grb2
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  • Official Full Name
  • growth factor receptor-bound protein 2
  • Background
  • The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
Cat.#:GRB2-5038HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST-tagged
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Cat.#:GRB2-5248HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 Protein, GST/His-tagged
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Cat.#:GRB2-127HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2 protein, T7/His-tagged
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Cat.#:GRB2-13520HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, GST-tagged
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Cat.#:GRB2-28345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2, His-tagged
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Cat.#:GRB2-28483THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB2
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Cat.#:GRB2-435HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human GRB2 protein, His-tagged
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Cat.#:GRB2-4847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
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Cat.#:GRB2-500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-bound Protein 2, His-tagged
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Cat.#:GRB2-2686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB2 Protein
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Cat.#:GRB2-565CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GRB2 Protein, His-tagged
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Cat.#:GRB2-5981CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB2
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Cat.#:GRB2-5755HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB2 293 Cell Lysate
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Involved Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPKAPK5; MAP3K12; GADD45BA; MAPK10; RAC2; FGF1B; MAP3K1; MAP2K2A; PPM1AA; HSPA1B
ErbB signaling pathway
PRKCB; GSK3B; AKT2L; CAMK2B; AKT2; RAF1B; CAMK2G1; NRAS; TGFA; ARAF
Ras signaling pathway
GNG8; RAF1; GNG7; RASA4; FGF6; PLA2G2F; MET; MAP2K2; CDC42; REL
Chemokine signaling pathway
CXCL8; ITK; CX3CL1; PIK3CG; CXCL5; ARRB2; CX3CR1; NCF1; CCL19; CCL24
FoxO signaling pathway
PIK3CB; GRM1; MAP2K1; HOMER1B; PLK1; RBL2; FBXO25; CCNG2; NLK1; BNIP4
Phospholipase D signaling pathway
AKT2; KITLG; AGTR1B; DNM3; PLCG1; CXCR1; MAP2K2; RRAS; PLCB1; RALB
PIK-Akt signaling pathway
PKN1; IL2RA; CCND1; PPP2R3C; CASP9; PPP2R5D; FASLG; GNB3; FGF9; FGF17
Dorso-ventral axis formation
ETS1; MAP2K1; ETV7; FMN2; NOTCH4; GRB2; GRB2A; SPIRE1; PPP1R2P9; PIWIL4
Osteoclast differentiation
IL1B; IL1R1; TNFSF11; LILRA1; OSCAR; TEC; PPARG; STAT1; FCGR2A; CSF1
Focal adhesion
VAV3; MYLK3; ITGA9; CCND1; RAC3B; CCND3; PXNA; ROCK1; ACTG1; VEGFB
Gap junction
MAPK3; PLCB4; TUBB6; PDGFRB; HTR2A; TUBA8L; DRD1B; TJP1; TUBA4A; TUBA3C
Signaling pathways regulating pluripotency of stem cells
ACVR1; HESX1; MAP2K2; WNT5B; ESRRB; ID3; PCGF6; WNT16; SMAD9; PIK3R3
Jak-STAT signaling pathway
PIAS1; PRL; GRB2B; LIF; SOCS6; AKT2; HRASA; PTPN11; IFNA4; LIFR
Natural killer cell mediated cytotoxicity
IFNAR1; NCR1; RAF1; VAV3; IFNA10; HLA-G; HLA-B; TNFRSF10A; FCGR3B; TYROBP
T cell receptor signaling pathway
CD3D; PIK3R5; IL4; CBLB; MAP2K7; PPP3R1; NCK1; CD3G; TNF; MAPK9
B cell receptor signaling pathway
BANK1; IGHM; VAV1; DOK1; NFATC3; CD79A; GRB2; VAV2; CDK6; MAP2K1
Fc epsilon RI signaling pathway
MAPK9; MAP2K4; NRAS; MAPK10; PLA2G4C; FCER1A; AKT2; RAF1; PDPK1; PIK3CA
Neurotrophin signaling pathway
CAMK2B; PIK3CA; NTF4; KIDINS220; IKBKB; NFKBIE; CALML3; PIK3CB; FASLG; MAP3K1
Insulin signaling pathway
PPP1CB; SOCS9; MKNK2A; FLOT1; FLOT2A; FOXO1A; INPPL1; MAPK8B; HK2; MAP2K2A
GnRH signaling pathway
SOS1; MAPK8B; EGFRA; HRASA; CACNA1C; PRKCB; RAF1; ATF4; MAP2K7; GNRH2
Estrogen signaling pathway
MAPK3; PIK3CB; CALML3; HSP90AA1; FKBP4; KCNJ6; HSPA8; ITPR3; SHC2; Adcy4
Prolactin signaling pathway
ELF5; SRC; ESR2; SOCS6; GALT; SOCS1; SOS1; SLC2A2; INS2; NEK3
Alcoholism
GNAO1; HIST1H4I; HIST1H4A; HIST1H2AG; HIST1H4H; HIST1H2AC; H2AFB3; HIST1H2BN; CALML5; CALM3
Hepatitis C
Ifna11; KRAS; CLDN22; IFNA21; MAPK12; CLDN18; AKT1; IFNA6; GRB2; CLDN5
Hepatitis B
MAPK9; STAT5A; NFATC1; FOS; PCNA; CYCS; MAPK10; MAPK8; TP53; CREB3L2
Pathways in cancer
RXRA; CBLB; PPARD; WNT2; ITGA6; LAMC1; RARB; PRKACB; LAMA2; GNG5
Viral carcinogenesis
VAC14; GTF2H1; PIK3CB; ACTN3; HIST1H4K; HPN; PMAIP1; HIST1H4B; HDAC11; TBPL1
Proteoglycans in cancer
GPC1; LUM; ANK1; GRB2; MAPK3; HSPG2; IGF1R; PXN; CAV3; ITGAV
MicroRNAs in cancer
PIK3R2; KIF23; HNRNPK; DNMT1; MARCKS; SOS1; MMP16; KRAS; ZEB1; CCNE1
Renal cell carcinoma
TGFB1; RAP1A; RBX1; ARNT; PAK2; TCEB2; PDGFB; PIK3CD; PIK3R1; AKT1
Endometrial cancer
GSK3B; TCF7; FOXO3; LEF1; CDH1; MLH1; AXIN2; MAPK3; PTEN; PIK3CA
Glioma
SHC2; TP53; HRAS; PDGFRA; MTOR; IGF1R; CALM3; KRAS; PIK3CB; IGF1
Prostate cancer
SMARCD1; INS1; CPN1; SPINK1; PDGFC; MAP4K1; BAD; PDGFD; CCNE2; FGFR2
Chronic myeloid leukemia
SOS1; PIK3CA; PIK3CD; STAT5A; MAPK3; RAF1; PIK3R1; PIK3R5; CRK; SMAD3
Acute myeloid leukemia
RUNX1T1; MAPK3; HRAS; ARAF; GRB2; SPI1; MAPK1; CCNA1; RAF1; NFKB1
Non-small cell lung cancer
RB1; PRKCG; EML4; RASSF5; CASP9; TRP53; KRAS; PLCG1; RXRB; PRKCB
Choline metabolism in cancer
HRAS; FOS; HIF1A; RAC3; PPAP2C; PIK3CA; PDGFD; PDGFB; SP1; DGKD

Protein Function

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein PTTG1; RAD9; DRD4; EPS15; KHDRBS1; WAS; ADAM12; QKI2; ZFP106; ADAM10
Function SH3/SH2 adaptor activity
Related Protein HSH2D; GRAP; SRC; PAG1; BLNK; SHB; GRB2; NCK2; STAP1; STAM
Function ephrin receptor binding
Related Protein Anks1; EFNA1B; CDK5; EFNA1A; EFNA2; EFNA3B; EFNB2A; CBL; EFNA4; EFNB2
Function epidermal growth factor receptor binding
Related Protein FAM83B; FER; TGFA; TNK2; CBLC; SNX1; HBEGFB; RNF126; ARF4; Fert2
Function identical protein binding
Related Protein S100A1; C1QTNF2; BTK; TRADD; WRNIP1; AGXT2L1; NLRC4; PHC2; DIAP1; TRAF6
Function insulin receptor substrate binding
Related Protein IGF1RB; INSRR; IGF1R; JAK2; PRKCZ; PIK3CA; PTPN11; GRB2; PRKCD; INSRB
Function neurotrophin TRKA receptor binding
Related Protein GRB2; FRS2; PLCG1; SHC1; PIK3R1; EFNA5; NGFR
Function phosphotyrosine binding
Related Protein CBL; STAP1; MAPK1; PTPN3; FGR; CBLB; GRB2; LDLRAP1; MAPK3; SAMSN1
Function poly(A) RNA binding
Related Protein NOLC1; ADARB2; CHD2; SUMO2; SNRPA; ADARB1; PEG10; KHDRBS1; NOP14; MRPL32
Function protein binding
Related Protein MRPL1; TICAM1; SULT2B1; GIMAP5; ATE1; RAB11FIP3; MAPK12; CYHR1; MGP; SYCE1
Function protein kinase binding
Related Protein RAD9A; KIF20A; XBP1; PTPN1; RPTOR; DOK7; CALM; MAP3K12; CNTLN; RHOD
Function protein phosphatase binding
Related Protein MAP2K7; AP3B1; HSP90B1; VCAN; GRB2; ANAPC5; KAT2A; MAPK14; PPME1; SNX3

Interacting Protein

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR

GRB2 Related Articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).