FLT4
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Official Full Name
Fms-related tyrosine kinase 4 -
Overview
Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. -
Synonyms
Fms-Related Tyrosine Kinase 4;Flt-4;PCL;FLT41;LMPH1A;VEGFR3
Recombinant Proteins
- Mouse
- Human
- Rat
- Chicken
- Zebrafish
- HEK293
- Human Cells
- Insect Cells
- Mammalian Cells
- Sf21 Cells
- E.coli
- Sf9 Cells
- Wheat Germ
- His
- Fc
- Avi
- Non
- T7
- S
- GST
- Flag
- mFc
Involved Pathway
FLT4 involved in several pathways and played different roles in them. We selected most pathways FLT4 participated on our site, such as Ras signaling pathway,Rap signaling pathway,Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | LPAR4,PRKCG,TEK,SIPA1L1,PFN2,GNAI3,ANGPT1,PRKD3,ACTG1,PLCG1 |
| Ras signaling pathway | RALGDS,PDGFRB,MAP2K1,NGFR,RAPGEF5,VEGFC,ABL2,GNB2,KSR2,PLD2 |
| Cytokine-cytokine receptor interaction | FAS,IL18,Ccl27a,CSH,M17,ACVR1L,AMH,IL18R1,CXCL9,CXCR4 |
| PIK-Akt signaling pathway | Gh,MET,ITGA3,GHR,IL6,PDGFC,STK11,PPP2R2B,MCL1,TNXB |
| Focal adhesion | PDGFRA,ITGB1A,AKT2L,ITGAV,COL5A2,FYN,RAC2,VAV2,THBS3,ACTN2B |
Protein Function
FLT4 has several biochemical functions, for example, ATP binding,growth factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT4 itself. We selected most functions FLT4 had, and list some proteins which have the same functions with FLT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase binding | SHOC2,CDKN1B,HSF4,RPA3,ITPR1,SNX3,STAT3,PPP1R3G,DLG4,EIF2AK3 |
| ATP binding | MAPK14B,P2RY1,CKBA,XRCC5,SLK,HSPA5,YTHDC2,TTLL3,FGFR2,MAPK9 |
| transmembrane receptor protein tyrosine kinase activity | LTK,ROR1,TIE1,EPHB4A,FGFR1B,EPHB2B,EPHA4A,EPHB4,TEK,ERBB3B |
| vascular endothelial growth factor-activated receptor activity | FLT3,PDGFRA,NRP2,NRP2B,KDR,NRP2A,FLT1,NRP1,NRP1B,NRP1A |
| protein binding | RBM15B,FOXP4,PIK3C2B,TACR2,PPP3CA,RHOA,TPM4,GAGE5,RAB2A,GH1 |
| growth factor binding | OSMR,TEK,GHRHR,HTRA1B,ACVR1C,NRP2,LTBP2,GHR,KDR,NRP1 |
Interacting Protein
FLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT4.
KDR;HSP90AB1;PKM;LRRK1;IKBKG;VEGFC;ATF7IP
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References
- Jurisic, G; Sundberg, JP; et al. Blockade of VEGF Receptor-3 Aggravates Inflammatory Bowel Disease and Lymphatic Vessel Enlargement. INFLAMMATORY BOWEL DISEASES 19:1983-1989(2013).
- von Kaisenberg, CS; Wilting, J; et al. Lymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls. MOLECULAR HUMAN REPRODUCTION 16:778-789(2010).
