| Description : |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
66.9 kDa |
| AA Sequence : |
MASSTPSSSATSSNAGADPNTTNLR PTTYDTWCGVAHGCTRKLGLKICGF LQRTNSLEEKSRLVSAFKERQSSKN LLSCENSDRDARFRRTETDFSNLFA RDLLPAKNGEEQTVQFLLEVVDILL NYVRKTFDRSTKVLDFHHPHQLLEG MEGFNLELSDHPESLEQILVDCRDT LKYGVRTGHPRFFNQLSTGLDIIGL AGEWLTSTANTNMFTYEIAPVFVLM EQITLKKMREIVGWSSKDGDGIFSP GGAISNMYSIMAARYKYFPEVKTKG MAAVPKLVLFTSEQSRYSIKKAGAA LGFGTDNVILIKCNERGEIIPADFE AKILEAKQKGYVPFYVNATAGTTVY GAFDPIQEIADICEKYNLWLHVDAA WGGGLLMSRKHRHKLNGIERANSVT WNPHKMMGVLLQCSAILVKEKGILQ GCNQMCAGYLFQPDKQYDVSYDTGD KAIQCGRHVDIFKFWLMWKAKGTVG FENQINKCLELAEYLYAKIKNREEF EMVFNGEPEHTNVCFWYIPQSLRGV PDSPQRREKLHKVAPKIKALMMESG TTMVGYQPQGDKANFFRMVISNPAA TQSDIDFLIEEIERLGQDLTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
