Recombinant Bovine FBN1 protein(2732-2871aa), His-tagged

• Cat.No.: FBN1-753B
• Product Overview: Recombinant Bovine FBN1 protein(P98133)(2732-2871aa), fused with N-terminal His tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Bovine
• Tag: N-His
• Protein length: 2732-2871aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 20.0 kDa
• AASequence: SANETDASNIEDQPEIEANVSLASW DVEKTAVFAFNISHISNKVRILELL PALTTLTNHNRYLIESGNENGFFKI NQKEGISYLHFTKKKPVAGTYSLQI SSTPLYKKKELNQLEDKYDKDYLSG ELGDNLKMKIQILLH
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Reviews

10/12/2022

Excellent in cell culture functionality

05/03/2020

Exceptional specificity in immunohistochemistry

04/14/2020

Highly stable and reliable in assays

Q&As

What potential therapeutic applications arise from targeting FBN1 in connective tissue disorders?

Targeting FBN1 offers potential for treating connective tissue disorders by restoring matrix integrity and function.

How do genetic variations in FBN1 affect connective tissue disorders?

Genetic mutations in FBN1 can lead to various connective tissue disorders, affecting tissue strength and flexibility.

What is the impact of altered FBN1 activity on cardiovascular health?

Altered FBN1 activity is associated with cardiovascular conditions due to its role in maintaining blood vessel structure.

What role does FBN1 play in connective tissue development?

FBN1 plays a critical role in the development of connective tissues, including tendons, ligaments, and blood vessels.

What is the primary role of FBN1 in extracellular matrix formation?

FBN1, or Fibrillin-1, is essential for the formation of the extracellular matrix, providing structural support to tissues.

How does FBN1 interact with other extracellular matrix proteins?

FBN1 interacts with other extracellular matrix proteins, such as elastin, in building and maintaining tissue architecture.

How does FBN1 contribute to tissue elasticity and structural integrity?

It contributes to tissue elasticity and integrity by forming microfibrils that reinforce the matrix.