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HAO1

  • Official Full Name

    hydroxyacid oxidase (glycolate oxidase) 1

  • Overview

    This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.
  • Synonyms

    HAO1; hydroxyacid oxidase (glycolate oxidase) 1; GOX1; hydroxyacid oxidase 1; GOX; (S) 2 hydroxy acid oxidase; Glycolate oxidase; HAOX1; HAOX1_HUMAN; MGC142225; MGC142227; OTTHUMP00000030231; (S)-2-hydroxy-acid oxidase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • N/A
  • TraxA|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HAO1-4570H Recombinant Human HAO1 Protein, GST-tagged Wheat Germ GST
Human HAO1-3795H Recombinant Human HAO1, His tagged E.coli His
Human HAO1-317H Recombinant Human HAO1 Protein, His-tagged E.coli His
Human HAO1-378H Recombinant Human HAO1 protein, His-tagged HEK293 His 369
Human HAO1-3612H Recombinant Human HAO1, His-tagged E.coli His
Human HAO1-99H Recombinant Human HAO1, TraxA/His-tagged E.coli TraxA/His
Human HAO1-5638HCL Recombinant Human HAO1 293 Cell Lysate HEK293 N/A
Human HAO1-1042H Recombinant Human HAO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HAO1-001H Active Recombinant Human HAO1 Protein, His-tagged E.coli His
Human HAO1-3351HF Recombinant Full Length Human HAO1 Protein, GST-tagged In Vitro Cell Free System GST 370 amino acids
Human HAO1-1042H-B Recombinant Human HAO1 Protein Pre-coupled Magnetic Beads HEK293
Human HAO1-796H Recombinant Human HAO1 Protein HEK293 370
Human HAO1-3820H Recombinant Human HAO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HAO1-1303HFL Recombinant Full Length Human HAO1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Hao1-840M Recombinant Mouse Hao1 protein, His/GST-tagged E.coli His/GST Ser113~Lys369
Mouse HAO1-839M Recombinant Mouse HAO1, without tag E.coli N/A
Mouse Hao1-4957M Recombinant Mouse Hao1 protein, His-tagged E.coli His 1-370aa
Mouse Hao1-1095M Recombinant Mouse Hao1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Hao1-458R Recombinant Rat Hao1 Protein, His-tagged E.coli His Gly102~Lys357
Zebrafish HAO1-5403Z Recombinant Zebrafish HAO1 Mammalian Cell His
Chicken HAO1-4308C Recombinant Chicken HAO1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HAO1 Related Articles

HAO1 involved in several pathways and played different roles in them. We selected most pathways HAO1 participated on our site, such as Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glyoxylate and dicarboxylate metabolismAMT;GCSH;ANI_1_2390104;GCSHA;ACAT1;ACO1;MDH2;PCCA;DHDPSL
Metabolic pathwaysPDHA1;HYAL3;CBR1;CBR2;ACSL1B;CYP26B1;DHRS4;THTPA;AMPD3
Carbon metabolismSHMT2;EHHADH;SUCLA2;ACSS1;HADHAA;ALDOA;OGDH;TPI1;PRPS2
PeroxisomeIDH1;ACOX1;PEX14;CRATA;AGXTB;ABCD3;HSD17B4;PEX12;PEX1

HAO1 has several biochemical functions, for example, (S)-2-hydroxy-acid oxidase activity, FMN binding, glycolate oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAO1 itself. We selected most functions HAO1 had, and list some proteins which have the same functions with HAO1. You can find most of the proteins on our site.

Function Related Protein
(S)-2-hydroxy-acid oxidase activityHAO1;HAO2
FMN bindingNOS1;MTRR;TYW1;NOS2A;NDOR1;CREG2;NOS2;DHODH;CREG1
glycolate oxidase activity
glyoxylate oxidase activity
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activityHAO2;HAO1
medium-chain-(S)-2-hydroxy-acid oxidase activityHAO1;HAO2
receptor bindingPTK2AA;LTB;IAPP;SRC;ANG;NRXN1;FASLG;RCHY1;IL28A
very-long-chain-(S)-2-hydroxy-acid oxidase activityHAO1;HAO2

HAO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAO1.

p27958-pro_0000037577

Frishberg, Y; Zeharia, A; et al. Mutations in HAO1 encoding glycolate oxidase cause isolated glycolic aciduria. JOURNAL OF MEDICAL GENETICS 51:526-529(2014).
Rungroj, N; Nettuwakul, C; et al. A whole genome SNP genotyping by DNA microarray and candidate gene association study for kidney stone disease. BMC MEDICAL GENETICS 15:-(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is HAO1 implicated in metabolic disorders? 02/14/2022

Dysregulation of HAO1 is linked to metabolic disorders and fatty liver disease.

Are there existing or potential therapeutic strategies targeting HAO1? 09/04/2021

Therapeutic approaches may include modulation of HAO1 activity or expression.

How does HAO1 contribute to fatty acid metabolism? 08/15/2020

It oxidizes specific fatty acids, contributing to their breakdown.

What are the key biological functions of HAO1? 07/14/2020

HAO1 is involved in peroxisomal fatty acid oxidation, crucial for lipid metabolism.

What are the potential consequences of HAO1 overexpression? 06/15/2020

HAO1 overexpression may lead to oxidative stress and liver dysfunction.

What role does HAO1 play in liver function? 01/01/2019

HAO1 supports liver function by participating in lipid catabolism.

How is HAO1 activity regulated in cells? 10/13/2018

Cellular regulation of HAO1 involves transcriptional and post-translational mechanisms.

Customer Reviews (3)

Write a review
Reviews
05/09/2022

    Worked well in experiments.

    11/28/2020

      Great for academic research.

      01/28/2020

        Very satisfied, will buy again.

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