gata2
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  • Official Full Name
  • GATA binding protein 2
  • Background
  • This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  • Synonyms
  • GATA2; GATA binding protein 2; DCML; IMD21; NFE1B; MONOMAC; endothelial transcription factor GATA-2;
Cat.#:GATA2-4745HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GATA2 Protein, GST-tagged
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Cat.#:GATA2-136HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GATA2 protein, Arginine-tagged
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Cat.#:GATA2-28285THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GATA2
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Cat.#:GATA2-28983THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GATA2
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Cat.#:GATA2-476HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GATA2 Protein, His-tagged
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Cat.#:Gata2-477MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gata2 Protein, His-tagged
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Cat.#:GATA2-6223MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GATA2 Protein
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Cat.#:GATA2-1186CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GATA2
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Cat.#:GATA2-6013HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GATA2 293 Cell Lysate
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Involved Pathway

GATA2 involved in several pathways and played different roles in them. We selected most pathways GATA2 participated on our site, such as Adipogenesis, Factors involved in megakaryocyte development and platelet production, HIF-1-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adipogenesis
HMGA1-RS1; CEBPB; CYP26A1; NAMPT; MIXL1; EPAS1B; CELF1; CNTFR; GADD45A; FOXC2
Factors involved in megakaryocyte development and platelet production
HBB-BH1; KIF3A; BA2; DOCK6; H3F3B.1; HBBE3; DOCK8; KIF2C; CENPE; KIF4A
HIF-1-alpha transcription factor network
PLIN2; NPM1; GATA2; TFF3; CITED2; COPS5; NDRG1; ENG; EGLN3; ADM
Hemostasis
BA2; CFHL3; SIRPA; APOA1B; CFHL1; PLEK; MERTK; GAS6; BRPF3; GATA2
IL-3 Signaling Pathway
BIRC5A; GATA1; GATA2; KCNIP3B; KCNIP3; CISH; PILRB; GSK3AB; GATA2A; GATA1A
Regulation of Androgen receptor activity
NR2C1; KAT7; SMARCA2; SENP1; SMARCE1; SRY; SPDEF; HOXB13; TRIM24; APPBP2
SIDS Susceptibility Pathways
LMX1B; TSPYL1; DEAF1; PHOX2A; POU2F2; TPPP; DLX2; IL1RN; SP3; CREM
Signaling events mediated by HDAC Class I
WDR77; SIRT4; NR2C1; GATA1; GATA2; SIRT5; SIRT2; MXD1; SIRT7; PRMT5

Protein Function

GATA2 has several biochemical functions, for example, C2H2 zinc finger domain binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA2 itself. We selected most functions GATA2 had, and list some proteins which have the same functions with GATA2. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein THAP7; EBF1; LEF1; HMGA2; EHMT2; U2AF2; ZXDC; TAF9; GATA1; WT1
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein TAL1; NFATC1; PBX3; ATF2; RXRB; NFE2L2; BACH1A; NONO; NR2F6; ESRRB
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein AASS; CDX1B; GATA1; FOXD3; AIRE; HES6; SP5; BHLHA15; ZNF549; E2F7
Function RNA polymerase II transcription factor binding
Related Protein TBX6; ID4; TBX20; GATA1A; GSC; MTDH; MIXL1; XBP1; GATA2; MKX
Function chromatin binding
Related Protein UBTF; RAG2; NR5A5; RUNX2; CNBPA; POU2F1; MB21D2; DNMT1; GM606; NKX6-1
Function enhancer sequence-specific DNA binding
Related Protein SOX9; ATF2; TBX19; GATA1; XBP1; HMGB2; FOXN4; LMO4; TFAP2B; GATA3
Function protein binding
Related Protein BRCA1; STX12; NFKBIZ; HIST1H3F; TRAK1; SPI1; ZCCHC7; ADIPOQ; ZFP64; TIFA
Function transcription factor activity, sequence-specific DNA binding
Related Protein TAF13; LCOR; TEAD3; NR1H5; CLOCKA; SPI1B; LEF1; POU3F3; MESPBA; HOXA3A
Function transcription factor binding
Related Protein ERCC3; NEUROD1; SMARCD3; ZBTB49; PPRC1; PRKDC; SNF8; SOST; PPP1R13BB; NCOR2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HNF4A; SP1; SREBF1; EBF3A; BSX; OTX1; SRF; ONECUT3; NR5A2; EGR2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ALX4; PAX9; GATA1A; CSRNP1; GRHL3; EP300; ONECUT3; CEBPA; MAFK; NHLH1
Function zinc ion binding
Related Protein CAR13; TRIM5; RNF128A; NR4A2A; RARGA; EHMT1B; PRICKLE2A; TP53; RPS29; SLC30A8

Interacting Protein

GATA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA2.
Lmo2; PSMA3; TRIM23; KRTAP10-9; PRR20C; GOLGA2

GATA2 Related Articles

Plymate, SR; Bhatt, RS; et al. Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2. CANCER CELL 27:158-159(2015).
Chou, J; Lutskiy, M; et al. Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:223-226(2014).