Recombinant Full Length Rat HDAC8 Protein, C-His-tagged

• Cat.No.: HDAC8-13RFL
• Product Overview: Recombinant Full Length Rat HDAC8 Protein, fused to His-tag at C-terminus, was expressed in E. coli.

Specification

• Description: Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of macromolecule metabolic process; and negative regulation of osteoblast differentiation. Located in nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).
• Source: E. coli
• Species: Rat
• Tag: C-His
• Form: Sterile 50mM Tris, 200mM NaCl, pH 8.0.
• Molecular Mass: 43 kDa
• AA Sequence: MEIPEEPANSGHSLPPVYIYSPEYV SICDSLVKVPKRASMVHSLIEAYAL HKQMRIVKPKVASMEEMATFHTDAY LQHLQKVSQEGDEDHPDSIEYGLGY DCPATEGIFDYAAAIGGGTITAAQC LIDGKCKVAINWSGGWHHAKKDEAS GFCYLNDAVLGILRLRRKFDRILYV DLDLHHGDGVEDAFSFTSKVMTVSL HKFSPGFFPGTGDMSDVGLGKGRYY SVNVPIQDGIQDEKYYHICESVLKE VYQAFNPKAVVLQLGADTIAGDPMC SFNMTPVGIGKCLKYVLQWQLATLI LGGGGYNLANTARCWTYLTGVILGK TLSSEIPDHEFFTAYGPDYVLEITP SCRPDRNEPHRIQQILNYIKGNLKH VVHHHHHHHHHH
• Purity: >90% by SDS-PAGE.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.18mg/ml by BCA.

Gene Information

• Gene Name: Hdac8 histone deacetylase 8 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: HDAC8
• Synonyms: HDAC8; histone deacetylase 8; HD8; RGD1562895
• Gene ID: 363481
• mRNA Refseq: NM_001126373.2
• Protein Refseq: NP_001119845.2
• UniProt ID: B1WC68