GPX1 Protein, glutathione peroxidase 1

GPX1

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GPX1

Official Full Name glutathione peroxidase 1
Background Glutathione peroxidase 1 (GPX1) is a cytosolic selenoprotein which reduces hydrogen peroxide to water. GPX1 is the most abundant and ubiquitous among the five GPX isoforms identified so far. It is an important component in the anti-oxidative defense in ce
Synonyms GPX1; glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase; GPXD; GSHPX1; MGC14399; MGC88245
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Erythrocytes
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GPX1-1273H Recombinant Human Glutathione Peroxidase 1, His-tagged Human His
    Human GPX1-29073TH Recombinant Human GPX1, His-tagged E.coli His
    Human GPX1-29074TH Recombinant Human GPX1, His-tagged E.coli His
    Human GPX1-5307H Recombinant Human GPX1 Protein, His-tagged E.coli His
    Human GPX1-5308H Recombinant Human GPX1 Protein, GST-tagged Wheat Germ GST
    Human GPX1-5763HCL Recombinant Human GPX1 293 Cell Lysate HEK293 N/A
    Human GPX1-8429H Native Human GPX1 Erythrocytes N/A
    Mouse GPX1-7230M Recombinant Mouse GPX1 Protein Mammalian Cell His
    Rat GPX1-2677R Recombinant Rat GPX1 Protein Mammalian Cell His
    Chicken GPX1-5202C Recombinant Chicken GPX1 Mammalian Cell His

    GPX1 involved in several pathways and played different roles in them. We selected most pathways GPX1 participated on our site, such as Glutathione metabolism, Arachidonic acid metabolism, Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glutathione metabolism GSS; GSTT2B; GSTK1; LAP3; RRM1; GSTA1; GSTA2; GPX4A; MGST1.1; GPX7
    Arachidonic acid metabolism PTGES3; CYP2N13; PLA2G4D; CYP2C50; GPX7; ALOX5AP; PLA2G2E; ALOX5A; GPX8; CYP2P8
    Thyroid hormone synthesis PRKACA; IYD; DUOXA2; CREB3L1; GPX5; CREB3L2; PLCB2; PAX8; GNAQ; SLC5A5
    Amyotrophic lateral sclerosis (ALS) GRIN2C; NEFM; TNFRSF1A; PRPH; NEFL; TOMM40; NOS1; APAF1; MAPK14; Casp3
    Huntingtons disease POLR2G; mt-Atp8; VDAC2; DCTN4; NDUFA5; PPARGC1A; COX7A2L; NDUFS1; HDAC2; DCTN1

    GPX1 has several biochemical functions, for example, SH3 domain binding, glutathione binding, glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX1 itself. We selected most functions GPX1 had, and list some proteins which have the same functions with GPX1. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding SH3BP2; FUT8; ARHGAP31; WAS; ZFP106; CBL; DNAJC6; GPX1; LYN; PLSCR3
    glutathione binding GPX1; GSS; LANCL1; GSTM1; PTGES2; LTC4S; GSTM7; PTGES; GSTM3; GSTM4
    glutathione peroxidase activity GPX3; GSTT1; GPX4B; MGST1; GPX5; GPX4; MGST2; GPX1A; CLIC2; GSTZ1
    phospholipid-hydroperoxide glutathione peroxidase activity GPX1; GPX4
    selenium binding SELT; DIO2; SELENBP1; GPX3; RPH3A; SELENBP2; DIO1; GPX1; SEP15; SEPP1

    GPX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX1.

    glutathione; fumaric acid; MAPK6; SIRT4

    Guo, X; Yu, Y; et al. Heterologous expression and characterization of human cellular glutathione peroxidase mutants. IUBMB LIFE 66:212-219(2014).
    Zemolin, APP; Meinerz, DF; et al. Evidences for a role of glutathione peroxidase 4 (GPx4) in methylmercury induced neurotoxicity in vivo. TOXICOLOGY 302:60-67(2012).

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