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Recombinant Human FBN1 protein, His-tagged

Cat.No. : FBN1-285H
Product Overview : Recombinant Human FBN1(Gly2727~Pro2835) fused with His tag at N-terminal was expressed in E. coli.
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Description : This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 15.9kDa
Protein length : Gly2727~Pro2835
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigradefor 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigradefor one month. Aliquot and store at -80 centigradefor 12 months.
Reconstitution : Reconstitute in PBS or others.
Gene Name : FBN1 fibrillin 1 [ Homo sapiens ]
Official Symbol : FBN1
Synonyms : FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS; fibrillin 15; FBN; WMS; MFS1; SSKS; WMS2; ACMICD; GPHYSD2;
Gene ID : 2200
mRNA Refseq : NM_000138
Protein Refseq : NP_000129
MIM : 134797
UniProt ID : P35555
Chromosome Location : 15q21.1
Pathway : Integrin cell surface interactions, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function : calcium ion binding; extracellular matrix structural constituent; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What potential therapeutic applications arise from targeting FBN1 in connective tissue disorders? 06/23/2023

Targeting FBN1 offers potential for treating connective tissue disorders by restoring matrix integrity and function.

How do genetic variations in FBN1 affect connective tissue disorders? 06/08/2023

Genetic mutations in FBN1 can lead to various connective tissue disorders, affecting tissue strength and flexibility.

What is the impact of altered FBN1 activity on cardiovascular health? 02/08/2022

Altered FBN1 activity is associated with cardiovascular conditions due to its role in maintaining blood vessel structure.

What role does FBN1 play in connective tissue development? 02/18/2021

FBN1 plays a critical role in the development of connective tissues, including tendons, ligaments, and blood vessels.

What is the primary role of FBN1 in extracellular matrix formation? 12/29/2019

FBN1, or Fibrillin-1, is essential for the formation of the extracellular matrix, providing structural support to tissues.

How does FBN1 interact with other extracellular matrix proteins? 10/02/2018

FBN1 interacts with other extracellular matrix proteins, such as elastin, in building and maintaining tissue architecture.

How does FBN1 contribute to tissue elasticity and structural integrity? 05/04/2017

It contributes to tissue elasticity and integrity by forming microfibrils that reinforce the matrix.

Customer Reviews (3)

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Reviews
10/12/2022

    Excellent in cell culture functionality

    05/03/2020

      Exceptional specificity in immunohistochemistry

      04/14/2020

        Highly stable and reliable in assays

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