grb2
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  • Official Full Name
  • growth factor receptor-bound protein 2
  • Background
  • The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
Cat.#:GRB2-5038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST-tagged
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Cat.#:GRB2-5248HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST/His-tagged
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Cat.#:GRB2-127HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 protein, T7/His-tagged
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Cat.#:GRB2-13520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, GST-tagged
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Cat.#:GRB2-28345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, His-tagged
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Cat.#:GRB2-28483THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2
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Cat.#:GRB2-435HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GRB2 protein, His-tagged
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Cat.#:GRB2-4847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
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Cat.#:GRB2-500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-bound Protein 2, His-tagged
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Cat.#:GRB2-2686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB2 Protein
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Cat.#:GRB2-565CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GRB2 Protein, His-tagged
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Cat.#:GRB2-5981CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB2
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Cat.#:GRB2-5755HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB2 293 Cell Lysate
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Involved Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GRB2A; MAP2K5; JUND; RELA; MEF2CA; NTRK2B; FLNA; HSC70; PDGFA; MAPK3
ErbB signaling pathway
ABL1; PRKCB; HRASB; NRG2; PIK3CA; PIK3R1; MAP2K2; RAF1B; ELK1; MAP2K1
Ras signaling pathway
PTPN11; RAC2; FGF13; PLA2G2F; SHC2; RAB5C; PLA2G12B; LOC608458; FGF9; PIK3CB
Chemokine signaling pathway
GNGT2; PTK2; CRK; GSK3A; RAC2; CXCR4; SHC3; PRKCD; FGR; Ccl27a
FoxO signaling pathway
STK4; PIK3CD; INSR; CCNB3; FOXO3; CDKN2B; BNIP3; ATG12; BCL6; MAPK12B
Phospholipase D signaling pathway
TSC1; PTGFR; GRM4; HRAS; PIK3CD; NRAS; ARF6; AVPR2; PIP5K1A; LPAR4
PIK-Akt signaling pathway
INSR; ITGB7; GH2; IFNAR1; KIT; BAD; IL6; GNG7; PDGFRB; NR4A1
Dorso-ventral axis formation
GRB2A; ETV7; NOTCH1; ETV6; GRB2; EGFRA; NOTCH2; SPIRE2; PIWIL1; CPEB3
Osteoclast differentiation
PPP3CB; LILRA1; OSCAR; MAPK3; TGFBR1; SOCS1; MAPK12; SFPI1; PPP3CA; FCGR3A
Focal adhesion
PAK2; TNW; ITGA9; MAPK6; MET; COL27A1A; CAV2; ACTN4; THBS1; MYLK2
Gap junction
RAF1A; PRKACBB; GUCY1A3; DRD1A; DRD1B; MAP2K2A; PDGFAB; TUBA3B; EGFRA; GNAIA
Signaling pathways regulating pluripotency of stem cells
PIK3R1; SKIL; PAX6; INHBE; PCGF5; FZD8; ONECUT1; MAP2K1; PIK3CB; RAF1
Jak-STAT signaling pathway
NT5C3; IL11; JAK2A; TSLP; SOCS1; IL2RGA; LIFRA; CTF1; IL22RA2; IL12A
Natural killer cell mediated cytotoxicity
RAC2; PPP3R2; CD244; LCK; RAET1L; IFNA12; ICAM2; BRAF; MAP2K2; Raet1c
T cell receptor signaling pathway
NCK2; RAF1; MAPK12; NCK1; CD40LG; AKT1; NFKBIE; DEF6A; MAP3K14; CD8B1
B cell receptor signaling pathway
CD79A; PPP3CC; FOS; RASGRP3; RAC3; PPP3R2; RAC2; PIK3CG; NFATC3; BLK
Fc epsilon RI signaling pathway
PIK3R2; LAT; RAC2; VAV2; PIK3CD; MAPK12; IL3; BTK; MS4A2; RAF1
Neurotrophin signaling pathway
BRAF; MAP3K5; GAB1; PLCG2; RPS6KA5; PLCG1; RAC1; RPS6KA1; ZNF274; CAMK2G
Insulin signaling pathway
PIK3R1; CALM3; SLC2A4; MAPK3; PDE3B; FBP2; MAP2K1; PRKAB2; ACACB; MAPK10
GnRH signaling pathway
GNA15.4; GNAQ; SRC; MAP2K3; FSHB; PRKCDA; GNAS; MAPK7; ADCY2B; RAF1B
Estrogen signaling pathway
HRAS; PRKACA; HSPA1L; PIK3CD; SHC3; PIK3CB; Adcy4; ATF4; RAF1; NRAS
Prolactin signaling pathway
ESR1; LHB; PIK3R2; SOS1; STAT1; MAPK13; PRP2; NEK3; SLC2A2; SIRPA
Alcoholism
CREB3L3; H2AFB1; HIST1H2BD; HIST1H2BN; HRAS; HIST1H4F; SLC18A2; CAMKK1; CALML3; CAMK4
Hepatitis C
HRAS; CLDN18; GRB2; RNASEL; BRAF; CLDN8; IFNA1; Ifna15; PIK3R3; PIK3R1
Hepatitis B
STAT1; IFNA12; HRAS; IFN-a; Casp3; CCND1; NFATC3; SRC; PIK3R2; HBXIP
Pathways in cancer
VEGFB; VHL; TCEB1; HSP90AB1; RXRA; AXIN1; STAT5B; CTBP2; MITF; APC2
Viral carcinogenesis
HLA-C; PIK3R2; GTF2H2; EGR3; VAC14; HIST1H2BN; CDC20; GTF2H2C; HDAC11; IRF7
Proteoglycans in cancer
VTN; HCLS1; PLAU; NANOG; PLCG2; PRKCA; CAMK2D; PPP1CC; TIMP3; CAMK2G
MicroRNAs in cancer
SHC1; PLCG1; THBS1; FZD3; ZFPM2; FGFR3; SPRY2; IGF2BP1; EZR; ROCK1
Renal cell carcinoma
RAF1; FH1; FH; PIK3CB; PAK1; TGFA; PIK3R1; HRAS; RAPGEF1; EPAS1
Endometrial cancer
AKT2; BAD; MAPK1; ILK; ELK1; APC2; PDPK1; AKT1; AXIN2; PIK3R5
Glioma
PIK3R5; SHC3; Pdgfa&Pdgfb; PIK3R3; AKT2; PIK3CB; IGF1R; PDGFRB; SHC1; SHC4
Prostate cancer
SRD5A2; ARAF; NDRG1; CCNE2; CASP9; NKX3-1; PIK3R1; INS; TGFA; BCL2
Chronic myeloid leukemia
TP53; GRB2; SHC3; STAT5B; HDAC1; IKBKG; SOS1; KRAS; MAP2K1; HRAS
Acute myeloid leukemia
PIK3CB; SOS1; CEBPA; IKBKB; NFKB1; RUNX1; AKT2; CHUK; RARA; STAT5A
Non-small cell lung cancer
PIK3CD; FHIT; CASP9; BRAF; MAP2K2; PRKCA; RASSF5; NRAS; PRKCB; RARB
Choline metabolism in cancer
WASL; PIK3CB; Pdgfa&Pdgfb; NRAS; CHKB; WASF1; MAPK9; SLC22A3; PRKCA; SLC22A2

Protein Function

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein ELMO2; CBLC; SH3BGRL2; SOS1; GRB2; DOCK4; PLSCR4; DNAJC6; ITM2B; SHANK1
Function SH3/SH2 adaptor activity
Related Protein RUSC1; CHN1; KHDRBS1; SKAP2; PAG1; SRC; FCRL2; CHN2; GRB2; SH2D3A
Function ephrin receptor binding
Related Protein ANKS1B; SIPA1L1; GRB2; SHC1; CBL; EFNB3B; EPHA7; EPHA4; EFNB2A; CDK5
Function epidermal growth factor receptor binding
Related Protein VAV2; EFEMP1; ARF4; HBEGF; CBLC; ATXN2; PLSCR1; EPGN; YES1; TGFA
Function identical protein binding
Related Protein TNPO3; CDC42; NQO1; BAK1; BCL2; SERPINA1D; TRIP10; TP63; HTT; TTN
Function insulin receptor substrate binding
Related Protein GRB2; INSRA; INSRB; IGF1RA; PIK3CB; JAK2; PIK3R1; INSRR; IGF1R; PIK3CA
Function neurotrophin TRKA receptor binding
Related Protein EFNA5; FRS2; PIK3R1; PLCG1; NGFR; SHC1; GRB2
Function phosphotyrosine binding
Related Protein LDLRAP1; SAMSN1; CBLB; PTPN3; ZAP70; MAPK1; MAPK3; GRB2; CBLC; FGR
Function poly(A) RNA binding
Related Protein ZFR; NOSIP; MTPAP; SYNCRIP; LTA4H; EDF1; RPS5; PUS7; PRPF4B; EIF4A3
Function protein binding
Related Protein TCHP; TPD52L3; LAIR1; PIAS3; C1QTNF9B-AS1; CD74; TTC37; TNKS2; DYNC1LI1; ATXN1L
Function protein kinase binding
Related Protein TRIB3; PTPRK; RCC2; FAM83A; DAXX; ACVRL1; MAP3K1; PRDX3; DNAJC3; KIF20A
Function protein phosphatase binding
Related Protein TRP53; TRAF3; ROS1; ITPR1; STAT3; ERBB2; TP53; PPARG; RPA2; MVP

Interacting Protein

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR

GRB2 Related Articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).