grb2
Share
  • Official Full Name
  • growth factor receptor-bound protein 2
  • Background
  • The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
Cat.#:GRB2-5038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST-tagged
+Inquiry
Cat.#:GRB2-5248HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST/His-tagged
+Inquiry
Cat.#:GRB2-127HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 protein, T7/His-tagged
+Inquiry
Cat.#:GRB2-13520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, GST-tagged
+Inquiry
Cat.#:GRB2-28345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, His-tagged
+Inquiry
Cat.#:GRB2-28483THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2
+Inquiry
Cat.#:GRB2-435HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GRB2 protein, His-tagged
+Inquiry
Cat.#:GRB2-4847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
+Inquiry
Cat.#:GRB2-500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-bound Protein 2, His-tagged
+Inquiry
Cat.#:GRB2-2686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB2 Protein
+Inquiry
Cat.#:GRB2-565CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GRB2 Protein, His-tagged
+Inquiry
Cat.#:GRB2-5981CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB2
+Inquiry
Cat.#:GRB2-5755HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB2 293 Cell Lysate
+Inquiry

Involved Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA2D4; RASA2; PDGFRB; FGFR1A; RASA1; HRAS; CASP3A; FGF13B; PPP3CC; CACNA1D
ErbB signaling pathway
HBEGFB; PTK2; CBLB; MAP2K4A; EREG; MAPK9; AKT2L; CAMK2D; CAMK2D1; MAP2K4B
Ras signaling pathway
CALML5; GNGT1; PLD2; GNG5; SHC3; PLA2G3; RAP1B; BAD; RALB; FGF12
Chemokine signaling pathway
HCK; AMCF-II; NRAS; Ccl9; RLN1; GNG13; SHC1; CCL14; GSK3A; IKBKG
FoxO signaling pathway
RAF1; CCND1; KLF2B; MAP2K1; SOD2; MAP2K2A; HRASA; PCK2; PIK3CA; FOXO1
Phospholipase D signaling pathway
PIP5K1B; PLA2G4F; PIK3R1; TSC2; RRAS2; INS2; MAP2K1; INS; PDGFA; PLCG1
PIK-Akt signaling pathway
MCL1; PCK1; LPAR3; CCNE2; CCND2; IL7; COL27A1; Ifna15; IKBKB; Reln
Dorso-ventral axis formation
NOTCH2; PIWIL1; CPEB1B; NOTCH1; SPIRE2; ETS2; NOTCH1A; NOTCH4; MAPK3; GRB2B
Osteoclast differentiation
FYN; cgr2b; STAT1; LILRB3; LILRB5; RELA; SFPI1; FCGR3A; PIK3CA; TNF
Focal adhesion
PPP1CBL; VEGFC; COL6A6; RAP1AA; ITGB8; PPP1CAA; ROCK2B; RHOAA; ZYX; PPP1CA
Gap junction
MAPK1; TUBA8L4; ADCY2B; GJA1; PRKACBB; PRKACB; GNA11B; HTR2B; MAP2K2; CSNK1DB
Signaling pathways regulating pluripotency of stem cells
INHBC; SMAD5; WNT4; WNT3A; MAPK12; MAPK3; DLX5; FGFR1; LHX5; FZD1
Jak-STAT signaling pathway
PIK3R5; GM13305; IFNA13; STAT5A; IFNAR2; Ifna11; IL20RB; JAK2B; HRASA; PIM1
Natural killer cell mediated cytotoxicity
PRF1; NCR1; GRB2; FCER1G; SYK; PPP3CC; ITGB2L; IFNA10; PRKCB; NCR2
T cell receptor signaling pathway
GSK3B; FOS; IKBKG; NFKBIA; PAK6; MAP2K2; NFKBIE; CD4; AKT2; NCK2
B cell receptor signaling pathway
ARPC3; PDK2; CD79A; BANK1; DOK1B; PIK3CB; BTK; RAC1; FOS; PLEKHA2
Fc epsilon RI signaling pathway
LYN; MAPK3; PIK3CB; IL4; FCER1G; MAP2K1; PLA2G4D; MAP2K3; PIK3R3; VAV3
Neurotrophin signaling pathway
MAPKAPK2; RELA; CALM4; NFKBIB; GSK3B; KIDINS220; SOS1; MAGED1; TP53; MAP3K3
Insulin signaling pathway
PRKACAA; GRB2B; PPP1R3DA; PIK3R3A; IKBKB; CALM2A; PRKAA2; RAF1B; INSB; INSR
GnRH signaling pathway
SRC; PRKACA; CALM1A; CAMK2D2; PRKACB; ITPR1; MAP2K2B; MAP3K1; CAMK2D; MAPK7
Estrogen signaling pathway
GNAS; FKBP5; KCNJ5; CALML5; GPR30; HSPA6; PIK3R2; HSPA8; CREB3L3; GNAI1
Prolactin signaling pathway
LHB; GSK3B; PIK3CA; MAPK9; PIK3R1; MAPK12; MAPK11; SHC1; ELF5; PIK3CB
Alcoholism
H2BFWT; GNG13; HIST1H2BB; HIST1H4H; HIST1H2BO; HIST1H4N; H2AFY2; HIST1H3A; HIST2H3C1; GNAI2
Hepatitis C
Ifna11; OSTN; RNASEL; CLDN4; NFKBIA; EIF3E; CLDN2; EIF2AK2; MAPK13; CLDN10
Hepatitis B
Ifna15; BCL2; IFNA12; STAT4; FASLG; IFNA8; CYCS; STAT6; IRF3; BIRC5
Pathways in cancer
ETS1; PTCH2; PPARD; Adcy4; WNT7B; NRAS; MSH6; GNG10; MSH2; HSP90B1
Viral carcinogenesis
IRF3; PRKACG; BAD; ACTN1; HIST1H2BF; TRAF1; KAT2A; PIK3CB; HLA-C; CCNE2
Proteoglycans in cancer
CD44; IGF1R; FAS; ACTB; PAK1; FLNC; TLR4; PLCG2; ESR1; IGF1
MicroRNAs in cancer
RPTOR; ROCK1; CDC25B; PRKCG; CYP24A1; SERPINB5; VEGFA; HDAC4; RPS6KA5; TRIM71
Renal cell carcinoma
PIK3R5; MET; GRB2; FH; HIF1A; PAK1; TGFB2; SLC2A1; VEGFA; MAPK1
Endometrial cancer
ELK1; NRAS; MAP2K2; CTNNA2; PIK3CG; APC; TRP53; ARAF; PIK3R5; PIK3CD
Glioma
SHC2; PIK3CG; PDGFB; PDGFRB; MTOR; CALM4; PIK3CB; CALML5; CCND1; PDGFA
Prostate cancer
PDGFD; TGFA; TCF7; CREB3L3; INS2; PDGFB; NFKB1; ARAF; FGFR2; CCNE2
Chronic myeloid leukemia
BRAF; MAP2K1; PIK3R1; IKBKB; RAF1; MECOM; CTBP2; SMAD3; ARAF; PIK3R3
Acute myeloid leukemia
MAP2K2; IKBKB; EIF4EBP1; SPI1; LEF1; STAT5A; BAD; STAT3; CEBPA; CCNA1
Non-small cell lung cancer
RARB; FOXO3; RXRG; PRKCA; BAD; PDPK1; EML4; PIK3CA; GRB2; KRAS
Choline metabolism in cancer
AKT2; WASF2; PDGFD; PIK3CD; TAE1; Pdgfa&Pdgfb; PIK3R2; LYPLA1; MAP2K2; MAP2K1

Protein Function

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein INPPL1B; NOXA1; KHDRBS1; SOS1; MICAL1; QKI; ABI2; ENKUR; CCDC6; QK
Function SH3/SH2 adaptor activity
Related Protein GRB10; LAT; EPS8; SH2D2A; SH2D3C; NCK1; CHN1; HSH2D; CNTNAP1; KHDRBS1
Function ephrin receptor binding
Related Protein EFNA2; GRB2; EFNA2A; SDCBP; EFNB1; PTPN1; EFNB2; EFNB2B; CHN1; EFNA1B
Function epidermal growth factor receptor binding
Related Protein EGF; AREG; YES1; RNF126; Fert2; FAM83B; SNX2; EFEMP1; LINGO1; HBEGFA
Function identical protein binding
Related Protein MTPAP; HJURP; FGFR1; FHOD1; NME1; SMAD4; COIL; DRG1; TRP63; GAPDH
Function insulin receptor substrate binding
Related Protein GRB2; PRKCD; INSRA; INSRR; PTPN11; PIK3R1; IGF1RA; PIK3CB; JAK2; PIK3CA
Function neurotrophin TRKA receptor binding
Related Protein FRS2; EFNA5; NGFR; SHC1; PLCG1; GRB2; PIK3R1
Function phosphotyrosine binding
Related Protein MAPK1; STAP1; CBLC; FGR; GRB2; CBL; LDLRAP1; SAMSN1; MAPK3; SHC1
Function poly(A) RNA binding
Related Protein SRSF9; RBM38; SRSF7; ROCK2; GTPBP10; MRPL13; DDX21; CRNKL1; ZCCHC8; MYBBP1A
Function protein binding
Related Protein ZFYVE1; CD81; CCDC24; IGSF21B; TOM1; MGRN1; ABHD14B; CRYBB3; YIPF4; EDA2R
Function protein kinase binding
Related Protein CCND2; ZBTB4; TPRKB; PRKAG2; PTPRC; RB1CC1; CDH2; CCNB3; VRK1; H2AFY
Function protein phosphatase binding
Related Protein CDH2; CSK; TP53; MAP2K7; NEK2; TRP53; RPA3; MET; DRD1; JAK3

Interacting Protein

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR

GRB2 Related Articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).