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HBB

  • Official Full Name

    hemoglobin, beta

  • Overview

    The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3.
  • Synonyms

    HBB; hemoglobin, beta; hemoglobin subunit beta; beta globin; CD113t C; HBD; beta globin chain; hemoglobin beta chain; CD113t-C; beta-globin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Cynomolgus Monkey
  • Horse
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Sheep
  • E.coli
  • HEK293
  • HEK293T
  • Human plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sheep
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HBB-7865H Recombinant Human HBB protein, His & GST-tagged E.coli His/GST Met1~His147 (Accession # P68871)
Human HBB-13679H Recombinant Human HBB, GST-tagged E.coli GST 1-147a.a.
Human HBB-4596H Recombinant Human HBB Protein, GST-tagged Wheat Germ GST
Human HBB-5622HCL Recombinant Human HBB 293 Cell Lysate HEK293 N/A
Human HBB-01H Recombinant Human HBB Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human HBB-3491HF Recombinant Full Length Human HBB Protein, GST-tagged In Vitro Cell Free System GST 147 amino acids
Human HBB-001H Native Human Hemoglobin S, Ferrous Stabilized Human plasma N/A
Human HBB-181HFL Recombinant Full Length Human HBB Protein, C-Flag-tagged Mammalian cells Flag
Human HBB-094H Recombinant Human HBB Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human HBB-1047H Recombinant Human HBB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HBB-059H Recombinant Human HBB Mutant (T87Q) Protein, Myc/DDK-tagged HEK293 Myc/DDK
Human HBB-1047H-B Recombinant Human HBB Protein Pre-coupled Magnetic Beads HEK293
Human HBB-2441H Recombinant Human HBB Protein (Met1-His147), N-His tagged E.coli N-His Met1-His147
Mouse Hbb-7866M Recombinant Mouse Hbb protein, His & S-tagged E.coli His/S Met1~His147 (Accession # P02088)
Rat HBB-2799R Recombinant Rat HBB Protein Mammalian Cell His
Rat HBB-2454R-B Recombinant Rat HBB Protein Pre-coupled Magnetic Beads HEK293
Rat HBB-2454R Recombinant Rat HBB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle HBB-7862C Recombinant Cattle HBB protein, His & T7-tagged E.coli His/T7 Met1~His145 (Accession # P02070)
Cynomolgus Monkey HBB-585C Recombinant Cynomolgus HBB Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey HBB-331C Recombinant Cynomolgus Monkey HBB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey HBB-331C-B Recombinant Cynomolgus Monkey HBB Protein Pre-coupled Magnetic Beads HEK293
Horse HBB-7863H Recombinant Horse HBB protein, His & T7-tagged E.coli His/T7 Met1~His147 (Accession # P02062)
Rhesus Macaque HBB-2041R Recombinant Rhesus monkey HBB Protein, His-tagged Mammalian Cell His
Rhesus Macaque HBB-1862R Recombinant Rhesus Macaque HBB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HBB-1862R-B Recombinant Rhesus Macaque HBB Protein Pre-coupled Magnetic Beads HEK293
Sheep HBB-7867S Recombinant Sheep HBB protein, His-tagged E.coli His Met1~His145
Sheep HBb-49S Native Sheep Hemoglobin Beta (HBb) Protein Sheep N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HBB Related Articles

HBB involved in several pathways and played different roles in them. We selected most pathways HBB participated on our site, such as African trypanosomiasis, Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with HBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
African trypanosomiasisPRKCA;APOL1;IL12A;MYD88;IDO1;FAS;APOA1;IL12B;HBB-B1
MalariaITGAL;HBA-A2;HBA1;GYPC;SELP;VCAM1;IL-8;IL6;IL18

HBB has several biochemical functions, for example, contributes_to haptoglobin binding, heme binding, hemoglobin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HBB itself. We selected most functions HBB had, and list some proteins which have the same functions with HBB. You can find most of the proteins on our site.

Function Related Protein
contributes_to haptoglobin bindingHBA1;HBB;HBA-A2;HBA2
heme bindingFECH;MB;NENF;CYP2P8;CYP24A1;CYP1A2;LPO;CYP19A1;CYP17A2
hemoglobin bindingLRP2;HPR;HP;AHSP;CUBN;HBB
iron ion bindingTPH1A;CYP3A4;NDOR1;FAM125B;CYP2K19;CYP24A1;Scd1;CYP2B6;NOS2B
oxygen bindingCYP2K16;HBAE1;HBAD;CYP2F1;CYP2N13;HBB-BH1;CYP2K22;CYP2P7;CYP2J6
oxygen transporter activityHBAE3;CYGB;HBE1;HBAA1;HBA2;HBQ1;HBG1;HBBE2;HBAD
contributes_to peroxidase activityHBB;HBA-A2;HBA2;HBA1
protein bindingMT1G;C12orf5;GPR19;ZWILCH;EIF4B;FAM58A;DOCK4;LRP12;RASA1

HBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HBB here. Most of them are supplied by our site. Hope this information will be useful for your research of HBB.

HBA1

Bao, WL; Zhong, H; et al. Immunologic characterization suggests reduced alloimmunization in a murine model of thalassemia intermedia. TRANSFUSION 54:2880-2891(2014).
Afridi, S; Atkinson, A; et al. Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso. MALARIA JOURNAL 11:-(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary function of HBB in blood and oxygen transport? 02/27/2022

HBB, part of the hemoglobin molecule, is crucial for oxygen transport in the blood.

What potential therapeutic approaches target HBB gene mutations in blood disorders? 07/29/2020

Therapies targeting HBB mutations aim to correct or compensate for the defective hemoglobin in blood disorders.

How do mutations in the HBB gene affect its protein product and lead to disease? 07/28/2020

HBB mutations can lead to abnormal hemoglobin, resulting in impaired oxygen transport and cell damage.

How does HBB contribute to the structure and function of hemoglobin? 06/27/2018

It forms part of hemoglobin's structure, binding oxygen in red blood cells.

What is the impact of altered HBB expression on oxygen delivery and overall health? 05/24/2018

Altered HBB expression affects hemoglobin's efficiency, impacting oxygen delivery and health.

How does HBB interact with other components of the hemoglobin complex? 11/03/2017

HBB interacts with other hemoglobin subunits to form a functional oxygen-carrying complex.

What role does HBB play in genetic disorders like sickle cell anemia and thalassemia? 06/05/2017

Mutations in HBB cause sickle cell anemia and thalassemia, affecting hemoglobin's function.

Customer Reviews (3)

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Reviews
03/26/2022

    Helps us reach milestones. Efficient and accurate service.

    10/01/2021

      Critical for success. Trusted for precise protein analysis.

      04/28/2021

        Supports groundbreaking discoveries. Highly recommended for research.

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