fbn1
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  • Official Full Name
  • fibrillin 1
  • Background
  • This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.
  • Synonyms
  • FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS; fibrillin 15; FBN; WMS; MFS1; SSKS; WMS2; ACMICD; GPHYSD2
Cat.#:FBN1-3878HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBN1 Protein, GST-tagged
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Cat.#:FBN1-2621HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His & GST-tagged
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Cat.#:FBN1-2622HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His & GST-tagged
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Cat.#:FBN1-2623HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His & GST-tagged
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Cat.#:FBN1-2624HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His & GST-tagged
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Cat.#:FBN1-281HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His-tagged
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Cat.#:FBN1-282HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His-tagged
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Cat.#:FBN1-283HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His-tagged
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Cat.#:FBN1-284HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His-tagged
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Cat.#:FBN1-285HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBN1 protein, His-tagged
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Cat.#:FBN1-28892THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FBN1
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Cat.#:Fbn1-2625MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fbn1 protein, His-tagged
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Cat.#:Fbn1-2626MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fbn1 protein, His-tagged
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Cat.#:Fbn1-2627MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fbn1 protein, His-tagged
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Cat.#:Fbn1-2628RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbn1 protein, His-tagged
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Cat.#:Fbn1-2629RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbn1 protein, His-tagged
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Cat.#:Fbn1-2630RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbn1 protein, His-tagged
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Involved Pathway

FBN1 involved in several pathways and played different roles in them. We selected most pathways FBN1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Integrin cell surface interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBN1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Elastic fibre formation
FBN2; BMP10; LOXL2; LOX; ABHD1; FBLN1; MFAP4; MFAP5; FURINA; ITGB3A
Extracellular matrix organization
MFAP4; PCOLCE2; LOC100514666; FBN1; KLK7; DDR2; TIMP2; MMP10; COL4A4; BMP10
Integrin cell surface interactions
COL9A1B; F11R.2; FN1B; COL9A1A; ICAM4; COL23A1; COL16A1; FBN1; COL13A1; JAM2B

Protein Function

FBN1 has several biochemical functions, for example, calcium ion binding, extracellular matrix constituent conferring elasticity, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by FBN1 itself. We selected most functions FBN1 had, and list some proteins which have the same functions with FBN1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CABP5B; PSPH; TTYH1; MYL9B; CAPN9; MMP14B; DAG1; C1S; GSN; EHD1A
Function extracellular matrix constituent conferring elasticity
Related Protein FBN2; FBN1
Function extracellular matrix structural constituent
Related Protein LAMA1; COL1A1B; EFEMP2; CHI3L1; MFAP5; ELNA; FBN1; COL11A2; PRELP; COL1A1
Function integrin binding
Related Protein CYR61L1; ADAM2; CYR61; LYN; ACTN3; LAMB1; NOV; COL3A1; ADAM22; NISCH
Function protein binding
Related Protein TMED2; ATP6V1C1; Rhox5; GNAQ; TMEM132D; RBM3; DDX18; TRMT112; GAS2L3; STX2
Function protein complex binding
Related Protein RIPK3; CTSL2; ING2; LAMB3; MTAP1B; MYC; MLKL; PAFAH1B1; CPS1; COG2

Interacting Protein

FBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBN1.
EFEMP2; LOX; ELN; MFAP4; FN1; FBN2; LTBP1; LTBP4; FBLN5

FBN1 Related Articles

Perez-Rico, C; Pascual, G; et al. Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:6309-6318(2014).
Beene, LC; Wang, LW; et al. Nonselective Assembly of Fibrillin 1 and Fibrillin 2 in the Rodent Ocular Zonule and in Cultured Cells: Implications for Marfan Syndrome. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:8337-8344(2013).