fgf14
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  • Official Full Name
  • fibroblast growth factor 14
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms
  • FGF14; fibroblast growth factor 14; FHF4; SCA27; MGC119129; MGC129319; bA397O8.2; FHF 4; Fibroblast growth factor homologous factor 4; mFHF-4(1B); MGC129318; RP11-397O8.6; FHF-4; FGF-14
Cat.#:FGF14-4104HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGF14 Protein, GST-tagged
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Cat.#:FGF14-566HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF14 Protein
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Cat.#:FGF14-7617HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF14, His-tagged
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Cat.#:FGF14-5842MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGF14 Protein
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Cat.#:FGF14-2327RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGF14 Protein
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Cat.#:fgf14-169CTag:N/A
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine fgf14
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Cat.#:FGF14-6341CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGF14
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Cat.#:FGF14-2036ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGF14
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Cat.#:FGF14-6246HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FGF14 293 Cell Lysate
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Cat.#:FGF14-6247HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FGF14 293 Cell Lysate
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Involved Pathway

FGF14 involved in several pathways and played different roles in them. We selected most pathways FGF14 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PRKACAB; FGF2; CASP3B; FGF20; PRKCG; STK3; HSPA8; MAP3K12; CACNA1C; PRKACA
Ras signaling pathway
NGFR; GNB3; GNG10; PAK1; RRAS2; GRB2; PRKCA; RASAL1; RAB5C; SHOC2
Rap signaling pathway
TLN1; F2RL3; INS2; MAP2K6; PARD6A; INS1; Itgam&Itgb2; PRKCB; VEGFB; KLK1B4
PIK-Akt signaling pathway
THBS2; GNG12; YWHAB; NOS3; AKT1; GNG7; FGF7; ITGB6; EPOR; KIT
Regulation of actin cytoskeleton
NRAS; LIMK1; PPP1CBL; TMSB; ITGA7; MAPK3; APC; FGF18A; PIP5K1C; ITGA2B
Pathways in cancer
PDGFRB; FZD6; FZD5; TPM3; WNT6; ARHGEF1; RAC2; GNG8; RUNX1; TRAF3
Melanoma
PIK3R1; Pdgfa&Pdgfb; FGF19; PIK3CG; TRP53; FGF18; PIK3R5; FGF10; HGF; PIK3CD

Protein Function

FGF14 has several biochemical functions, for example, NOT fibroblast growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF14 itself. We selected most functions FGF14 had, and list some proteins which have the same functions with FGF14. You can find most of the proteins on our site.
Function
Related Protein
Function NOT fibroblast growth factor receptor binding
Related Protein FGF14; FGF12
Function growth factor activity
Related Protein BMP8A; TGFB1; GDF7; MIA1; BMP4; NDP; CSF2; LEP; LIF; FGF1B
Function heparin binding
Related Protein CCL5; CXCL13; ABP1; CXCL6; PDCD5; MPO; Itgam&Itgb2; APOH; CCDC80; RSPO3

Interacting Protein

FGF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF14.
HIST1H3D

FGF14 Related Articles

Hsu, WC; Nenov, MN; et al. Identifying a Kinase Network Regulating FGF14:Nav1.6 Complex Assembly Using Split-Luciferase Complementation. PLOS ONE 10:-(2015).
Yan, HD; Pablo, JL; et al. FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons. ELIFE 3:-(2014).