foxp3
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  • Official Full Name
  • forkhead box P3
  • Background
  • The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FOXP3; forkhead box P3; JM2; AIID; IPEX; PIDX; XPID; DIETER; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked;
Cat.#:FOXP3-1216HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOXP3 Protein, His-tagged
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Cat.#:FOXP3-50HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOXP3, MYC/DDK-tagged
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Cat.#:FOXP3-51HTag:GST
Source (Host):Species:Human
Product nameRecombinant Human Forkhead box P3, GST-tagged
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Cat.#:FOXP3-52HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human Forkhead box P3, GST-tagged
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Cat.#:FOXP3-53HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOXP3 protein, His-tagged
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Cat.#:Foxp3-1919MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Foxp3 protein, His & GST-tagged
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Cat.#:FOXP3-1746RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FOXP3 Protein, His-tagged
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Cat.#:FOXP3-6145HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FOXP3 293 Cell Lysate
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Involved Pathway

FOXP3 involved in several pathways and played different roles in them. We selected most pathways FOXP3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inflammatory bowel disease (IBD)
Il23a; Il12b; HLA-DRB1; HLA-DQB1; IL18; IL12A; HLA-DQA1; IL22; SMAD3; IL18RAP; HLA-DRA

Protein Function

FOXP3 has several biochemical functions, for example, NF-kappaB binding, NFAT protein binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXP3 itself. We selected most functions FOXP3 had, and list some proteins which have the same functions with FOXP3. You can find most of the proteins on our site.
Function
Related Protein
Function NF-kappaB binding
Related Protein ANXA4; BCL10; ANKRD42; NFKBIA; RNF25; HIF1AN; EP300; SNAI1A; NPM1; COMMD7
Function NFAT protein binding
Related Protein FOXP3; GATA4; PPARA; MAPK14; SFPI1; SPI1
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXM1; ZSCAN1; ELF2A; TAL1; FOXC1B; TP53; POU5F1; JUND; SPI1; ETV5A
Function core promoter binding
Related Protein CLOCK; E2F2; E2F1; HNRNPU; GTF2B; DHX36; RBMX; EZH2; E2F3; MYBBP1A
Function histone acetyltransferase binding
Related Protein TRIP4; MEF2A; CREB1; PAX6; CITED2; TAF7L; GLI3; KAT2B; FOXP3; TRIM68
Function histone deacetylase binding
Related Protein KAT2A; RAD9A; CEBPB; SP2; HIST1H1B; ANKRA2; NUDT21; KPNA2; HES1; RFXANK
Function metal ion binding
Related Protein ZFP598; ZNF843; PHF23B; ZNF572; TPH1B; ZNF615; TTC4; ZNF323; TRIM35-29; NT5C3L
Function protein binding
Related Protein MAPK8; TRIM69; ALG2; RAB38; NOL12; KDM4A; RABGAP1; HYPM; MT1X; SKIL
Function protein homodimerization activity
Related Protein SLC4A1; CAMK2A; IRAK2; MECOM; OXA1L; DNM1L; DMRT2B; PVR; S100A11; SPPL2B
Function sequence-specific DNA binding
Related Protein RORAA; GZF1; RARAB; ESX1; ZBTB33; GSX2; ZNF263; MAFF; NKX6.1; NR1D4A
Function transcription corepressor activity
Related Protein ATF5; SKIL; SKOR1B; PSMC3; E2F7; WNT4; WWTR1; IRF2BP2; TBL1Y; SSX5
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein SPI1; PDX1; TFAP4; NKX2-1; T; TEAD2; MEIS1; CEBPA; SOX7; THRA
Function transcription factor activity, sequence-specific DNA binding
Related Protein TEAD4; SMAD3B; SCAND3; HOXB4A; HOMEZB; SP140; CDX2; MYCB; HOXB6B; ZBTB14

Interacting Protein

FOXP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXP3.
PRR20C; RBPMS; IKZF3; mouse_arre2_site_il2_promoter_1; HDAC7; IKZF3; HDAC9; arre2_element_mouse_il2_promoter; Ctla4; il2ra_mouse_gene; Il2; RORC

FOXP3 Related Articles

Martinson, HA; Jindal, S; et al. Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression. INTERNATIONAL JOURNAL OF CANCER 136:1803-1813(2015).
Kaser, T; Mair, KH; et al. Natural and inducible Tregs in swine: Helios expression and functional properties. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 49:323-331(2015).