Active Recombinant Full Length Human Histone Deacetylase 8, His-tagged

• Cat.No.: HDAC8-1595H
• Product Overview: Full-length recombinant human HDAC8 was expressed by baculovirus in Sf9 insect cells using a C-terminal His tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Protein Length: 1-377aa
• Description: HDAC8 or Histone deacetylase 8 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. The protein encoded by this gene belongs to class I of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors.
• Applications: HDAC Assay; Western Blot
• Molecular Weight: 47 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM MOPS, PH 7.0, 300 mM NaCI, 150 mM imidazole, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: >90%
• Concentration: 0.05 ug/ul
• Specific Activity: 1400 RLU/min/ng
• Sequences: Full length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class I

Gene Information

• Gene Name: HDAC8 histone deacetylase 8 [ Homo sapiens ]
• Official Symbol: HDAC8
• Synonyms: HDAC8; histone deacetylase 8; HD8; RPD3; CDA07; HDACL1; histone deacetylase 8; OTTHUMP00000023539; OTTHUMP00000023540; OTTHUMP00000023541; OTTHUMP00000023542; OTTHUMP00000023543; OTTHUMP00000023544; OTTHUMP00000023545; OTTHUMP00000023546; OTTHUMP00000023549; histone deacetylase-like 1
• Gene ID: 55869
• mRNA Refseq: NM_001166418
• Protein Refseq: NP_001159890
• MIM: 300269
• UniProt ID: Q9BY41
• Chromosome Location: Xq13
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; metal ion binding; histone deacetylase activity