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Recombinant Human GAD1 Protein, GST-tagged

Cat.No. : GAD1-4653H
Product Overview : Human GAD1 full-length ORF ( AAH26349, 1 a.a. - 594 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 91.08 kDa
AA Sequence : MASSTPSSSATSSNAGADPNTTNLR PTTYDTWCGVAHGCTRKLGLKICGF LQRTNSLEEKSRLVSAFKERQSSKN LLSCENSDRDARFRRTETDFSNLFA RDLLPAKNGEEQTVQFLLEVVDILL NYVRKTFDRSTKVLDFHHPHQLLEG MEGFNLELSDHPESLEQILVDCRDT LKYGVRTGHPRFFNQLSTGLDIIGL AGEWLTSTANTNMFTYEIAPVFVLM EQITLKKMREIVGWSSKDGDGIFSP GGAISNMYSIMAARYKYFPEVKTKG MAAVPKLVLFTSEQSHYSIKKAGAA LGFGTDNVILIKCNERGKIIPADFE AKILEAKQKGYVPFYVNATAGTTVY GAFDPIQEIADICEKYNLWLHVDAA WGGGLLMSRKHRHKLNGIERANSVT WNPHKMMGVLLQCSAILVKEKGILQ GCNQMCAGYLFQPDKQYDVSYDTGD KAIQCGRHVDIFKFWLMWKAKGTVG FENQINKCLELAEYLYAKIKNREEF EMVFNGEPEHTNVCFWYIPQSLRGV PDSPQRREKLHKVAPKIKALMMESG TTMVGYQPQGDKANFFRMVISNPAA TQSDIDFLIEEIERLGQDL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : GAD1 glutamate decarboxylase 1 (brain, 67kDa) [ Homo sapiens ]
Official Symbol : GAD1
Synonyms : GAD1; glutamate decarboxylase 1 (brain, 67kDa); GAD, glutamate decarboxylase 1 (brain, 67kD); glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform; GAD; SCP; CPSQ1; FLJ45882;
Gene ID : 2571
mRNA Refseq : NM_000817
Protein Refseq : NP_000808
MIM : 605363
UniProt ID : Q99259

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is GAD1 protein studied at the molecular level in clinical research? 06/08/2022

Molecular techniques such as PCR (Polymerase Chain Reaction) and genetic sequencing are employed to investigate mutations and variations in the GAD1 gene.

How does GAD1 relate to anxiety disorders? 03/13/2022

Altered GAD1 function can disrupt the balance of GABAergic neurotransmission, potentially contributing to the development or exacerbation of anxiety disorders.

Are there any therapeutic implications for targeting GAD1 in neurological disorders? 11/09/2018

Investigating GAD1 as a therapeutic target may offer novel approaches to modulate GABAergic signaling and manage conditions associated with its dysregulation.

Can changes in GAD1 expression be used as a biomarker for certain disorders? 04/13/2018

In some cases, alterations in GAD1 expression levels have been proposed as potential biomarkers for specific neurological and psychiatric disorders.

Can genetic variations in GAD1 influence disease susceptibility? 02/28/2017

Yes, genetic polymorphisms in the GAD1 gene have been identified, and variations may influence an individual's susceptibility to certain neurological and psychiatric disorders.

Customer Reviews (3)

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Reviews
03/30/2021

    One advantage of using GAD1 protein in trials is its versatility.

    06/25/2020

      GAD1 is a key regulator of cellular structure and function, particularly in the context of maintaining the integrity of the cell membrane and organizing cytoskeletal components.

      01/03/2020

        GAD1 can be used in various experimental setups and assays, including in vitro cell culture studies, animal models, and even clinical investigations.

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