Recombinant Mouse Grb7 Protein, MYC/DDK-tagged

• Cat.No.: Grb7-1055M
• Product Overview: Purified recombinant protein of full-length mouse growth factor receptor bound protein 7 (Grb7), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 60 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Grb7 growth factor receptor bound protein 7 [ Mus musculus (house mouse) ]
• Official Symbol: Grb7
• Synonyms: Grb7; growth factor receptor bound protein 7; mKIAA4028; growth factor receptor-bound protein 7; GRB7 adapter protein; Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7); epidermal growth factor receptor GRB-7
• Gene ID: 14786
• mRNA Refseq: NM_010346
• Protein Refseq: NP_034476
• UniProt ID: Q03160