grb2
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  • Official Full Name
  • growth factor receptor-bound protein 2
  • Background
  • The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
Cat.#:GRB2-5038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST-tagged
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Cat.#:GRB2-5248HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST/His-tagged
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Cat.#:GRB2-127HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 protein, T7/His-tagged
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Cat.#:GRB2-13520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, GST-tagged
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Cat.#:GRB2-28345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, His-tagged
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Cat.#:GRB2-28483THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2
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Cat.#:GRB2-435HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GRB2 protein, His-tagged
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Cat.#:GRB2-4847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
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Cat.#:GRB2-500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-bound Protein 2, His-tagged
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Cat.#:GRB2-2686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB2 Protein
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Cat.#:GRB2-565CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GRB2 Protein, His-tagged
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Cat.#:GRB2-5981CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB2
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Cat.#:GRB2-5755HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB2 293 Cell Lysate
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Involved Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FLNB; PRKACBB; FGF21; MEF2C; MAP2K6; NFATC3; MAPK12A; NFKB2; ATF4B1; PPM1NB
ErbB signaling pathway
PIK3R1; ELK1; CAMK2G; BRAF; NRG2B; AKT2L; AKT1; ABL1; MYCB; STAT5B
Ras signaling pathway
PIK3R5; MAPK3; GNB1; NF1; SHC4; GAB1; RRAS; PLD2; PLA2G12B; PLA2G3
Chemokine signaling pathway
PIK3R1; STAT2; CCL6; GNG5; PRKCD; PLCB2; GRK4; ELMO1; JAK2; CCL17
FoxO signaling pathway
STAT3; NRAS; G6PC; NLK1; CDKN1BB; GADD45G; G6PC2; PCK2; PLK2B; INS2
Phospholipase D signaling pathway
PRKCA; Kitl; AKT2; PLA2G4C; ARF6; AVP; MRAS; GRM7; LPAR5; MAP2K1
PIK-Akt signaling pathway
PDGFB; PRL; NRAS; RPS6KB2; VEGFB; AKT2; THBS4; TNC; BCL2; AKT1
Dorso-ventral axis formation
KRAS; SPIRE1A; PPP1R2P9; CPEB2; CPEB3; PIWIL2; GRB2A; EGFRA; ETS1; MAPK3
Osteoclast differentiation
MAPK13; PIK3CB; MAP3K7; FCGR2C; SFPI1; IL1R1; PIK3CD; STAT2; NCF4; TNFRSF1A
Focal adhesion
TLN2A; LAMB3; BRAF; VTN; FIGF; ACTN2B; SHC4; PTK2AB; MYL12.1; ITGB3B
Gap junction
PRKACAA; MAPK7; ITPR1; PRKACAB; ADCY1A; TUBA8L2; TUBB6; TUBA3D; DRD1A; TUBA1C
Signaling pathways regulating pluripotency of stem cells
BMPR1B; FZD7; FZD6; IL6ST; PCGF2; WNT5A; WNT8A; BMI1; HRAS; BMP4
Jak-STAT signaling pathway
SOCS6; THPO; PIK3R3A; IL29; IL-15RA; CSF3; PIM1; FHL1B; HRAS; CRFB2
Natural killer cell mediated cytotoxicity
FCGR3B; IFNA8; Raet1a; FCGR3; LCK; IFNA14; PPP3CB; ULBP2; ITGB2L; PTK2B
T cell receptor signaling pathway
ZAP70; NFATC1; PIK3R1; PPP3CB; PAK3; KRAS; MAPK1; MAP3K7; NCK2; AKT1
B cell receptor signaling pathway
ARPC4; MAP2K1; RASGRP3; IGHM; NFKB1; CDK6; CDK4; GSK3AB; MAP2K2; ARPC3
Fc epsilon RI signaling pathway
PLCG1; RAF1; FYN; GRB2; NRAS; PIK3R5; IL5; PIK3CG; PIK3CD; SYK
Neurotrophin signaling pathway
RHOA; PIK3CA; NTRK2; PIK3CB; CALM3; MAPK1; IKBKB; NRAS; SORT1; NGFRAP1
Insulin signaling pathway
ACACB; PRKAR1AB; LIPE; PRKACA; AKT2L; PTPRF; INS; PYGM; FLOT2; PPP1CC
GnRH signaling pathway
ELK1; PRKACBA; SOS1; PLD2; GNRHR; RAF1B; MAP3K3; PLA2G4D; GNRHR4; MMP14B
Estrogen signaling pathway
PLCB2; HSPA8; OPRM1; PIK3CA; SHC1; KCNJ3; SP1; KRAS; GPR30; ITPR3
Prolactin signaling pathway
CCND1; STAT5A; SIRPA; HRAS; KRAS; GRB2; PIK3R1; PIK3CB; SRC; MAPK12
Alcoholism
H2AFX; KRAS; CREB3L1; ATF4; PPP1CA; HIST1H2AD; GNG8; GRIN2D; GRIN2A; HDAC9
Hepatitis C
TP53; MAPK13; MAPK9; HRAS; IFNA8; IFNA14; MAPK12; IFNA21; BAD; IFNAR2
Hepatitis B
DDX58; GRB2; SRC; CCNA2; CCNE2; STAT5B; TLR3; IFNA2; STAT6; Casp3
Pathways in cancer
RARB; FGF9; LAMB2; BIRC8; LAMA5; WNT10B; DAPK3; STK4; CCNE1; BCR
Viral carcinogenesis
CREB3L2; ACTN2; HIST1H4G; HDAC3; MDM2; HIST1H4N; RANBP1; HLA-E; HDAC11; CREB3L1
Proteoglycans in cancer
PPP1CA; RRAS2; MRAS; RRAS; ACTG1; TWIST1; TP53; CTTN; WNT5A; SDC4
MicroRNAs in cancer
DNMT3A; RASSF1; WNT3; FGFR3; VIM; IGF2BP1; CDC25A; EZR; SLC45A3; MMP9
Renal cell carcinoma
PAK3; PAK1; HIF1A; MAP2K2; AKT1; PIK3R1; FH; VEGFA; TGFA; BRAF
Endometrial cancer
AKT2; RAF1; PIK3R5; KRAS; PIK3CG; PTEN; ILK; MAPK3; TRP53; AXIN2
Glioma
CAMK2B; IGF1; PIK3R1; CAMK2D; GRB2; AKT1; CAMK2A; PDGFA; MDM2; TP53
Prostate cancer
CREB3L2; PDGFA; INS; SMARCA4; CCNE1; FGFR2; TGFA; PIK3R3; CREB3L3; NDRG1
Chronic myeloid leukemia
BRAF; MAPK1; RUNX1; MAP2K1; IKBKB; SMAD3; TGFBR1; MECOM; CBL; CRKL
Acute myeloid leukemia
SOS1; BAD; PIK3R2; PIK3CA; ZBTB16; JUP; PIK3R3; MTOR; RPS6KB1; KIT
Non-small cell lung cancer
MAPK3; PIK3R1; EML4; RASSF1; ALK; BRAF; PIK3CG; PRKCB; RASSF5; PIK3R3
Choline metabolism in cancer
MAPK9; PIK3CB; PDGFB; WASF2; DGKD; DGKZ; CHKA; MTOR; PIK3R2; LYPLA1

Protein Function

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein FMNL3; ITM2B; MYPN; USP8; EFS; GJA1; NCF1; QKI2; CBL; CCDC6
Function SH3/SH2 adaptor activity
Related Protein GRB14; BLNK; SH2D2A; ITSN2; SH2B2; SH2D3A; CRK; SKAP2; NCK2; SH3BGRL
Function ephrin receptor binding
Related Protein SDCBP; EFNB2B; EFNB2; EFNA1; EFNA4; NTRK3; EFNB3; SHC1; EFNA5; ANKS1B
Function epidermal growth factor receptor binding
Related Protein TNK2; CBLC; FAM83B; SNX1; EREG; EPGN; VAV3; Fert2; SOCS5; LINGO1B
Function identical protein binding
Related Protein CLDND; CD74; TPRGL; DVL1; DES; C1S; NUDT16; CALCA; FBP1; UBQLN1
Function insulin receptor substrate binding
Related Protein PTPN11; IGF1RB; INSR; INSRR; PIK3CB; IGF1R; INSRA; PRKCZ; PRKCD; INSRB
Function neurotrophin TRKA receptor binding
Related Protein EFNA5; PLCG1; PIK3R1; GRB2; SHC1; FRS2; NGFR
Function phosphotyrosine binding
Related Protein PTPN3; LDLRAP1; SAMSN1; ZAP70; STAP1; CBLB; CBLC; CBL; ACP2; GRB2
Function poly(A) RNA binding
Related Protein CSRP1; RPL36; UBAP2; PSIP1; PARP1; RTCD1; EIF1AX; HMGB2; GNB2L1; EIF2AK2
Function protein binding
Related Protein IRAK4; ELK3; RAB5C; FCGR1A; RPL19; METTL13; EP400; KISS1; FLRT3; PSRC1
Function protein kinase binding
Related Protein PRKAB1; XBP1; CD36; AKAP7; ELP2; GOLGA2; NSF; RPS6; RAD9A; JAK2
Function protein phosphatase binding
Related Protein RPA2; IRS2; JAK1; HSP90B1; PPP1R3G; STAT6; LCK; CSF1R; ANAPC5; JUP

Interacting Protein

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR

GRB2 Related Articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).