grb2
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  • Official Full Name
  • growth factor receptor-bound protein 2
  • Background
  • The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
Cat.#:GRB2-5038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST-tagged
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Cat.#:GRB2-5248HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST/His-tagged
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Cat.#:GRB2-127HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 protein, T7/His-tagged
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Cat.#:GRB2-13520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, GST-tagged
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Cat.#:GRB2-28345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, His-tagged
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Cat.#:GRB2-28483THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2
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Cat.#:GRB2-435HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GRB2 protein, His-tagged
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Cat.#:GRB2-4847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
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Cat.#:GRB2-500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-bound Protein 2, His-tagged
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Cat.#:GRB2-2686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB2 Protein
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Cat.#:GRB2-565CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GRB2 Protein, His-tagged
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Cat.#:GRB2-5981CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB2
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Cat.#:GRB2-5755HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GRB2 293 Cell Lysate
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Involved Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF10A; STMN1; TGFBR1A; TP53; PDGFRA; AKT3A; GNG12A; FGF7; CACNA2D4; FGF18
ErbB signaling pathway
CAMK2A; SHC1; CAMK2D2; ERBB3A; PAK2; PIK3CA; ABL1; PAK1; PRKCB; STAT5A
Ras signaling pathway
MLLT4; Pdgfa&Pdgfb; INS2; PLA2G4C; FGF4; IKBKB; PLA1A; CALML5; RASGRF2; ZAP70
Chemokine signaling pathway
CCL14; CXCR3; CXCR1; BCAR1; GNG10; PREX1; GNAI2; GNG8; CCL17; PIK3CD
FoxO signaling pathway
CCNB2; IRS2; ATG12; SOS1; PIK3R2; SGK2; FOXO3A; GADD45G; MAPK14B; INSRB
Phospholipase D signaling pathway
PDGFB; GNAS; GRM8; AVP; PIK3CA; CYTH2; PIP5K1A; Pdgfa&Pdgfb; AVPR1A; PIK3CG
PIK-Akt signaling pathway
MLST8; VEGFA; FGF4; SGK1; F2R; RBL2; ANGPT4; IL4R; ITGA7; GSK3B
Dorso-ventral axis formation
KRAS; PIWIL4; GRB2; MAPK1; MAP2K1; ETV7; PIWIL2; ETS1; CPEB3; CPEB1
Osteoclast differentiation
NFKB1; FOSL2; MAP2K7; LILRA1; GRB2; TGFB1; FCGR1; CALCR; TYROBP; PPP3R1
Focal adhesion
PDPK1B; SRMS; ACTN1; CCND1; ROCK2B; HRASA; COL6A3; PRKCBB; ACTB1; ACTN3B
Gap junction
ADCY1A; PDGFAA; LPAR1; GJA1; PRKCBA; PRKACBA; TUBA4A; HRAS; PDGFRB; HTR2C
Signaling pathways regulating pluripotency of stem cells
KLF4; GSK3B; FZD2; ID2; WNT9A; INHBB; MAPK11; FZD8; FZD3; MAPK13
Jak-STAT signaling pathway
PRLRA; Ifnl2; SOCS5; IL23; IL20; AKT2L; GRB2A; IL12RB2; CISHB; AOX1
Natural killer cell mediated cytotoxicity
PLCG2; IFNB1; PIK3R5; PPP3CC; NCR3; PTPN11; HLA-A; RAET1G; SYK; SH2D1B
T cell receptor signaling pathway
CD247; IKBKG; PPP3R1; LCP2; CBLC; MAPK3; NFKBIE; OXSR1A; ICOS; NRAS
B cell receptor signaling pathway
CD79B; ARPC4; MAP4K1; LIME1; CSK; ITK; PDK2; RAC1; PLCG2; IFITM1
Fc epsilon RI signaling pathway
PLCG2; LAT; FYN; MAPK1; MAPK12; PIK3CD; KRAS; MAP2K4; TNF; IL5
Neurotrophin signaling pathway
NGF; KIDINS220; RPS6KA3; MAPK10; RPS6KA5; TP73; RAP1B; GAB1; MAP2K7; FOXO3
Insulin signaling pathway
PPP1CAB; FLOT2A; LIPE; SHC3; PIK3CG; PHKB; MAPK8; TRIP10A; PPP1R3CB; AKT3A
GnRH signaling pathway
PLCB2; MAP3K2; MAP2K7; RAF1B; MMP14A; GRB2B; MAPK12; CALM1; NRAS; CACNA1DA
Estrogen signaling pathway
KCNJ6; SRC; AKT2; PIK3R3; PIK3CD; OPRM1; CALM1; HSP90AB1; CALML3; CALM4
Prolactin signaling pathway
INS1; SLC2A2; KRAS; TH; GRB2; MAPK13; ESR2; PRL; SHC3; AKT1
Alcoholism
H2AFY; MAP2K1; HIST1H2BO; CRH; H2AFY2; HIST1H2AP; GNB1; HIST3H2BB-PS; HIST1H2AE; HIST2H3C
Hepatitis C
NRAS; SCARB1; OCLN; OAS2; CLDN3; PIK3R5; OSTN; CD81; STAT1; TRADD
Hepatitis B
CASP10; CCNA1; MAPK10; IFN-a; STAT5B; MAP2K4; STAT3; GRB2; Ifna11; EP300
Pathways in cancer
NRAS; GNAI2; MAP2K1; CUL2; TRAF4; BIRC2; FGF17; FGFR3; ARHGEF1; WNT2
Viral carcinogenesis
HIST1H4A; RELA; RAC1; TBPL2; MAPK3; HDAC3; REL; HIST1H2BL; HIST1H2BQ; CCNA1
Proteoglycans in cancer
PRKCA; IGF1R; PAK1; ARHGEF1; PPP1R12B; CAMK2D; NANOG; Casp3; PPP1CC; CD63
MicroRNAs in cancer
PDGFB; RPTOR; APC2; HMGA2; GLS2; PTGS2; MDM4; RPS6KA5; RHOA; TP53
Renal cell carcinoma
TGFB2; ARAF; GRB2; PDGFB; RBX1; VEGFA; RAP1B; PAK2; EP300; PIK3CD
Endometrial cancer
PIK3R5; CTNNA3; AKT1; CDH1; AXIN2; MAPK1; FOXO3; CCND1; TCF7L2; PDPK1
Glioma
HRAS; MTOR; MAPK3; CALM4; AKT1; IGF1; PIK3CD; SHC2; GRB2; PLCG2
Prostate cancer
Ar; NOXA1; PIK3R2; PDPK1; BRAF; CREB3L3; MAP2K2; CPN1; IKBKB; FOXA1
Chronic myeloid leukemia
IKBKG; CBLB; RELA; PIK3R3; SHC3; TGFBR2; CCND1; HRAS; NFKBIA; ABL1
Acute myeloid leukemia
RPS6KB1; IKBKG; PIM2; STAT3; PIK3CD; KRAS; CCND1; PIM1; PIK3R3; TCF7
Non-small cell lung cancer
PIK3R2; MAP2K1; BAD; CCND1; PDPK1; STK4; PRKCA; TRP53; KRAS; ALK
Choline metabolism in cancer
PRKCA; WAS; RHEB; SLC22A1; PDGFB; WASF1; GRB2; SLC22A3; PIP5K1A; MAPK8

Protein Function

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein BCAR1; CRB3; SH3BGRL2; SKAP1; DOCK4; ABL1; PAK3; SH3BP1; SHANK3; TOM1L1
Function SH3/SH2 adaptor activity
Related Protein SH2D3C; SH2B2; GAB1; CRK; FCRL2; SH2D3A; SH3BGRL; SH2D1A; TOB1; ITSN2
Function ephrin receptor binding
Related Protein EFNA1; NTRK1; SDCBP; SRC; FYN; EPHA4; PTPN1; CHN1; NTRK3; SIPA1L1
Function epidermal growth factor receptor binding
Related Protein SOCS5; ARF4; EFEMP1; EREG; AREG; VAV2; SNX2; CBLC; AGR2; ATXN2
Function identical protein binding
Related Protein TRA@; PFKM; KCTD17; GRB7; MRFAP1L1; BNIP2; CD28; RCAN1; DRD4; LEPR
Function insulin receptor substrate binding
Related Protein PIK3CB; INSRA; INSRR; IGF1R; PIK3CA; PIK3R1; INSR; IGF1RA; IGF1RB; INSRB
Function neurotrophin TRKA receptor binding
Related Protein EFNA5; PLCG1; FRS2; NGFR; PIK3R1; SHC1; GRB2
Function phosphotyrosine binding
Related Protein PTPN3; GRB2; ACP2; ZAP70; LDLRAP1; CBLC; STAP1; CBLB; SAMSN1; SHC1
Function poly(A) RNA binding
Related Protein HIST1H1E; QK; CIRBP; SORBS2; GTF2F1; UBC; LRPPRC; RPS27A; UNK; DCAF13
Function protein binding
Related Protein CD247; KCNJ15; MRPL51; ACTL8; AF251705; RTN4RL1B; PRIMPOL; FAAH; GABBR2; SUGP1
Function protein kinase binding
Related Protein CD4; SHC1; MVP; CCNT2A; PDGFRB; ZC3HC1; SHC3; CDKN2D; TPCN2; MEF2A
Function protein phosphatase binding
Related Protein IRS2; LCK; MET; CTNNB1; EIF2AK3; TRAF2; VRK3; CDC27; FGF19; CSF1R

Interacting Protein

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR

GRB2 Related Articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).