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Official Full Name hydroxyacid oxidase (glycolate oxidase) 1
Background This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.
Synonyms HAO1; hydroxyacid oxidase (glycolate oxidase) 1; GOX1; hydroxyacid oxidase 1; GOX; (S) 2 hydroxy acid oxidase; Glycolate oxidase; HAOX1; HAOX1_HUMAN; MGC142225; MGC142227; OTTHUMP00000030231; (S)-2-hydroxy-acid oxidase
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    • TraxA
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HAO1-001H Recombinant Human HAO1 Protein, His-tagged E.coli His
    Mouse Hao1-1095M Recombinant Mouse Hao1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HAO1-3820H Recombinant Human HAO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HAO1-317H Recombinant Human HAO1 Protein, His-tagged E.coli His
    Human HAO1-3612H Recombinant Human HAO1, His-tagged E.coli His
    Human HAO1-378H Recombinant Human HAO1 protein, His-tagged HEK293 His
    Human HAO1-3795H Recombinant Human HAO1, His tagged E.coli His
    Human HAO1-4570H Recombinant Human HAO1 Protein, GST-tagged Wheat Germ GST
    Human HAO1-5638HCL Recombinant Human HAO1 293 Cell Lysate HEK293 N/A
    Human HAO1-99H Recombinant Human HAO1, TraxA/His-tagged E.coli TraxA/His
    Mouse HAO1-839M Recombinant Mouse HAO1, without tag E.coli N/A
    Mouse Hao1-840M Recombinant Mouse Hao1 protein, His/GST-tagged E.coli His/GST
    Rat Hao1-458R Recombinant Rat Hao1 Protein, His-tagged E.coli His
    Chicken HAO1-4308C Recombinant Chicken HAO1 Mammalian Cell His
    Zebrafish HAO1-5403Z Recombinant Zebrafish HAO1 Mammalian Cell His

    HAO1 involved in several pathways and played different roles in them. We selected most pathways HAO1 participated on our site, such as Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glyoxylate and dicarboxylate metabolism CS; PCCA; AGXTA; ACAT1; ACO1; AGXT; GLULA; DLDH; MDH1AA; SHMT2
    Metabolic pathways HOGA1; UROS; KCNG4; NDUFA1; SDHD; ATP6V1G2; PGAM2; RPN1; QDPRB2; ATP6V1H
    Peroxisome ACSL4; NOS2; GNPAT; BAAT; HACL1; EPHX2; PEX11B; SOD1; PIPOX; MPV17L

    HAO1 has several biochemical functions, for example, (S)-2-hydroxy-acid oxidase activity, FMN binding, glycolate oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAO1 itself. We selected most functions HAO1 had, and list some proteins which have the same functions with HAO1. You can find most of the proteins on our site.

    Function Related Protein
    (S)-2-hydroxy-acid oxidase activity HAO1; HAO2
    glycolate oxidase activity HAO1
    glyoxylate oxidase activity HAO1
    long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity HAO2; HAO1
    medium-chain-(S)-2-hydroxy-acid oxidase activity HAO1; HAO2
    receptor binding KCNA5; RND1; Icosl; NTF7; FGF6A; RCHY1; TIGIT; RARA; PVRL3; CLCF1
    very-long-chain-(S)-2-hydroxy-acid oxidase activity HAO1; HAO2

    HAO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAO1.


    Frishberg, Y; Zeharia, A; et al. Mutations in HAO1 encoding glycolate oxidase cause isolated glycolic aciduria. JOURNAL OF MEDICAL GENETICS 51:526-529(2014).
    Rungroj, N; Nettuwakul, C; et al. A whole genome SNP genotyping by DNA microarray and candidate gene association study for kidney stone disease. BMC MEDICAL GENETICS 15:-(2014).

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