HBB Protein, hemoglobin, beta

HBB

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HBB

Official Full Name hemoglobin, beta
Background The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3.
Synonyms HBB; hemoglobin, beta; hemoglobin subunit beta; beta globin; CD113t C; HBD; beta globin chain; hemoglobin beta chain; CD113t-C; beta-globin
    • Species :
    • Cattle
    • Cynomolgus Monkey
    • Horse
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Sheep
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human plasma
    • Mammalian Cell
    • Sheep
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • S
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HBB-001H Native Human Hemoglobin S, Ferrous Stabilized Human plasma N/A
    Human HBB-01H Recombinant Human HBB Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HBB-094H Recombinant Human HBB Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human HBB-13679H Recombinant Human HBB, GST-tagged E.coli GST
    Human HBB-4596H Recombinant Human HBB Protein, GST-tagged Wheat Germ GST
    Human HBB-5622HCL Recombinant Human HBB 293 Cell Lysate HEK293 N/A
    Human HBB-7865H Recombinant Human HBB protein, His & GST-tagged E.coli His/GST
    Mouse Hbb-7866M Recombinant Mouse Hbb protein, His & S-tagged E.coli His/S
    Rat HBB-2799R Recombinant Rat HBB Protein Mammalian Cell His
    Cynomolgus Monkey HBB-585C Recombinant Cynomolgus HBB Protein, His-tagged Mammalian Cell His
    Rhesus Macaque HBB-2041R Recombinant Rhesus monkey HBB Protein, His-tagged Mammalian Cell His
    Sheep HBb-49S Native Sheep Hemoglobin Beta (HBb) Protein Sheep N/A
    Cattle HBB-7862C Recombinant Cattle HBB protein, His & T7-tagged E.coli His/T7
    Horse HBB-7863H Recombinant Horse HBB protein, His & T7-tagged E.coli His/T7
    Sheep HBB-7867S Recombinant Sheep HBB protein, His-tagged E.coli His

    HBB involved in several pathways and played different roles in them. We selected most pathways HBB participated on our site, such as African trypanosomiasis, Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with HBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    African trypanosomiasis PLCB3; GNAQ; IDO1; TLR9; PLCB1; IFNG; FAS; IL18; APOL1; IL1B
    Malaria HBB-B1; THBS1; THBS3; CD81; ITGB2L; SDC1; IL1B; LRP1; TLR9; COMP

    HBB has several biochemical functions, for example, contributes_to haptoglobin binding, heme binding, hemoglobin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HBB itself. We selected most functions HBB had, and list some proteins which have the same functions with HBB. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to haptoglobin binding HBA2; HBB; HBA-A2; HBA1
    heme binding HBAA; FA2H; CYP46A1.2; CYP1C2; CYP2D6; CYP4V2; CBS; CYP4A12A; CYP2K18; DGCR8
    hemoglobin binding LRP2; HPR; HP; HBB; AHSP; CUBN
    iron ion binding P3H2; CYP2A7; CH25HL2; LEPREL2; CYP2X7; PPEF1; P4HA3; TPH1; ALOX5A; CYP1B1
    oxygen binding CYP3A7; CYP2J6; CYP1A4; CYP2D26; CYP2C39; HBG1; CYP2C70; CYP2F2; CYP2J5; CYP2K19
    oxygen transporter activity CYGB; BA1; HBG2; HBM; HBA-X; HBBE2; HBBE1.1; HBE; HBG1; NGB
    contributes_to peroxidase activity HBA-A2; HBA1; HBB; HBA2
    protein binding POP5; PHF10; FHOD1; SAC3D1; PRKRIR; CAMKK1; PBRM1; TACR2; ASB9; NDP

    HBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HBB here. Most of them are supplied by our site. Hope this information will be useful for your research of HBB.

    HBA1

    Bao, WL; Zhong, H; et al. Immunologic characterization suggests reduced alloimmunization in a murine model of thalassemia intermedia. TRANSFUSION 54:2880-2891(2014).
    Afridi, S; Atkinson, A; et al. Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso. MALARIA JOURNAL 11:-(2012).

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