gpx1
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  • Official Full Name
  • glutathione peroxidase 1
  • Background
  • Glutathione peroxidase 1 (GPX1) is a cytosolic selenoprotein which reduces hydrogen peroxide to water. GPX1 is the most abundant and ubiquitous among the five GPX isoforms identified so far. It is an important component in the anti-oxidative defense in ce
  • Synonyms
  • GPX1; glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase; GPXD; GSHPX1; MGC14399; MGC88245
Cat.#:GPX1-5307HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX1 Protein, His-tagged
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Cat.#:GPX1-5308HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GPX1 Protein, GST-tagged
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Cat.#:GPX1-1273HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutathione Peroxidase 1, His-tagged
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Cat.#:GPX1-29073THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX1, His-tagged
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Cat.#:GPX1-29074THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX1, His-tagged
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Cat.#:GPX1-7230MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GPX1 Protein
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Cat.#:GPX1-2677RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GPX1 Protein
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Cat.#:GPX1-5202CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GPX1
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Cat.#:GPX1-8429HTag:
Source (Host):ErythrocytesSpecies:Human
Product nameNative Human GPX1
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Cat.#:GPX1-5763HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GPX1 293 Cell Lysate
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Involved Pathway

GPX1 involved in several pathways and played different roles in them. We selected most pathways GPX1 participated on our site, such as Glutathione metabolism, Arachidonic acid metabolism, Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
GSTT2; GSTM3; GGCTB; GCLM; GSTA; RRM2B; GPX4B; GPX1; MGST1.2; G6PDX
Arachidonic acid metabolism
CYP4B1; CYP2C38; AKR1C21; CYP2C55; ALOX8; PTGES3A; CYP2P10; PTGS1; PLA2G2D; CYP4F18
Thyroid hormone synthesis
PRKCG; PRKCA; HSPA5; IYD; CANX; GPX3; ATP1A2; GPX7; GSR; ATP1B4
Amyotrophic lateral sclerosis (ALS)
PRPH; MAPK14; MAPK12; BCL2L1; CASP12; NEFH; RAC1; NEFM; MAP2K6; DAXX
Huntingtons disease
NDUFV2; COX6B1; NDUFS4; NDUFC2-KCTD14; DNAIC2; COX6B2; NDUFV3; DNAL4; NDUFAB1; HIP1

Protein Function

GPX1 has several biochemical functions, for example, SH3 domain binding, glutathione binding, glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX1 itself. We selected most functions GPX1 had, and list some proteins which have the same functions with GPX1. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein EVL; QKI; ELMO1; FMNL3; ILK; LYN; VASPA; DNAJC6; ADAM12; CYBA
Function glutathione binding
Related Protein PTGESL; LANCL1; GSTP2; GSTM7; GSS; LTC4S; GSTM1; PTGES2; GSTM2; MGST1
Function glutathione peroxidase activity
Related Protein GSTZ1; GPX4; LTC4S; GPX6; GPX2; MGST2; GPX5; GPX8; GPX1B; GPX1
Function phospholipid-hydroperoxide glutathione peroxidase activity
Related Protein GPX1; GPX4
Function selenium binding
Related Protein DIO1; SELT; SEP15; SELENBP1; SELENBP2; GPX3; RPH3A; SEPP1; GPX1; DIO2

Interacting Protein

GPX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX1.
glutathione; fumaric acid; MAPK6; SIRT4

GPX1 Related Articles

Guo, X; Yu, Y; et al. Heterologous expression and characterization of human cellular glutathione peroxidase mutants. IUBMB LIFE 66:212-219(2014).
Zemolin, APP; Meinerz, DF; et al. Evidences for a role of glutathione peroxidase 4 (GPx4) in methylmercury induced neurotoxicity in vivo. TOXICOLOGY 302:60-67(2012).