVRQLTLRKLQELSSKADEASEL ACPTPKEDGLAQQQTQLNLRSLLVN PEGPTLMRLNSVQSSERPLFLVHPI EGSTTVFHSLASRLSIPTYGLQCTR AAPLDSIHSLAAYYIDCIRQVQPEG PYRVAGYSYGACVAFEMCSQLQAQQ SPAPTHNSLFLFDGSPTYVLAYTQS YRAKLTPGCEAEAETEAICFFVQQF TDMEHNRVLEALLPLKGLEERVAAA VDLIIKSHQGLDRQELSFAARSFYY KLRAAEQYTPKAKYHGNVMLLRAKT GGAYGEDLGADYNLSQVCDGKVSVH VIEGDHRTLLEGSGLESIISIIHSS LAEPRVSVREGTRRLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
