fgf5
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  • Official Full Name
  • fibroblast growth factor 5
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • FGF5; fibroblast growth factor 5; heparin-binding growth factor 5; HBGF-5; Smag-82
Cat.#:FGF5-4114HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGF5 Protein, GST-tagged
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Cat.#:FGF5-172HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 5
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Cat.#:FGF5-28880THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF5
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Cat.#:FGF5-501HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF5 Protein, His/GST-tagged
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Cat.#:FGF5-5854MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGF5 Protein
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Cat.#:FGF5-2334RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGF5 Protein
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Cat.#:FGF5-1951ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGF5
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Cat.#:FGF5-6238HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FGF5 293 Cell Lysate
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Cat.#:FGF5-6239HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FGF5 293 Cell Lysate
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Involved Pathway

FGF5 involved in several pathways and played different roles in them. We selected most pathways FGF5 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
Fasl; STMN1B; RASA1; NF1; LAMTOR3; MAP3K3; FGF6B; GRB2; FGF8; MECOM
Ras signaling pathway
PAK2; RAC1; PIK3CD; RALGDS; SHOC2; HRAS; GNG13; CALM3; STK4; PGF
Rap signaling pathway
KITLG; PRKD1; FGF3; APBB1IP; GRIN2B; MAP2K3; FGF17; INSR; FGF4; Itgam&Itgb2
PIK-Akt signaling pathway
CD19; INS1; PPP2R5B; GNGT1; PIK3CA; INS2; IFNA21; TRP53; BAD; YWHAB
Regulation of actin cytoskeleton
PPP1CBL; RAC1A; FGF18; PIK3CD; PIK3CG; FN1; CYFIP1; HRASB; PIK3R1; RHOAD
Pathways in cancer
FZD3; KIT; FGF19; MAX; IL6; CYCS; GLI1; RAC2; PDGFA; FLT3
Melanoma
HRAS; PDGFC; FGF18; PIK3CG; Fgf15; FGF20; TP53; PDGFA; IGF1R; MAP2K1

Protein Function

FGF5 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF5 itself. We selected most functions FGF5 had, and list some proteins which have the same functions with FGF5. You can find most of the proteins on our site.
Function
Related Protein
Function fibroblast growth factor receptor binding
Related Protein Fgf15; FRS2; FGF22; FGF3; FGF6A; FGF8; FGF5; FGF1; FGF10B; FGF18A
Function growth factor activity
Related Protein FGF13; PDGFAA; CNTF; FGF18A; BMP8B; ANGPTL3; GDF9; FBRS; BTC; FGF5

Interacting Protein

FGF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF5.
EGF; FGFR2; FGFR4; MAPK1

FGF5 Related Articles

Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).
Hirano, K; Van Kuppevelt, TH; et al. The transition of mouse pluripotent stem cells from the naive to the primed state requires Fas signaling through 3-O sulfated heparan sulfate structures recognized by the HS4C3 antibody. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430:1175-1181(2013).