flt4
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  • Official Full Name
  • Fms-related tyrosine kinase 4
  • Background
  • Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
  • Synonyms
  • Fms-Related Tyrosine Kinase 4; Flt-4; PCL; FLT41; LMPH1A; VEGFR3
Cat.#:FLT4-2055HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT4 Protein, Fc/His-tagged
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Cat.#:FLT4-391MTag:MIgG2a Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FLT4 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:FLT4-4377HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FLT4 Protein, GST/His-tagged
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Cat.#:FLT4-4378HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FLT4 Protein, GST-tagged
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Cat.#:FLT4-4379HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FLT4 Protein, GST-tagged
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Cat.#:FLT4-161HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 4, His-tagged
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Cat.#:FLT4-1698HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 4
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Cat.#:FLT4-238HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT4 protein, His/S-tagged
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Cat.#:FLT4-31718THTag:His
Source (Host):Species:Human
Product nameRecombinant Human FLT4, His-tagged
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Cat.#:FLT4-31719THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FLT4
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Cat.#:FLT4-31720THTag:
Source (Host):Species:Human
Product nameRecombinant Human FLT4
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Cat.#:FLT4-347HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT4 protein, Fc-tagged
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Cat.#:FLT4-37HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT4, His tagged
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Cat.#:FLT4-548HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 4, GST-tagged
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Cat.#:FLT4-583HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 4, Fc Chimera
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Cat.#:FLT4-587HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 4
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Cat.#:FLT4-617HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FLT4, Fc-tagged, Biotinylated
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Cat.#:FLT4-720HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 4, GST-His
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Cat.#:FLT4-8117HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT4 protein, His & Avi-tagged, Biotinylated
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Cat.#:FLT4-85HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, Fc-tagged
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Cat.#:FLT4-86HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, His-tagged
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Cat.#:FLT4-889HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT4, Fc tagged
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Cat.#:FLT4-940HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human FLT4 Protein, DDK/His-tagged
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Cat.#:Flt4-1787MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse FMS-like Tyrosine Kinase 4
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Cat.#:Flt4-1942MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Flt4 protein, His & T7-tagged
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Cat.#:Flt4-239MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Flt4 protein, His/S-tagged
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Cat.#:Flt4-281MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Flt4, Fc tagged
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Cat.#:Flt4-282MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Flt4, His tagged
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Cat.#:FLT4-2365RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FLT4 Protein
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Cat.#:Tnf-240RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Flt4 protein, His-tagged
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Cat.#:FLT4-5522CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FLT4
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Cat.#:FLT4-8585ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FLT4
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Cat.#:FLT4-2709HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT4 cell lysate
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Cat.#:FLT4-2016MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FLT4 cell lysate
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Cat.#:Kit-1594Tag:
Source (Host):Species:
Product nameFlt4 Activity Assay Kit
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Involved Pathway

FLT4 involved in several pathways and played different roles in them. We selected most pathways FLT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
RELA; GNG11; MAP2K2; RASA1; ETS2; PLA2G1B; GNGT1; GNG10; SHC3; GNGT2
Rap signaling pathway
FGF1; HRAS; GRIN1; FLT4; LCP2; ANGPT2; PLCB2; PIK3R3; TLN1; PDGFD
Cytokine-cytokine receptor interaction
TNFRSF1B; TNFSF4; TNFRSF9; BMPR2A; TNFSF13B; IFNA17; CCR9A; FASLG; CCL22; PRL
PIK-Akt signaling pathway
GNG4; FGFR1; GNG12; PPP2R2A; CCND2; STK11; CCNE2; FGF19; IRS1; PPP2R2B
Focal adhesion
FLNC; ACTN3; PDGFD; GRB2; IGF1R; PIK3R1; ARHGAP5; COL4A6; DIAP1; GSK3AA

Protein Function

FLT4 has several biochemical functions, for example, ATP binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT4 itself. We selected most functions FLT4 had, and list some proteins which have the same functions with FLT4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAPKAPK5; CHD4; TARS2; MARK1; SETX; ABCG1; CMPK1; CDC42BPG; PLK2B; PRKCDA
Function growth factor binding
Related Protein OSMR; ACVR2A; NRP1; LTBP4; LTBP2; FLT4; RPL37; GHR; IL6ST; FLT1
Function protein binding
Related Protein RNF40; IL24; RPLP0; MED8; MCCC1; PALM; FAM64A; PSMA5; SMNDC1; HMGA2
Function protein phosphatase binding
Related Protein PPME1; CSK; PPP6R3; TRAF2; KAT2A; RPA2; VCAN; ANAPC4; FLT4; ANAPC5
Function transmembrane receptor protein tyrosine kinase activity
Related Protein EPHA4A; ROR1; DDR2; FGFR1A; ERBB4; ALK; ERBB3A; IGF1RB; FGFR1B; EPHB4
Function vascular endothelial growth factor-activated receptor activity
Related Protein PDGFRA; NRP2; NRP1A; NRP2B; FLT1; NRP2A; FLT3; NRP1B; KDR; FLT4

Interacting Protein

FLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT4.
KDR; HSP90AB1; PKM; LRRK1; IKBKG; VEGFC; ATF7IP

FLT4 Related Articles

Jurisic, G; Sundberg, JP; et al. Blockade of VEGF Receptor-3 Aggravates Inflammatory Bowel Disease and Lymphatic Vessel Enlargement. INFLAMMATORY BOWEL DISEASES 19:1983-1989(2013).
von Kaisenberg, CS; Wilting, J; et al. Lymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls. MOLECULAR HUMAN REPRODUCTION 16:778-789(2010).