fbxo32
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  • Official Full Name
  • F-box protein 32
  • Background
  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • FBXO32; F-box protein 32; F box only protein 32; F-box only protein 32; ATROGIN1; Fbx32; MAFbx; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; Atrophy gene 1; FBX32_HUMAN; fbxo25; FLJ32424; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein
Cat.#:FBXO32-237HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBXO32 Protein, His-tagged
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Cat.#:FBXO32-3936HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBXO32 Protein, GST-tagged
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Cat.#:FBXO32-12796HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBXO32, GST-tagged
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Cat.#:FBXO32-22HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBXO32 protein, His-tagged
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Cat.#:FBXO32-28812THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FBXO32
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Cat.#:FBXO32-5744MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FBXO32 Protein
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Cat.#:FBXO32-2295RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FBXO32 Protein
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Cat.#:FBXO32-1663RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FBXO32 Protein, His-tagged
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Cat.#:FBXO32-2644CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FBXO32
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Cat.#:FBXO32-11158ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FBXO32
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Cat.#:FBXO32-6297HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FBXO32 293 Cell Lysate
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Involved Pathway

FBXO32 involved in several pathways and played different roles in them. We selected most pathways FBXO32 participated on our site, such as FoxO family signaling, FoxO signaling pathway, Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO32 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO family signaling
CSNK1G3; CSNK1G2; GADD45A; FBXO32; ZFAND5; MST1
FoxO signaling pathway
TGFB1A; GRM1; HOMER2; AGAP2; TGFBR2; G6PCA.1; SKP2; HRAS; AKT3A; PTENA
Monoamine Transport
TGFB1I1; FBXO32; HRH3; TPH2; SYN1; DBH; SCAMP2; UNC13B

Protein Function

FBXO32 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO32 itself. We selected most functions FBXO32 had, and list some proteins which have the same functions with FBXO32. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein ZBTB8A; TLR2; ZMYND10; RRAD; JUND; SIX3; OSBPL1A; LILRB3; SNX7; ANXA1

Interacting Protein

FBXO32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO32 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO32.
EIF3F; MYOG; MLH1; SKP1; KDM2A

FBXO32 Related Articles

Ma, L; Shen, CA; et al. EXTRACELLULAR SIGNAL-REGULATED KINASE-MAMMALIAN TARGET OF RAPAMYCIN SIGNALING AND FORKHEAD-BOX TRANSCRIPTION FACTOR 3A PHOSPHORYLATION ARE INVOLVED IN TESTOSTERONE'S EFFECT ON SEVERE BURN INJURY IN A RAT MODEL. SHOCK 43:85-91(2015).
Cappelletti, C; Galbardi, B; et al. Autophagy, Inflammation and Innate Immunity in Inflammatory Myopathies. PLOS ONE 9:-(2014).