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GRB2

  • Official Full Name

    growth factor receptor-bound protein 2

  • Overview

    The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Flag
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • No tag
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRB2-127H Recombinant Human GRB2 protein, T7/His-tagged E.coli T7/His
Human GRB2-4847H Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged E.coli GST
Human GRB2-13520H Recombinant Human GRB2, GST-tagged E.coli GST 1-214a.a.
Human GRB2-435H Recombinant Human GRB2 protein, His-tagged HEK293F His Met1~Val217
Human GRB2-28345TH Recombinant Human GRB2, His-tagged E.coli His
Human GRB2-5248H Recombinant Human GRB2 Protein, GST/His-tagged E.coli GST/His
Human GRB2-28483TH Recombinant Human GRB2 E.coli N/A
Human GRB2-500H Recombinant Human Growth Factor Receptor-bound Protein 2, His-tagged E.coli His
Human GRB2-5755HCL Recombinant Human GRB2 293 Cell Lysate HEK293 N/A
Human GRB2-5038H Recombinant Human GRB2 Protein, GST-tagged Wheat Germ GST
Human GRB2-001H Recombinant Human GRB2 Protein, His-GST-tagged E.coli His/GST 1-217
Human GRB2-0074H Recombinant Human GRB2 Protein (E2-V217), His tagged E.coli His E2-V217
Human GRB2-1017H-B Recombinant Human GRB2 Protein Pre-coupled Magnetic Beads HEK293
Human GRB2-1171HFL Recombinant Full Length Human GRB2 Protein, C-Flag-tagged Mammalian cells Flag
Human GRB2-151H Recombinant Human GRB2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human GRB2-3062H Recombinant Human GRB2 Protein (Met1-Val217), C-His tagged E.coli C-His Met1-Val217
Human GRB2-1017H Recombinant Human GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GRB2-002H Recombinant Human GRB2 Protein, His-tagged E.coli His 1-217
Human GRB2-0073H Recombinant Human GRB2 Protein (E2-V217), Tag Free E.coli No tag E2-V217
Human GRB2-5320HF Recombinant Full Length Human GRB2 Protein, GST-tagged In Vitro Cell Free System GST 217 amino acids
Mouse Grb2-1054M Recombinant Mouse Grb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat GRB2-2686R Recombinant Rat GRB2 Protein Mammalian Cell His
Rat GRB2-2340R Recombinant Rat GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRB2-2340R-B Recombinant Rat GRB2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GRB2-565C Recombinant Cynomolgus GRB2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GRB2-311C Recombinant Cynomolgus Monkey GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey GRB2-311C-B Recombinant Cynomolgus Monkey GRB2 Protein Pre-coupled Magnetic Beads HEK293
Chicken GRB2-5981C Recombinant Chicken GRB2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRB2 Related Articles
  • GRB2 Related Research Area
  • GRB2 Related Signal Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNG1A;GNA12A;FGF3;CACNA2D1;PDGFAA;MAPK12;FGF4;FGF13B;RAF1
ErbB signaling pathwayPAK2A;NCK1;PAK2;PIK3CD;BTC;CAMK2D;CDKN1BB;MAP2K2;ERBB2
Ras signaling pathwayFIGF;ANGPT4;FGF17;ARF6;PLA2G10;PRKCG;FGF20;PLA2G4C;VEGFC
Chemokine signaling pathwayCCL21;PLCB1;CXCR4;CCR8;CCL3;PIK3R2;ARRB1;CCR10;ARRB2
FoxO signaling pathwayTGFB2;SKP2;PLK4;HRASB;TGFBR1A;SLC2A4;PLK2B;TGFB1A;PRKAG3
Phospholipase D signaling pathwayLPAR3;CYTH2;PIK3R2;RRAS;NRAS;PTGFR;INSR;PDGFB;KITLG
PIK-Akt signaling pathwayPPP2CA;ANGPT2;CCNE2;ITGA9;IL3RA;IFNA16;THBS2;TEK;TNXB
Dorso-ventral axis formationNOTCH4;ETV7;SPIRE2;NOTCH1B;PIWIL1;NOTCH3;CPEB2;NOTCH1;PPP1R2P9
Osteoclast differentiationTGFBR2;IFNAR1;NFKB2;FCGR2B;MAPK8;NFATC1;FCGR2C;FCGR3;TEC
Focal adhesionMAP2K1;CDC42;MYL12.2;PAK3;VAV1;COL1A1A;SPP1;MAPK6;LAMB1A
Gap junctionLPAR1;PRKG1;GNA11B;TUBA8L3;ADCY2B;SOS1;GUCY1A3;TUBA1A;GNAI2B
Signaling pathways regulating pluripotency of stem cellsNANOG;WNT9B;BMP2;PAX6;PIK3CB;PIK3R3;INHBA;SKIL;ZIC3
Jak-STAT signaling pathwaySOCS3B;PIM1;SOCS1;IL15RA;IFNK;PRL2;SOCS6;IFNW1;SOCS3
Natural killer cell mediated cytotoxicityIFNG;NRAS;MAP2K2;IFNA6;IFNAR2;TYROBP;H60a;SOS1;ITGAL
T cell receptor signaling pathwayPIK3R3;PPP3R1;AKT1;PIK3CA;CD3G;CD28;PIK3R2;GRAP2;PPP3CA
B cell receptor signaling pathwayACTR3;HRAS;SYK;PIK3CG;PIK3AP1;SLA2;RAC1;ARPC3;CD79A
Fc epsilon RI signaling pathwayFCER1G;PLA2G4A;LAT;PIK3R5;PIK3CB;PIK3R1;RAC1;GM-CSF;VAV1
Neurotrophin signaling pathwayPIK3R2;SOS1;SHC2;CALM1;PLCG2;FASLG;BDNF;MAP2K5;PRDM4
Insulin signaling pathwayIRS1;PYGL;RAPGEF1;PRKACBB;MKNK2;PRKAG1;TSC2;PRKAG3B;PPP1CBL
GnRH signaling pathwayMAPK1;CAMK2G1;CALM1B;MAPK8A;GRB2B;CACNA1SA;ELK1;MAPK8;Adcy4
Estrogen signaling pathwayCREB3L1;CALM2;ITPR1;GRM1;PRKCD;PIK3R5;PRKACG;ESR2;GNAI3
Prolactin signaling pathwaySOS1;STAT1;GRB2;MAPK13;TNFRSF11A;SIRPA;MAPK10;FOXO3;PIK3CD
AlcoholismHIST1H2AF;CALML3;BDNF;CREB3L2;ATF6B;SLC18A1;HIST1H2AC;GNG4;HIST1H2BP
Hepatitis CIFN-a;STAT2;IFNA7;PIK3R1;IRF9;PIAS1;TBK1;IFNA4;IFNA21
Hepatitis BTLR2;TLR3;CREB3L3;TNF;BAD;MAPK10;TBK1;EGR2;DDX58
Pathways in cancerWNT8A;Ar;BCR;WNT9A;RXRB;RALGDS;KIT;LPAR5;WNT3
Viral carcinogenesisSRF;HIST1H2BH;GTF2A1L;HIST1H2BO;HLA-A;CCND2;TBPL2;BAX;TBPL1
Proteoglycans in cancerTRP53;ITGAV;PPP1R12B;MTOR;PRKACA;HGF;FLNA;STAT3;MET
MicroRNAs in cancerDNMT1;IGF2BP1;APC;CCND2;PTEN;ITGA5;HDAC4;RHOA;APC2
Renal cell carcinomaTGFB3;CDC42;FH1;AHA-1;VHL;EPAS1;SOS1;SLC2A1;TGFB2
Endometrial cancerARAF;TP53;MAP2K2;TCF7;PDPK1;TCF7L2;HRAS;AKT2;NRAS
GliomaCAMK2G;IGF1;PTEN;TGFA;PIK3CG;CAMK2A;AKT2;PIK3R5;PDGFRB
Prostate cancerSOS1;NKX3-1;PDGFRA;SPINK1;CCND1;INS;ACTL6B;ATF4;AKT2
Chronic myeloid leukemiaMECOM;CBLC;CRK;BCR;ABL1;KRAS;PIK3R1;MAPK1;GAB2
Acute myeloid leukemiaPIK3R5;TCF7L2;RARA;MYC;KRAS;MAPK3;NRAS;IKBKG;PPARD
Non-small cell lung cancerNRAS;PRKCA;RB1;MAP2K2;TP53;PIK3CG;PIK3CA;PIK3CD;TGFA
Choline metabolism in cancerPIK3R2;RAF1;SP1;PPAP2C;PDGFB;TAE1;DGKG;RAC1;WAS

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingPTTG1;SHANK2;ARHGAP31;MYPN;PTPN22;NCF1;QKI;SH3BP2;ABI2
SH3/SH2 adaptor activityITSN2;SH2D2A;LASP1;SKAP1;STAP1;SH2D1A;CNTNAP1;FCRL2;GAB1
ephrin receptor bindingEFNB2A;CDK5R1;PIK3CG;EFNA2A;SHC1;CDK5;EPHA4;SDCBP;EFNA1A
epidermal growth factor receptor bindingCBLC;YES1;LINGO1B;SHC1;AREG;HBEGF;HBEGFB;SNX2;HBEGFA
identical protein bindingEPHA4;ALDOA;APOE;AXIN1;PFKL;LCK;BRAF;PLEKHH2;RALYL
insulin receptor substrate bindingIGF1RB;PIK3CB;PTPN11;INSRB;GRB2;IGF1RA;PIK3CA;PIK3R1;PRKCD
neurotrophin TRKA receptor bindingNGFR;GRB2;PLCG1;PIK3R1;EFNA5;SHC1;FRS2
phosphotyrosine bindingSAMSN1;CBL;ACP2;CBLB;MAPK1;STAP1;PTPN3;MAPK3;LDLRAP1
poly(A) RNA bindingRPS2;C14orf93;TRMT2A;DDX31;GRN;EEF1A1;UBC;MTDH;OTUD4
protein bindingSDHAF2;RAB3IP;PPFIA4;GAGE5;HAPLN2;MEIOB;SGIP1;SOX-2;KIF20A
protein kinase bindingKCNQ3;DNAJA3;CLTC;TOM1L1;PPP1CC;PPP1R12C;PXN;DVL1;EEF1A1
protein phosphatase bindingFGF19;SNX3;TRAF2;PIK3R2;RPA3;PIK3R1;MAP3K5;KAT2A;VCAN

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.

EGFR

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).
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