FBN1

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FBN1

Official Full Name fibrillin 1
Background This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.
Synonyms FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS; fibrillin 15; FBN; WMS; MFS1; SSKS; WMS2; ACMICD; GPHYSD2
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FBN1-2621H Recombinant Human FBN1 protein, His & GST-tagged E.coli His/GST
    Human FBN1-2622H Recombinant Human FBN1 protein, His & GST-tagged E.coli His/GST
    Human FBN1-2623H Recombinant Human FBN1 protein, His & GST-tagged E.coli His/GST
    Human FBN1-2624H Recombinant Human FBN1 protein, His & GST-tagged E.coli His/GST
    Human FBN1-281H Recombinant Human FBN1 protein, His-tagged E.coli His
    Human FBN1-282H Recombinant Human FBN1 protein, His-tagged E.coli His
    Human FBN1-283H Recombinant Human FBN1 protein, His-tagged E.coli His
    Human FBN1-284H Recombinant Human FBN1 protein, His-tagged E.coli His
    Human FBN1-285H Recombinant Human FBN1 protein, His-tagged E.coli His
    Human FBN1-28892TH Recombinant Human FBN1 Wheat Germ N/A
    Human FBN1-3878H Recombinant Human FBN1 Protein, GST-tagged Wheat Germ GST
    Mouse Fbn1-2625M Recombinant Mouse Fbn1 protein, His-tagged E.coli His
    Mouse Fbn1-2626M Recombinant Mouse Fbn1 protein, His-tagged E.coli His
    Mouse Fbn1-2627M Recombinant Mouse Fbn1 protein, His-tagged E.coli His
    Rat Fbn1-2628R Recombinant Rat Fbn1 protein, His-tagged E.coli His
    Rat Fbn1-2629R Recombinant Rat Fbn1 protein, His-tagged E.coli His
    Rat Fbn1-2630R Recombinant Rat Fbn1 protein, His-tagged E.coli His

    FBN1 involved in several pathways and played different roles in them. We selected most pathways FBN1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Elastic fibre formation ITGB3A; MFAP3; MFAP4; LOXL3; BMP10; FBLN2; EFEMP2; LOX; LOXL2; EFEMP1
    Extracellular matrix organization TLL1; DAG1; COL9A1A; COL28A1A; MUSK; LEPRE1; MMP15; TIMP2; LOXL2; LRP4
    Integrin cell surface interactions COL16A1; COL9A1B; COL23A1; F11R.2; COMP; FBN1; BSG; JAM2B; FN1B; COL13A1

    FBN1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by FBN1 itself. We selected most functions FBN1 had, and list some proteins which have the same functions with FBN1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding NID2; GAS6; SYT11A; PCDH1A6; NELL1; LDLRB; S100A8; ALOX8; SPOCK3; TPO
    extracellular matrix constituent conferring elasticity FBN2; FBN1
    extracellular matrix structural constituent COL11A1B; COL5A1; COL1A2; IMPG2; COL11A1A; COL27A1; COL4A4; ACAN; ELNA; COL4A6
    integrin binding TNN; DMP1; ADAM2; ADAM9; EMP2; ICAM3; ADAM22; ECM2; SEMA7A; FBLN1
    protein binding DCP1A; FTH1; PRMT2; PINK1; GLYCTK; MT3; WDR61; HTRA3; RQCD1; SEPT9
    protein complex binding DRD1A; NCK2; STRN; RBM10; CRHR1; ATM; ING2; TULP3; PLK2; NOG

    FBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBN1.

    EFEMP2; LOX; ELN; MFAP4; FN1; FBN2; LTBP1; LTBP4; FBLN5

    Perez-Rico, C; Pascual, G; et al. Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:6309-6318(2014).
    Beene, LC; Wang, LW; et al. Nonselective Assembly of Fibrillin 1 and Fibrillin 2 in the Rodent Ocular Zonule and in Cultured Cells: Implications for Marfan Syndrome. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:8337-8344(2013).

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