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Gpt

  • Official Full Name

    glutamic-pyruvate transaminase (alanine aminotransferase)

  • Overview

    This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
  • Synonyms

    GPT; glutamic-pyruvate transaminase (alanine aminotransferase); alanine aminotransferase 1; ALT1; GPT1; AAT1; Alanine aminotransferase; ALAT1_HUMAN; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; OTTHUMP00000228783; glutamic-alanine transaminase 1;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Heart
  • Human Liver
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Porcine Heart
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPT-33H Active Recombinant Human GPT E.coli N/A
Human GPT-59H Active Recombinant Human GPT protein, His-tagged E.coli His
Human GPT-65H Active Native Human Glutamate Pyruvate Transaminase (GPT) Human Heart N/A
Human GPT-187H Active Native Human Glutamate Pyruvate Transaminase Human Heart N/A
Human GPT-1840H Active Native Human GPT Human Liver N/A
Human GPT-26390TH Recombinant Human GPT, His-tagged E.coli His 496 amino acids
Human GPT-1283H Recombinant Human Glutamic-Pyruvate Transaminase (Alanine Aminotransferase), His-tagged Human His
Human GPT-5304H Recombinant Human GPT Protein, GST-tagged Wheat Germ GST
Human GPT-1015H Recombinant Human GPT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GPT-5572HF Recombinant Full Length Human GPT Protein, GST-tagged In Vitro Cell Free System GST 496 amino acids
Human GPT-2236H Recombinant Human GPT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GPT-5420H Recombinant Human GPT protein, His-tagged Yeast His 2-496aa
Human GPT-26879TH Native Human GPT N/A
Human GPT-1066HFL Recombinant Full Length Human GPT Protein, C-Flag-tagged Mammalian cells Flag
Human GPT-4845H Recombinant Human GPT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GPT-1015H-B Recombinant Human GPT Protein Pre-coupled Magnetic Beads HEK293
Human GPT-3348H Recombinant Human GPT Protein (Pro367-Leu480), N-His tagged E.coli N-His Pro367-Leu480
Human GPT-5344H Native Human Glutamic-Pyruvate Transaminase (alanine aminotransferase) Human Liver N/A
Human GPT-26882TH Native Human GPT N/A
Human GPT-2493H Recombinant Human GPT protein, His-tagged E.coli His 146-496 aa
Human GPT-2989H Recombinant Human GPT protein, His-tagged E.coli His 2-496aa
Mouse Gpt-131M Active Recombinant Mouse Gpt protein, His-tagged E.coli His
Mouse Gpt-203M Recombinant Mouse Gpt Protein, His-tagged E.coli His Arg143~Gln417
Mouse Gpt-374M Recombinant Mouse Gpt Protein, His-tagged E.coli N-His Ala2-Ser496
Mouse Gpt-5809M Recombinant Mouse Gpt protein, His-tagged Yeast His 2-496aa
Rat Gpt-294R Recombinant Rat Gpt, His tagged Insect Cell His
Rat Gpt-44R Recombinant Rat Gpt protein, His-tagged E.coli His
Rat ALT-3248R Recombinant Rat ALT, His-tagged E.coli His 496
Rat GPT-2676R Recombinant Rat GPT Protein Mammalian Cell His
Rat Gpt-206R Recombinant Rat Gpt Protein, His-tagged E.coli His Gln203~Leu443
Rat GPT-721RCL Recombinant Rat GPT cell lysate Insect Cell N/A
Rat GPT-2330R Recombinant Rat GPT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GPT-2330R-B Recombinant Rat GPT Protein Pre-coupled Magnetic Beads HEK293
Porcine GPT-189P Active Native Porcine GPT protein Porcine Heart N/A
Rhesus Macaque GPT-1964R Recombinant Rhesus monkey GPT Protein, His-tagged Mammalian Cell His
Rhesus Macaque GPT-1785R-B Recombinant Rhesus Macaque GPT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GPT-1785R Recombinant Rhesus Macaque GPT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig GPT-188S Active Native Swine Glutamate Pyruvate Transaminase Porcine Heart N/A
Pig GPT-204P Recombinant Pig GPT Protein, His/GST-tagged E.coli His/GST Leu16~Ile64
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Gpt Related Articles

Gpt involved in several pathways and played different roles in them. We selected most pathways Gpt participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gpt were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine biosynthesisGLS;GLSA;GOT2B;ARG2;ASL2;GPT2L;NAGS;GPT;GLS2
Alanine, aspartate and glutamate metabolismAGXTA;GAD2;AGXT;GLUD1A;RIMKLA;GLS;NIT2;GOT1;GAD1B
Metabolic pathwaysG6PC2;HK3;PFKL;NME2A;PDHX;AOX2P;GCLM;CYP2C8;PLA2G1B
Carbon metabolismG6PD;MCEE;FBP1B;ALDOB;MDH1;PGD;ackA;PDHA2;OGDH
-Oxocarboxylic acid metabolismACO2;GPT;GOT2;AADAT;GOT2A;ACY1;IDH2;ACO1;GPT2L
Biosynthesis of amino acidsPYCR2;IDH3G;ASL2;PKM;ENO1A;PYCRL;ALDOA;MAT2AL;GPT

Gpt has several biochemical functions, for example, L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gpt itself. We selected most functions Gpt had, and list some proteins which have the same functions with Gpt. You can find most of the proteins on our site.

Function Related Protein
L-alanine:2-oxoglutarate aminotransferase activityGPT2L;GPT;GPT2
pyridoxal phosphate bindingGOT1L1;SHMT1;GAD1B;PDXDC1;CTH;PYGB;PDXK;SDSL;OAT

Gpt has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gpt here. Most of them are supplied by our site. Hope this information will be useful for your research of Gpt.

CDC7; RALA; SASS6

Selleng, S; Selleng, K; et al. Prevalence and clinical implications of anti-PF4/heparin antibodies in intensive care patients: a prospective observational study. JOURNAL OF THROMBOSIS AND THROMBOLYSIS 39:60-67(2015).
Zhang, FS; Chen, WQ; et al. Transcriptional activity comparison of different sites in recombinant Marek's disease virus for the expression of the H9N2 avian influenza virus hemagglutinin gene. JOURNAL OF VIROLOGICAL METHODS 207:138-145(2014).
  • Q&As
  • Reviews

Q&As (5)

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What role does the GPT gene, including GPT1 and GPT2 subtypes, play in glucose and amino acid metabolism, and how is it implicated in cancer-related tumorigenesis? 05/01/2022

The GPT gene, encompassing GPT1 and GPT2, is pivotal in glucose and amino acid metabolism. GPT2 is notably linked to tumorigenesis in various cancers, while the involvement of GPT1 in cancer remains uncertain and requires further exploration.

What role does the GPT gene, encoding cytosolic alanine aminotransaminase 1 (ALT1), play in cellular metabolism and liver function? 04/13/2021

The GPT gene encodes ALT1, a key enzyme in cellular metabolism. ALT1 facilitates the reversible transamination between alanine and 2-oxoglutarate, crucial for glucose and amino acid metabolism. Elevated serum ALT1 levels are commonly used as a biomarker for liver injury caused by drug toxicity, infection, alcohol, and steatosis.

How does the combined SMS and GPT signature affect LSCC patient prognosis, and what factors explain the discrepancy between SMS transcriptional and protein levels? 08/04/2020

SMS protein alone doesn't impact LSCC patient prognosis, but when combined with GPT, it shows significance. Inconsistency between SMS transcriptional and protein levels may stem from various factors, including the involvement of regulatory elements and different post-transcriptional and post-translational modifications.

How does GPT gene expression, assessed in LSCC tissues and cell lines, correlate with SMS and impact overall survival rates in LSCC patients? 01/06/2019

Analysis of LSCC tissues and cell lines revealed an inverse relationship between GPT and SMS expressions, confirmed through qRT-PCR and TCGA data. GPT protein, primarily located in the epithelium, was down-regulated in LSCC tissues.

How does GPT gene expression in tissues like skeletal muscle, kidney, and liver reflect cancer-related metabolic changes? 05/12/2018

GPT gene expression serves as a marker for cancer-induced metabolic reprogramming in tissues, indicating shifts in energy metabolism and biosynthetic processes.

Customer Reviews (3)

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Reviews
11/13/2021

    Fantastic customer support. They genuinely care about the success of our research.

    10/11/2020

      Top-notch protein quality! It's our go-to for reliable and reproducible results.

      04/06/2018

        Very happy with this lab product!

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