GDF11
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Official Full Name
growth differentiation factor 11
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Overview
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. -
Synonyms
GDF11; growth differentiation factor 11; growth/differentiation factor 11; BMP 11; GDF-11; bone morphogenetic protein 11; BMP11; BMP-11;
- Recombinant Proteins
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Human/Mouse/Rat
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His(C
- ter)
- SUMO
- Met
- N/A
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- GDF11 Related Gene Family
GDF11 involved in several pathways and played different roles in them. We selected most pathways GDF11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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GDF11 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF11 itself. We selected most functions GDF11 had, and list some proteins which have the same functions with GDF11. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | IFNA10;CD40LG;IFNPHI1;IFNL3;IL36A;IL22;IFNA2;IFNA8;MSTNB |
growth factor activity | GMFB;FGF6;IL5;PRL2C3;FGF20A;GDNF;CXCL12;FGF13B;JAG1 |
transforming growth factor beta receptor binding | BMP2B;GDF7;BMP10;GDF9;TGFB1A;SMAD3;BMP8A;NDR1;BMP2 |
GDF11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF11 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF11.
ACVR2B; Acvr1b; Tgfbr1; Acvr1c; WFIKKN2; WFIKKN1
- Q&As
- Reviews
Q&As (6)
Ask a questionThe protein can be used to treat some diseases through stem cell therapy, such as using the promoter of GDF11 to activate the self-renewal and regenerative ability of stem cells.
GDF11 protein can be used as a therapeutic target for a variety of diseases such as muscular dystrophy, osteoporosis, cardiovascular diseases and neurodegenerative diseases.
GDF11 protein inhibits the differentiation of well-developed chondrocytes in bone growth plates into osteoblasts, thereby inhibiting bone growth.
The GDF11 protein can be intervened by means of drugs, such as using soluble GDF11 receptors to increase the activity of the GDF11 signaling pathway.
In young animals, GDF11 promotes muscle growth, but in older adults and mice, its effect is not significant.
This protein promotes the production and growth of neuroblasts and also plays an important role in the differentiation and function of neural stem cells.
Customer Reviews (3)
Write a reviewThe repeatability of GDF11 is very good, which can ensure the reliability of the experimental results, and also facilitate the subsequent research and application.
After using GDF11, my experimental results are more stable and reliable, and also convenient for subsequent data analysis.
The band intensity of GDF11 in Western blot was high, which improved the signal-to-noise ratio of the experiment.
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