FBN1
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Official Full Name
fibrillin 1
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Overview
This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome. -
Synonyms
FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS; fibrillin 15; FBN; WMS; MFS1; SSKS; WMS2; ACMICD; GPHYSD2;
- Recombinant Proteins
- Human
- Mouse
- Rat
- CHO
- E. coli
- E.coli
- HEK293T
- Mammalian cells
- NS0
- Wheat Germ
- C
- His
- Myc
- DDK
- Fc
- GST
- His|GST
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | FBN1-284H | Recombinant Human FBN1 protein, His-tagged | E.coli | His | Val449~Cys711 | |
| Human | FBN1-28892TH | Recombinant Human FBN1 | Wheat Germ | N/A | 100 amino acids |
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| Human | FBN1-3878H | Recombinant Human FBN1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | FBN1-281H | Recombinant Human FBN1 protein, His-tagged | E.coli | His | Ile81~Ile236 | |
| Human | FBN1-285H | Recombinant Human FBN1 protein, His-tagged | E.coli | His | Gly2727~Pro2835 | |
| Human | FBN1-2622H | Recombinant Human FBN1 protein, His & GST-tagged | E.coli | His/GST | Asp246~Cys389 (Accession # P35555) |
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| Human | FBN1-282H | Recombinant Human FBN1 protein, His-tagged | E.coli | His | Asp246~Cys389 | |
| Human | FBN1-283H | Recombinant Human FBN1 protein, His-tagged | E.coli | His | Asp723~Arg902 | |
| Human | FBN1-2621H | Recombinant Human FBN1 protein, His & GST-tagged | E.coli | His/GST | Ile81~Ile236 (Accession # P35555) |
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| Human | FBN1-2624H | Recombinant Human FBN1 protein, His & GST-tagged | E.coli | His/GST | Asp723~Arg902 (Accession # P35555) |
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| Human | FBN1-2623H | Recombinant Human FBN1 protein, His & GST-tagged | E.coli | His/GST | Val449~Cys711 (Accession # P35555) |
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| Human | FBN1-1883H | Recombinant Human FBN1 protein, GST-tagged | E.coli | GST | 783-850 aa | |
| Human | FBN1-01H | Active Recombinant Human FBN1 Protein, Fc-tagged | CHO | Fc |
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| Human | FBN1-01HCL | Recombinant Human FBN1 Over-expression Lysate, C-Myc/DDK tagged | HEK293T | C-Myc/DDK |
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| Human | FBN1-02H | Active Recombinant Human FBN1 Protein, Fc-tagged | NS0 | Fc |
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| Human | FBN1-2737H | Recombinant Human FBN1 protein(2701-2870 aa), C-His-tagged | E. coli | C-His | 2701-2870 aa |
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| Human | FBN1-371H | Recombinant Human FBN1 Protein, His-tagged | E.coli | N-His | Ser2732-His2871 |
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| Human | FBN1-2314H | Recombinant Human FBN1 Protein (Ser2732-His2871), C-His tagged | Mammalian cells | C-His | Ser2732-His2871 |
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| Human | FBN1-0613H | Recombinant Human FBN1 Protein (Ser2732-His2871), N-His-tagged | E.coli | N-His | Ser2732-His2871 |
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| Human | FBN1-2315H | Recombinant Human FBN1 Protein (Asn783-Lys850), N-His tagged | E.coli | N-His | Asn783-Lys850 |
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| Mouse | Fbn1-2627M | Recombinant Mouse Fbn1 protein, His-tagged | E.coli | His | Ala1703~Thr1889 |
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| Mouse | Fbn1-2625M | Recombinant Mouse Fbn1 protein, His-tagged | E.coli | His | Leu455~Asp632 |
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| Mouse | Fbn1-2626M | Recombinant Mouse Fbn1 protein, His-tagged | E.coli | His | Thr959~Gly1145 |
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| Mouse | Fbn1-1465M | Recombinant Mouse Fbn1 Protein, His-tagged | E.coli | N-His | Leu457-Asp634 |
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| Rat | Fbn1-2628R | Recombinant Rat Fbn1 protein, His-tagged | E.coli | His | Cys751~Pro895 (Accession # Q9WUH8) |
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| Rat | Fbn1-2629R | Recombinant Rat Fbn1 protein, His-tagged | E.coli | His | Ile1475~Tyr1638 (Accession # Q9WUH8) |
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| Rat | Fbn1-2630R | Recombinant Rat Fbn1 protein, His-tagged | E.coli | His | Cys168~Arg364 (Accession # Q9WUH8) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- FBN1 Related Articles
FBN1 involved in several pathways and played different roles in them. We selected most pathways FBN1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Integrin cell surface interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Elastic fibre formation | MFAP2;LOXL3;ITGB3A;ABHD1;FURINA;FURINB;LOXL1;LOXL4;LOX |
| Extracellular matrix organization | CTSD;TLDC2;PCOLCE2;COL8A1;BGNB;LEPREL2;DMD;LOXL3;MMP8 |
| Integrin cell surface interactions | JAM2B;COL9A1A;FBN1;LOC100514666;ICAM4;COL23A1;COL9A1B;BSG;COL16A1 |
FBN1 has several biochemical functions, for example, calcium ion binding, extracellular matrix constituent conferring elasticity, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by FBN1 itself. We selected most functions FBN1 had, and list some proteins which have the same functions with FBN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | SLC24A1;ANXA1A;PROCA;CDH19;OVAL;PCDHGB4;MYL1;MCFD2;AIF1L |
| extracellular matrix constituent conferring elasticity | FBN1;FBN2 |
| extracellular matrix structural constituent | COL1A1B;LAMC1;OPTC;FBN1;COL11A1A;COL4A4;COL11A1B;CHI3L1;COL1A1A |
| integrin binding | COL3A1;Npnt;ADAM17;AMICA1;SFRP2;CIB2;WISP1B;CD9;ESM1 |
| protein binding | GRB2;ZNF576;VDR;UCHL5;CALCR;SNRPE;AGTRAP;MAB21L3;PCNP |
| protein complex binding | NOG;NRAS;RXRA;SHARPIN;PDCL;SLC27A5;CEBPA;YWHAB;VPS28 |
FBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBN1.
EFEMP2; LOX; ELN; MFAP4; FN1; FBN2; LTBP1; LTBP4; FBLN5
- Q&As
- Reviews
Q&As (7)
Ask a questionTargeting FBN1 offers potential for treating connective tissue disorders by restoring matrix integrity and function.
Genetic mutations in FBN1 can lead to various connective tissue disorders, affecting tissue strength and flexibility.
Altered FBN1 activity is associated with cardiovascular conditions due to its role in maintaining blood vessel structure.
FBN1 plays a critical role in the development of connective tissues, including tendons, ligaments, and blood vessels.
FBN1, or Fibrillin-1, is essential for the formation of the extracellular matrix, providing structural support to tissues.
FBN1 interacts with other extracellular matrix proteins, such as elastin, in building and maintaining tissue architecture.
It contributes to tissue elasticity and integrity by forming microfibrils that reinforce the matrix.
Customer Reviews (3)
Write a reviewExcellent in cell culture functionality
Exceptional specificity in immunohistochemistry
Highly stable and reliable in assays
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