|Official Full Name||fibrillin 1|
|Background||This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.|
|Synonyms||FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS; fibrillin 15; FBN; WMS; MFS1; SSKS; WMS2; ACMICD; GPHYSD2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
FBN1 involved in several pathways and played different roles in them. We selected most pathways FBN1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Elastic fibre formation||ITGB3A; MFAP3; MFAP4; LOXL3; BMP10; FBLN2; EFEMP2; LOX; LOXL2; EFEMP1|
|Extracellular matrix organization||TLL1; DAG1; COL9A1A; COL28A1A; MUSK; LEPRE1; MMP15; TIMP2; LOXL2; LRP4|
|Integrin cell surface interactions||COL16A1; COL9A1B; COL23A1; F11R.2; COMP; FBN1; BSG; JAM2B; FN1B; COL13A1|
FBN1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by FBN1 itself. We selected most functions FBN1 had, and list some proteins which have the same functions with FBN1. You can find most of the proteins on our site.
|calcium ion binding||NID2; GAS6; SYT11A; PCDH1A6; NELL1; LDLRB; S100A8; ALOX8; SPOCK3; TPO|
|extracellular matrix constituent conferring elasticity||FBN2; FBN1|
|extracellular matrix structural constituent||COL11A1B; COL5A1; COL1A2; IMPG2; COL11A1A; COL27A1; COL4A4; ACAN; ELNA; COL4A6|
|integrin binding||TNN; DMP1; ADAM2; ADAM9; EMP2; ICAM3; ADAM22; ECM2; SEMA7A; FBLN1|
|protein binding||DCP1A; FTH1; PRMT2; PINK1; GLYCTK; MT3; WDR61; HTRA3; RQCD1; SEPT9|
|protein complex binding||DRD1A; NCK2; STRN; RBM10; CRHR1; ATM; ING2; TULP3; PLK2; NOG|
FBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBN1.
EFEMP2; LOX; ELN; MFAP4; FN1; FBN2; LTBP1; LTBP4; FBLN5