grb2
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  • Official Full Name
  • growth factor receptor-bound protein 2
  • Background
  • The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
Cat.#:GRB2-5038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST-tagged
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Cat.#:GRB2-5248HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST/His-tagged
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Cat.#:GRB2-127HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 protein, T7/His-tagged
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Cat.#:GRB2-13520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, GST-tagged
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Cat.#:GRB2-28345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, His-tagged
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Cat.#:GRB2-28483THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2
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Cat.#:GRB2-435HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GRB2 protein, His-tagged
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Cat.#:GRB2-4847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
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Cat.#:GRB2-500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-bound Protein 2, His-tagged
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Cat.#:GRB2-2686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB2 Protein
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Cat.#:GRB2-565CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GRB2 Protein, His-tagged
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Cat.#:GRB2-5981CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB2
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Cat.#:GRB2-5755HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB2 293 Cell Lysate
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Involved Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RPS6KA3; MAP3K3; FGF7; AKT2; Casp3; CACNB3A; TAOK3; PTPN7; MAP4K1; PPP3CB
ErbB signaling pathway
RPS6KB2; PIK3R2; CDKN1BA; PAK2B; GRB2A; MAPK1; PRKCA; MAPK8B; CAMK2G; KRAS
Ras signaling pathway
MAPK8; PIK3CB; PAK2; NRAS; RASSF5; FGF7; AKT1; RASAL2; PLA2G6; PLA2G3
Chemokine signaling pathway
SHC3; PREX1; CXCR3; CCL18; CCR7; GNG2; AKT1; CXCR1; CXCL12; GNG11
FoxO signaling pathway
FOXG1; PRKAB2; PTENB; SGK3; FOXO1; MAPK12B; GADD45AB; AGAP2; BNIP4; CDKN2D
Phospholipase D signaling pathway
RAF1; MRAS; PLA2G4A; AVP; PIK3CB; PIP5K1B; DGKE; MAPK3; RHOA; PDGFA
PIK-Akt signaling pathway
FGFR4; SPP1; RXRA; TNXB; KIT; SGK1; PKN1; TLR4; PHLPP1; FGF20
Dorso-ventral axis formation
EGFRA; NOTCH1; MAP2K1; MAPK1; SOS1; GRB2; NOTCH1B; KRAS; ETV6; CPEB1A
Osteoclast differentiation
PPP3R2; ITGB3; MAPK9; GAB2; FCGR1A; BTK; cgr2b; FOSB; TYROBP; FOSL2
Focal adhesion
MYLK3; PPP1CC; IGF1RA; FYNB; MYLPFA; Itga10&Itgb1; ACTN3B; ACTB; CAPN2A; FLT4
Gap junction
PRKACAB; PDGFAA; TUBA8L2; RAF1B; EGFRA; DRD1B; Pdgfa&Pdgfb; PDGFAB; CX35B; ITPR1
Signaling pathways regulating pluripotency of stem cells
PIK3R3; ACVR1C; FGF2; PCGF3; SMAD9; SMAD4; MAPK13; Fzd4; WNT11; PAX6
Jak-STAT signaling pathway
CTF1; IL7R; GM2002; AKT2L; PIK3CG; CNTFR; IL12B; IL15; SOCS5B; RAF1B
Natural killer cell mediated cytotoxicity
HRAS; NCR3; IFNG; VAV2; KRAS; PAK1; Casp3; KIR2DS2; PTPN6; PPP3CC
T cell receptor signaling pathway
PIK3CB; LAT; DLG1; PAK7; PPP3R1; MAP2K7; MAPK12; NCK2; CD8A; CD8B
B cell receptor signaling pathway
CMTM3; FCGR2B; PIK3CB; MAPK3; GRB2; PTPN6; CDK2; Cd79a, Cd79b; SOS1; CR2
Fc epsilon RI signaling pathway
MAPK11; FCER1A; MS4A2; PLA2G4A; MAPK10; PLA2G4C; MAPK13; RAC3; MAP2K7; PIK3R2
Neurotrophin signaling pathway
GRB2; RELA; PIK3CG; RHOA; SHC3; Fasl; ABL1; ATF4; RPS6KA5; RPS6KA1
Insulin signaling pathway
MKNK2; RAF1; TSC1A; SOCS3; KRAS; MAPK8B; RPS6; FLOT1A; PIK3R5; GSK3AA
GnRH signaling pathway
EGFRA; PLA2G4AA; CALM2; CAMK2G1; CALM3B; HRASA; PRKACBB; CACNA1DA; PLCB1; MAP2K4B
Estrogen signaling pathway
HSP90B1; SRC; GNAS; PLCB4; PIK3R5; GABBR2; HSPA1B; SHC4; RAF1; GRB2
Prolactin signaling pathway
MAPK9; TNFSF11; SRC; SOCS3; PIK3CA; ELF5; STAT1; CSN2; MAPK8; NFKB1
Alcoholism
GM14476; HIST2H3C1; GNB2; HIST1H2AD; GNG4; HIST1H4F; MAP2K1; PPP1CB; DRD1; GNAS
Hepatitis C
CLDN1; CLDN10; IFNA7; NRAS; CLDN5; PDPK1; STAT1; IFNAR2; Ifna11; CD81
Hepatitis B
CASP9; NFATC1; IL6; DDB2; BAX; TNF; MAP3K1; STAT4; Ifna15; BIRC5
Pathways in cancer
PTGER3; FLT3LG; STAT5B; RASGRP3; WNT9B; RARB; FGF12; GLI2; WNT6; Fzd4
Viral carcinogenesis
TP53; TBP; SNW1; HIST1H2BN; IL6ST; TRAF3; REL; GTF2E1; GTF2H1; GTF2A1
Proteoglycans in cancer
FN1; PPP1CC; RAF1; PAK1; IGF2; PTCH1; WNT9A; TWIST1; FZD6; AKT1
MicroRNAs in cancer
TIMP3; ABCB1; TNXB; GLS; PRKCE; MDM4; TNR; TTC6; CCND1; SHC1
Renal cell carcinoma
BRAF; PAK3; NRAS; CUL2; RAP1B; AKT1; TGFB3; AHA-1; PIK3CD; FH
Endometrial cancer
TP53; AXIN2; LEF1; AKT2; ERBB2; APC; PDPK1; PIK3CA; CCND1; TCF7
Glioma
PIK3R2; CALML5; PRKCA; CAMK2D; PIK3CD; AKT1; PDGFB; PIK3R5; PLCG1; MAPK3
Prostate cancer
BAD; CASP9; TGFA; SRD5A2; PIK3CB; Pdgfa&Pdgfb; PIK3R2; NKX3; ERBB2; GSTP1
Chronic myeloid leukemia
MAPK3; CBLB; CBL; MAP2K2; PIK3R1; TGFBR1; PIK3R5; GAB2; MAPK1; PIK3CB
Acute myeloid leukemia
EIF4EBP1; NRAS; MAPK1; RPS6KB1; PIK3R5; TCF7L2; RELA; MYC; PML; RARA
Non-small cell lung cancer
CCND1; NRAS; TRP53; RXRA; PIK3R5; RXRB; MAP2K2; HRAS; PIK3CA; PDPK1
Choline metabolism in cancer
WASF3; RPS6KB1; SP1; DGKB; SLC22A3; PPAP2B; PIP5K1B; FOS; Pdgfa&Pdgfb; MAPK1

Protein Function

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein NCF1; QKI; ARHGAP6; ARHGAP17; GJA1; CCDC6; CBLC; WAS; ITGB1BP2; LRP2
Function SH3/SH2 adaptor activity
Related Protein SH2D2A; CRK; PAG1; CHN1; CNTNAP1; SKAP2; GRB2; SH2D3A; SHB; STAP1
Function ephrin receptor binding
Related Protein EFNA1; NTRK3; PIK3CG; EFNB2; EFNA1A; CDK5; SRC; EFNA2A; NTRK1; GRB2
Function epidermal growth factor receptor binding
Related Protein CBLC; EREG; LINGO1B; AREG; ERBB4; YES1; VAV2; SNX4; HBEGFB; HBEGFA
Function identical protein binding
Related Protein ESR1; ERN1; STAC3; SNCA; CRYAA; CLDN8; CNTN2; IK; CSK; CHMP4B
Function insulin receptor substrate binding
Related Protein PIK3CA; PRKCZ; PRKCD; IGF1R; GRB2; JAK2; PTPN11; PIK3CB; INSRB; PIK3R1
Function neurotrophin TRKA receptor binding
Related Protein NGFR; EFNA5; PIK3R1; PLCG1; FRS2; SHC1; GRB2
Function phosphotyrosine binding
Related Protein SAMSN1; MAPK3; ACP2; PTPN3; GRB2; CBL; SHC1; LDLRAP1; CBLC; MAPK1
Function poly(A) RNA binding
Related Protein TRMT2A; MRPL3; HSP90AB1; TRMT1L; MATR3; CCT6A; BTF3; ASCC3; SAMD4A; CDC40
Function protein binding
Related Protein APOBEC2A; HINT2; LIN37; LINGO1B; PRMT2; KRT33B; PIDD1; PITPNM1; TEAD1; LRP6
Function protein kinase binding
Related Protein FGFR1OP; LATS1; GATA4; RPS6KA3; CDK5; PTPRR; IRS2; PARP1; RACGAP1; NGFRAP1
Function protein phosphatase binding
Related Protein STAT3; TRP53; MAP3K5; CDH2; Itga10&Itgb1; ANAPC5; ITGA1; GRB2; HSP90B1; RPA2

Interacting Protein

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR

GRB2 Related Articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).