Recombinant Human GRB7

• Cat.No.: GRB7-27926TH
• Product Overview: Recombinant full length Human GRB7 with N terminal proprietary tag; Predicted MW 84.59 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 532 amino acids
• Description: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
• Molecular Weight: 84.590kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVK RSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQ SPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLED HESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFP EKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNE SNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCS EDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQ AWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREE SQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILP CLLRHCCTRVAL
• Sequence Similarities: Belongs to the GRB7/10/14 family.Contains 1 PH domain.Contains 1 Ras-associating domain.Contains 1 SH2 domain.

Gene Information

• Gene Name: GRB7 growth factor receptor-bound protein 7 [ Homo sapiens ]
• Official Symbol: GRB7
• Synonyms: GRB7; growth factor receptor-bound protein 7
• Gene ID: 2886
• mRNA Refseq: NM_001030002
• Protein Refseq: NP_001025173
• MIM: 601522
• Uniprot ID: Q14451
• Chromosome Location: 17q12
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Downstream signal transduction, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; EPHB forward signaling, organism-specific biosystem
• Function: RNA binding; SH3/SH2 adaptor activity; identical protein binding; lipid binding; phosphatidylinositol binding