grb2
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  • Official Full Name
  • growth factor receptor-bound protein 2
  • Background
  • The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
Cat.#:GRB2-5038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST-tagged
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Cat.#:GRB2-5248HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST/His-tagged
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Cat.#:GRB2-127HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 protein, T7/His-tagged
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Cat.#:GRB2-13520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, GST-tagged
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Cat.#:GRB2-28345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, His-tagged
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Cat.#:GRB2-28483THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2
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Cat.#:GRB2-435HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GRB2 protein, His-tagged
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Cat.#:GRB2-4847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
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Cat.#:GRB2-500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-bound Protein 2, His-tagged
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Cat.#:GRB2-2686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB2 Protein
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Cat.#:GRB2-565CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GRB2 Protein, His-tagged
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Cat.#:GRB2-5981CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB2
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Cat.#:GRB2-5755HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB2 293 Cell Lysate
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Involved Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
DUSP8A; NFKB1; FGF6B; PRKCG; ARR3B; PRKCB; FGF5; MAPK13; MAP3K1; GADD45G
ErbB signaling pathway
GRB2; ERBB4; PLCG2; HRASB; PAK2; ARAF; CAMK2D; RPS6KB1B; PLCG1; ABL2
Ras signaling pathway
ABL1; RASA4; FGF13; PLA2G3; Fasl; RGL1; LOC608458; PTPN11; MAPK10; NFKB1
Chemokine signaling pathway
PLCB4; HCK; GNB1; CCL11; PLCB2; RASGRP2; RAP1B; CCL3L1; BCAR1; GNG3
FoxO signaling pathway
TGFB1A; FOXO1B; IRS4; G6PCA.1; SGK2B; SGK2; RBL2; MAPK14B; SLC2A4; GRB2
Phospholipase D signaling pathway
MRAS; PTK2B; PLCG2; GRB2; PLCB1; FCER1A; HRAS; KIT; DGKD; AGTR1A
PIK-Akt signaling pathway
TCL1B1; PIK3R5; COL6A6; TP53; COL4A1; KITLG; FGF16; ANGPT2; CREB3L3; STK11
Dorso-ventral axis formation
NOTCH2; PIWIL2; NOTCH1B; NOTCH4; GRB2A; CPEB4; ETS2; EGFRA; NOTCH3; CPEB1A
Osteoclast differentiation
MAP3K7; TGFBR2; CYLD; cgr2b; GRB2; CSF1R; NFKB2; SOCS1; BTK; LILRA1
Focal adhesion
MYL9; ZYX; PRKCB; PIK3CA; ERBB2; AKT1; TNC; PDGFAB; IGF1; PAK6B
Gap junction
PLCB4; GNAIA; PRKCBA; TUBA8L3; TJP1; TUBA7L; TUBA3E; GRM1; TUBA2; MAP2K2A
Signaling pathways regulating pluripotency of stem cells
AXIN1; WNT10B; PCGF6; MAPK1; IGF1R; APC; Fzd4; SMAD4; POU5F1; BMP2
Jak-STAT signaling pathway
IFNPHI3; CSH2; AOX1; PRL; BCL2A; IL15; PIM1; PRLRA; RAF1B; IFNA12
Natural killer cell mediated cytotoxicity
PRKCA; TNF; FCGR3; SHC4; PPP3CC; KLRC3; SAMD3; IFNA2; PLCG1; ITGAL
T cell receptor signaling pathway
AKT1; PTPRC; GRAPA; PIK3R5; CBL; GSK3B; PIK3R3; NFATC3; PIK3R1; CD3D
B cell receptor signaling pathway
NFATC2; CD22; PIK3CD; CD79A; PIK3R3; FOS; LYN; cgr2b; DOK1; Cd79a, Cd79b
Fc epsilon RI signaling pathway
PLA2G4F; GRB2; KRAS; PIK3R3; RAC2; MAPK9; FYN; PIK3CD; MAPK13; LYN
Neurotrophin signaling pathway
MATK; GRB2; NTRK2; CAMK2B; RIPK2; MAP2K5; BAD; BAX; RAC1; PIK3CG
Insulin signaling pathway
ACACB; CBL; RPTOR; RHEB; FLOT1B; LIPE; HKDC1; PDPK1; PIK3CA; FLOT1A
GnRH signaling pathway
FSHB; GNAS; HRAS; MAP2K2B; MAPK11; CALM1; CALM3; EGFRA; MAP2K1; RAF1B
Estrogen signaling pathway
PLCB2; SHC3; AKT2; PIK3CB; HSPA2; MMP2; HSP90AA1; SRC; HSPA8; SOS1
Prolactin signaling pathway
LHCGR; SOCS4; RAF1; MAPK3; PIK3R5; MAPK1; KRAS; STAT1; SHC2; GRB2
Alcoholism
HIST1H3D; HIST1H2AP; HIST1H2BA; H2AFB1; MAPK1; GRIN3A; HIST1H2AD; HIST1H2BB; CALM4; MAOA
Hepatitis C
PPARA; CLDN1; PIK3R1; PPP2R2D; IRF3; TRAF3; MAVS; IFN-a; IL-8; TP53
Hepatitis B
IFNA8; Fasl; STAT1; NFATC3; PIK3CG; NFATC1; IFNA17; STAT6; PTEN; PIK3CA
Pathways in cancer
GNG12; Fasl; RARA; LAMB2; TCF7L2; PIK3CB; HIF1A; MMP1; PLD1; CSF1R
Viral carcinogenesis
HIST1H2BL; HDAC1; STAT3; HIST1H4A; YWHAH; CREB5; NRAS; PKM2; PKM; HIST1H2BB
Proteoglycans in cancer
MTOR; TP53; ANK2; CAV1; ARHGEF12; AKT1; COL21A1; PRKACA; TGFB1; ERBB4
MicroRNAs in cancer
RAF1; PDGFRB; ZEB2; STAT3; SIRT1; HDAC1; VIM; MDM4; APC; PRKCB
Renal cell carcinoma
RAF1; TGFB1; FH1; EP300; VEGFA; HRAS; PAK1; PAK7; PAK3; NRAS
Endometrial cancer
PIK3R5; AKT2; PTEN; MLH1; LEF1; PIK3R2; PIK3CD; TRP53; APC; TP53
Glioma
TRP53; CALML3; TGFA; CAMK2G; CCND1; PLCG1; TP53; MTOR; PIK3CD; IGF1R
Prostate cancer
MAPK1; SOS1; PDGFD; PIK3CD; NKX3; PDGFB; LEF1; IKBKB; CCNE2; RELA
Chronic myeloid leukemia
GAB2; CBLC; MAP2K1; PIK3CD; CTBP1; PIK3R2; SHC1; HDAC2; PIK3CG; SOS1
Acute myeloid leukemia
PIK3CB; FLT3; PPARD; IKBKB; PIK3CD; STAT3; IKBKG; CCNA1; TCF7L2; PIK3CA
Non-small cell lung cancer
RASSF5; CCND1; PIK3CG; ARAF; PIK3CD; PRKCB; MAP2K1; PLCG2; PIK3CB; PLCG1
Choline metabolism in cancer
PDGFD; PLA2G4A; PRKCG; PIK3R2; TSC1; NRAS; PIP5K1B; PIK3CD; WAS; DGKB

Protein Function

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein CIT; DTX1; LRP2; ARHGAP6; CNTNAP1; VASPA; ADAM12; NOXA1; CASP9; SIRPA
Function SH3/SH2 adaptor activity
Related Protein NCK1; STAP1; SH2B2; ARHGAP4; CRK; BLNK; GAB1; SH2D3C; SH2D2A; FCRL2
Function ephrin receptor binding
Related Protein EFNB2B; EFNB2A; EFNA1; EFNA3; EFNA2; SHC1; EFNB1; CDK5R1; SIPA1L1; NTRK3
Function epidermal growth factor receptor binding
Related Protein HBEGFB; LINGO1B; TGFA; AREG; EREG; SOCS5; HBEGF; PLSCR1; Fert2; CBLC
Function identical protein binding
Related Protein SMURF2; KIRRELA; WRNIP1; S100A1; ANXA4; TPRG1L; ALK; SORD; ACY3; MICALL1
Function insulin receptor substrate binding
Related Protein PRKCD; INSR; INSRB; PTPN11; INSRR; PIK3R1; JAK2; PIK3CA; PRKCZ; IGF1RA
Function neurotrophin TRKA receptor binding
Related Protein PLCG1; SHC1; PIK3R1; EFNA5; NGFR; FRS2; GRB2
Function phosphotyrosine binding
Related Protein MAPK1; FGR; MAPK3; SAMSN1; STAP1; GRB2; CBLB; PTPN3; SHC1; LDLRAP1
Function poly(A) RNA binding
Related Protein CSDE1; CRKL; ILF3; LAS1L; ALDOA; EBI3; PDIA4; HNRNPAB; EIF3L; MECP2
Function protein binding
Related Protein ATP6V1E2; HIST1H4H; CXCL14; C7orf50; RARS; HIST1H3G; RPAP1; PUM1; CDCA8; NUBP2
Function protein kinase binding
Related Protein LAT; CEP152; SLC12A4; AP1B1; SLC12A7; AKAP1; KIF11; PPME1; APC; CDKN2C
Function protein phosphatase binding
Related Protein PIK3R1; TP53; ERBB2; PPP1R3G; PIK3R2; SHOC2; FLT4; RPA2; ANAPC5; CDKN1B

Interacting Protein

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR

GRB2 Related Articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).