"FBN1" Related Products

Recombinant Human FBN1 protein, His-tagged

Cat.No.: FBN1-282H
Product Overview: Recombinant Human FBN1(Asp246~Cys389) fused with His tag at N-terminal was expressed in E. coli.
Description: This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome.
Source: E. coli
Species: Human
Tag: His
Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass: 47.2kDa
Protein length: Asp246~Cys389
Endotoxin: <1.0EU per 1µg (determined by the LAL method)
Purity: > 95%
Applications: SDS-PAGE; WB; ELISA; IP.
Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigradefor 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigradefor one month. Aliquot and store at -80 centigradefor 12 months.
Reconstitution: Reconstitute in PBS or others.
Gene Name: FBN1 fibrillin 1 [ Homo sapiens ]
Official Symbol: FBN1
Synonyms: FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS; fibrillin 15; FBN; WMS; MFS1; SSKS; WMS2; ACMICD; GPHYSD2;
Gene ID: 2200
mRNA Refseq: NM_000138
Protein Refseq: NP_000129
MIM: 134797
UniProt ID: P35555
Chromosome Location: 15q21.1
Pathway: Integrin cell surface interactions, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function: calcium ion binding; extracellular matrix structural constituent; protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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