grb7
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  • Official Full Name
  • growth factor receptor-bound protein 7
  • Background
  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms
  • GRB7; growth factor receptor-bound protein 7; B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7_HUMAN; Growth factor receptor bound protein 7; OTTHUMP00000164349; OTTHUMP00000164350; OTTHUMP00000164351; OTTHUMP00000164352
Cat.#:GRB7-247HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB7 Protein, His-tagged
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Cat.#:GRB7-5316HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB7 Protein, GST-tagged
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Cat.#:Grb7-248MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Grb7 Protein, His-tagged
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Cat.#:GRB7-13521HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB7, His-tagged
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Cat.#:GRB7-27926THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GRB7
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Cat.#:GRB7-4848HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Factor Receptor-Bound Protein 7, GST-tagged
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Cat.#:GRB7-6971HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB7, GST-tagged
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Cat.#:GRB7-7247MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRB7 Protein
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Cat.#:GRB7-2687RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB7 Protein
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Cat.#:GRB7-5754HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GRB7 293 Cell Lysate
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Involved Pathway

GRB7 involved in several pathways and played different roles in them. We selected most pathways GRB7 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, Downstream signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Angiopoietin receptor Tie2-mediated signaling
GRB7; CRK; DOK2; ELF1; CDKN1A; BMX; GRB14; AGTR1; ELF2
Cell surface interactions at the vascular wall
F11R.2; FN1B; NADL1.1; SIRPA; FCER1GL; SLC16A8; GRB14; CEACAM6; ITGB1B.1; ESAMA
Downstream signal transduction
FGF20A; SPTB; RASGRP4; PTPRA; DUSP7; JAK1; TRAT1; SPTBN1; SPNA1; IL17RD
EGFR1 Signaling Pathway
SH2D3C; DNM1; CEBPB; ELF3; PLSCR1; KRT17; KRT8; RALBB; ZFP259; GRB10
EPHB forward signaling
EFNB1; EFNB3; EFNA5; ITSN1; GRB7; EFNB2
GRB7 events in ERBB2 signaling
GRB7
Hemostasis
ANGPT2A; CABLES1; HRG; RHOB; KIF3B; KLC3; GATA1A; F9A; TAE1; CD9B
Kit Receptor Signaling Pathway
DOK1B; GRAP; PTPRU; GRB10; GRB7; SOCS4; PTPRUB; STAP1; GRAPA; DOK1

Protein Function

GRB7 has several biochemical functions, for example, RNA binding, SH3/SH2 adaptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB7 itself. We selected most functions GRB7 had, and list some proteins which have the same functions with GRB7. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein EIF4B; DAZL; YY1; ASCC1; IFIT10; RPL24; IREB2; ENDOU; HNRNPH1; RPL4
Function SH3/SH2 adaptor activity
Related Protein RUSC1; GRB7; GAB1; SLA; SKAP1; SOCS2; PTPN11; GRB2; SLA2; STAM
Function identical protein binding
Related Protein ATL3; ZHX2; ACTN2; CLDN17; AKT1; S100A1; COL1A1; PUF60; PPPDE2; TP73
Function phosphatidylinositol binding
Related Protein ARHGAP32; SNX16; NISCH; CCDC88A; ARHGAP33; SNX17; NOXO1; FES; ESYT2; PASK
Function protein binding
Related Protein NOLC1; MTERFD2; RAB27A; STX4A; STON2; LRRC47; TBC1D1; SIAH1; IGSF1; FAM111A
Function protein kinase binding
Related Protein PDCD10; SMAD1; GPRC5B; PKD1; AP2A1; LIPE; RHOD; PARP1; TUBB3; CNPPD1

Interacting Protein

GRB7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB7.
ERBB2; ERBB3; KIT; RND1

GRB7 Related Articles

Murray, JC; Aldeghaither, D; et al. c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1186-1198(2014).
Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).

GRB7 Related Gene Family

TGF