gpt
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  • Official Full Name
  • glutamic-pyruvate transaminase (alanine aminotransferase)
  • Background
  • This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
  • Synonyms
  • GPT; glutamic-pyruvate transaminase (alanine aminotransferase); alanine aminotransferase 1; ALT1; GPT1; AAT1; Alanine aminotransferase; ALAT1_HUMAN; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; OTTHUMP00000228783; glutamic-alanine transaminase 1
Cat.#:GPT-2236HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPT Protein, MYC/DDK-tagged
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Cat.#:GPT-5304HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GPT Protein, GST-tagged
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Cat.#:GPT-1283HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutamic-Pyruvate Transaminase (Alanine Aminotransferase), His-tagged
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Cat.#:GPT-26390THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPT, His-tagged
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Cat.#:GPT-33HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPT
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Cat.#:GPT-59HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPT protein, His-tagged
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Cat.#:Gpt-131MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gpt protein, His-tagged
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Cat.#:Gpt-203MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gpt Protein, His-tagged
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Cat.#:ALT-3248RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat ALT, His-tagged
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Cat.#:Gpt-206RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gpt Protein, His-tagged
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Cat.#:GPT-2676RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GPT Protein
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Cat.#:Gpt-294RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Gpt, His tagged
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Cat.#:Gpt-44RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gpt protein, His-tagged
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Cat.#:GPT-1964RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GPT Protein, His-tagged
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Cat.#:GPT-204PTag:His|GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig GPT Protein, His/GST-tagged
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Cat.#:GPT-1840HTag:N/A
Source (Host):Human liverSpecies:Human
Product nameNative Human GPT
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Cat.#:GPT-187HTag:N/A
Source (Host):Human HeartSpecies:Human
Product nameNative Human Glutamate Pyruvate Transaminase
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Cat.#:GPT-26879THTag:N/A
Source (Host):Species:Human
Product nameNative Human GPT
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Cat.#:GPT-26882THTag:N/A
Source (Host):Species:Human
Product nameNative Human GPT
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Cat.#:GPT-5344HTag:N/A
Source (Host):Human liverSpecies:Human
Product nameNative Human Glutamic-Pyruvate Transaminase (alanine aminotransferase)
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Cat.#:GPT-65HTag:N/A
Source (Host):Species:Human
Product nameNative Human Glutamate Pyruvate Transaminase (GPT)
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Cat.#:GPT-188STag:N/A
Source (Host):Porcine HeartSpecies:Pig
Product nameNative Swine Glutamate Pyruvate Transaminase
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Cat.#:GPT-189PTag:N/A
Source (Host):Porcine HeartSpecies:Porcine
Product nameNative Porcine GPT protein
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Cat.#:GPT-721RCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat GPT cell lysate
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Involved Pathway

Gpt involved in several pathways and played different roles in them. We selected most pathways Gpt participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gpt were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine biosynthesis
OTC; ACY1; GLULC; NOS2; ybaS; ASS1; GPT2L; ASL; GOT2B; GPT
Alanine, aspartate and glutamate metabolism
CPS1; GLULA; AGXTB; ASL; GAD2; ASPA; ASL2; GOT2B; ADSSL; DDO
Metabolic pathways
PLB1; AKR1B1; SDSL; ALDH3A1; HIBCH; TH; CEPT1; CDIPT; MGAT4A; POLR2D
Carbon metabolism
TPI1A; PGK1; SDHC; ACO2; PCCB; HAO1; DLDH; IDH3A; GPI1; ANI_1_2390104
-Oxocarboxylic acid metabolism
ACO1; ACO2; GPT; GPT2; ACY1; IDH2; IDH3G; GOT2B; GOT2A; GOT1
Biosynthesis of amino acids
PKLR; ENO1; OTC; BCAT1; GLULC; PFKP; GLULA; TPI1; TAT; RPIA

Protein Function

Gpt has several biochemical functions, for example, L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gpt itself. We selected most functions Gpt had, and list some proteins which have the same functions with Gpt. You can find most of the proteins on our site.
Function
Related Protein
Function L-alanine:2-oxoglutarate aminotransferase activity
Related Protein GPT2L; GPT; GPT2
Function pyridoxal phosphate binding
Related Protein CCBL2; DDC; GCAT; ETNPPL; PROSC; THNSL2; PDXK; SPTLC2; GOT2B; MOSC2

Interacting Protein

Gpt has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gpt here. Most of them are supplied by our site. Hope this information will be useful for your research of Gpt.
CDC7; RALA; SASS6

Gpt Related Articles

Selleng, S; Selleng, K; et al. Prevalence and clinical implications of anti-PF4/heparin antibodies in intensive care patients: a prospective observational study. JOURNAL OF THROMBOSIS AND THROMBOLYSIS 39:60-67(2015).
Zhang, FS; Chen, WQ; et al. Transcriptional activity comparison of different sites in recombinant Marek's disease virus for the expression of the H9N2 avian influenza virus hemagglutinin gene. JOURNAL OF VIROLOGICAL METHODS 207:138-145(2014).