gsta3
Share
  • Official Full Name
  • glutathione S-transferase alpha 3
  • Background
  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
  • Synonyms
  • GSTA3; glutathione S-transferase alpha 3; glutathione S transferase A3; glutathione S-transferase A3; GST class-alpha member 3; glutathione S-transferase A3-3; glutathione S-aryltransferase A3; glutathione S-alkyltransferase A3; glutathione S-aralkyltrans
Cat.#:GSTA3-2462HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GSTA3 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:GSTA3-13571HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTA3, His-tagged
+Inquiry
Cat.#:GSTA3-27543THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GSTA3, GST-tagged
+Inquiry
Cat.#:GSTA3-7326MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GSTA3 Protein
+Inquiry
Cat.#:Gsta3-755MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gsta3 protein, His-tagged
+Inquiry
Cat.#:Gsta3-756RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gsta3 protein, His-tagged
+Inquiry
Cat.#:GSTA3-571CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GSTA3 Protein, His-tagged
+Inquiry
Cat.#:GSTA3-1988RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GSTA3 Protein, His-tagged
+Inquiry
Cat.#:GSTA3-1168CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GSTA3
+Inquiry
Cat.#:GSTA3-754CTag:His|T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken GSTA3 protein, His & T7-tagged
+Inquiry
Cat.#:GSTA3-2472HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutathione S-transferase Alpha 3
+Inquiry
Cat.#:GSTA3-758HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GSTA3 cell lysate
+Inquiry

Involved Pathway

GSTA3 involved in several pathways and played different roles in them. We selected most pathways GSTA3 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
MGST1; IDH1; GPX4; SMS; IDH2; GSTO1; GSTP1; GGT7; GSTM4; GPX3
Metabolism of xenobiotics by cytochrome P
DHDH; GSTA3; AKR7A5; AKR7A3; CBR1; UGT1A7C; UGT1A6; GSTM4; GSTM7; ADH1
Drug metabolism - cytochrome P
GSTA4; GSTM2; ALDH3A1; ALDH3B1; AOX2P; UGT5G1; AOX3; UGT1A4; MGST1; MGST1.1
Chemical carcinogenesis
ADH7; SULT1A3; UGT2A3; CYP3A25; ADH1B; GSTT2; GSTA1; GSTM1; CYP2C50; GSTM7

Protein Function

GSTA3 has several biochemical functions, for example, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTA3 itself. We selected most functions GSTA3 had, and list some proteins which have the same functions with GSTA3. You can find most of the proteins on our site.
Function
Related Protein
Function glutathione transferase activity
Related Protein EEF1E1; EEF1G; GSTAL; GSTA; MGST2; GSTT1B; GSTK1; GRX2; GSTA5; MGST1