hdac8
Share
  • Official Full Name
  • histone deacetylase 8
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Synonyms
  • HDAC8; histone deacetylase 8; HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; Wilson-Turner syndrome (mental retardation, X-linked, syndromic-6, with gynecomastia and obesity);
Cat.#:HDAC8-314HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HDAC8 Protein
+Inquiry
Cat.#:HDAC8-4650HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC8 Protein, GST-tagged
+Inquiry
Cat.#:HDAC8-1595HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 8, His-tagged
+Inquiry
Cat.#:HDAC8-1655HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 8
+Inquiry
Cat.#:HDAC8-13711HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC8, His-tagged
+Inquiry
Cat.#:HDAC8-27529THTag:His
Source (Host):Species:Human
Product nameRecombinant Human HDAC8, His-tagged
+Inquiry
Cat.#:HDAC8-3331HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC8, GST tagged
+Inquiry
Cat.#:HDAC8-335HTag:Met/His
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC8, Met&His-tagged
+Inquiry
Cat.#:HDAC8-399HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 8, GST-tagged
+Inquiry
Cat.#:HDAC8-759HTag:His
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Histone Deacetylase 8, His-tagged
+Inquiry
Cat.#:HDAC8-99HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC8 Protein, His-tagged
+Inquiry
Cat.#:Hdac8-1808MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Hdac8, His tagged
+Inquiry
Cat.#:HDAC8-2818RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HDAC8 Protein
+Inquiry
Cat.#:HDAC8-12602ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HDAC8
+Inquiry
Cat.#:HDAC8-691HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC8 cell lysate
+Inquiry
Cat.#:HDAC8-537MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC8 cell lysate
+Inquiry
Cat.#:Kit-1744Tag:
Source (Host):Species:
Product nameHDAC8 Fluorogenic Assay Kit
+Inquiry
Cat.#:Kit-2253Tag:
Source (Host):Species:
Product nameHDAC8 Activity Fluorometric Assay Kit
+Inquiry
Cat.#:Kit-1961Tag:
Source (Host):Species:
Product nameHDAC8 Inhibitor Screening Assay Kit
+Inquiry

Involved Pathway

HDAC8 involved in several pathways and played different roles in them. We selected most pathways HDAC8 participated on our site, such as Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
PPP1CC; HIST1H2BC; SLC6A3; HIST1H2AN; GNG13; CAMKK1; DDC; HIST1H2AG; HIST1H2AB; HDAC7
Viral carcinogenesis
HIST1H2BI; EGR3; GTF2A1; STAT3; HIST1H4F; MAPK3; PKM; CCND1; C3; HDAC7

Protein Function

HDAC8 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), histone deacetylase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC8 itself. We selected most functions HDAC8 had, and list some proteins which have the same functions with HDAC8. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC9B; HDAC3; HDAC1; HDAC11; HDAC6; HDAC9; HDAC7A; HDAC8; HDAC4; HDAC10
Function histone deacetylase activity
Related Protein HDAC9B; ATXN3L; SIRT1; HDAC3; SIRT2; MTA2; HDAC9; NACC2; HDAC6; HDAC4
Function metal ion binding
Related Protein ZIC6; PSMD14; THAP5; ZKSCAN1; ZNF213; CYP2P8; ZBTB12; MCEE; PVALB8; AEBP2
Function transcription factor binding
Related Protein THRA; RB1; KAT8; FOXF2; GTF2B; PER1; MED1; KAT2B; POU5F1; TFDP1A

Interacting Protein

HDAC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC8.
TP53; STAT3; bmf_human_gene; SEC16A; CPNE3; SVIL; TPM3; MME; NUP98; TPM4; SMC1A; CROCC; ZSCAN2; STAG2; MDM1; CHCHD3; ADD3; SMC3