gad1
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  • Official Full Name
  • glutamate decarboxylase 1 (brain, 67kDa)
  • Background
  • Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L-glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD67 is a cytoplasmic protein and is encodes on chromosome 2.
  • Synonyms
  • GAD1; glutamate decarboxylase 1 (brain, 67kDa); GAD, glutamate decarboxylase 1 (brain, 67kD); glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform; GAD; SCP; CPSQ1; FLJ45882
Cat.#:GAD1-4653HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GAD1 Protein, GST-tagged
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Cat.#:GAD1-936HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GAD1 Protein, MYC/DDK-tagged
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Cat.#:GAD1-1180HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GAD1, His tagged
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Cat.#:GAD1-149HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAD1, His-tagged
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Cat.#:GAD1-26511THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GAD1
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Cat.#:GAD1-615HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human glutamate decarboxylase 1 (brain, 67kDa), His-tagged
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Cat.#:GAD1-6160MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GAD1 Protein
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Cat.#:Gad1-8148MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gad1 protein, His & S-tagged
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Cat.#:Gad1-8149MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gad1 protein, His & GST-tagged
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Cat.#:Gad1-8150RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gad1 protein, His & S-tagged
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Cat.#:GAD1-6475CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GAD1
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Cat.#:GAD1-586HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GAD1 cell lysate
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Involved Pathway

GAD1 involved in several pathways and played different roles in them. We selected most pathways GAD1 participated on our site, such as Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alanine, aspartate and glutamate metabolism
DDO; GLS; ADSL; GAD1; ASS1; ABAT; CPS1; GLUD1B; ALDH4A1; PPAT
beta-Alanine metabolism
HADHAB; ALDH7A1; ALDH3A2A; ALDH3B1; ALDH3B2; ALDH3A2; AOC3; ALDH3A1; ALDH9A1B; ALDH1B1
Taurine and hypotaurine metabolism
CSAD; BAAT; GAD1B; ADOB; GGT1A; GGT1; GGT5; CDO1; ADO; GAD1
Butanoate metabolism
DHRS13L1; ACSM4; GAD2; ACSM1; ACSM3; HADHA; AACS; OXCT2A; OXCT1A; HMGCS2
Metabolic pathways
UPRT; NAT1; MTMR6; PEMT; DPM2; GBA; PIGC; CYP26C1; CAD; GMDS
GABAergic synapse
GLUL; GABRQ; GNG3; SLC6A13; GAD2; GABRP; PRKCB; GNB4; GNGT2; GABBR1
Type I diabetes mellitus
ICA1; INS2; HLA-A; H2-Q10; HLA-DQA2; HLA-DQA1; IL1B; HLA-G; HLA-DRB3; Il2

Protein Function

GAD1 has several biochemical functions, for example, glutamate decarboxylase activity, protein binding, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAD1 itself. We selected most functions GAD1 had, and list some proteins which have the same functions with GAD1. You can find most of the proteins on our site.
Function
Related Protein
Function glutamate decarboxylase activity
Related Protein GAD2; GAD1B; GAD1; GLUL
Function protein binding
Related Protein ALDH3B1; VEGFB; GAST; TCTN2; TUBA3D; HSPB7; BCL9; FKBP1A; UNC13B; POGK
Function pyridoxal phosphate binding
Related Protein KYNU; SHMT1; SRR; OAT; SGPL1; PYGMA; PYGB; PYGMB; CTH; PYGL

Interacting Protein

GAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAD1.
HAAO; CMTM5; STK3; AGTRAP; ABL1; JUN; FYN; NCK1; GRB2

GAD1 Related Articles

Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
Jaraj, SJ; Augsten, M; et al. GAD1 is a biomarker for benign and malignant prostatic tissue. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 45:39-45(2011).