Recombinant Human HDAC8 Protein, His-tagged HDAC8-26H

Recombinant Human HDAC8 Protein, His-tagged

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Recombinant Human HDAC8 Protein, His-tagged

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Cat.No. : HDAC8-26H
Product Overview : Recombinant human HDAC8(2-377) protein with a C-terminal His-tag was expressed in E. coli.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 45.3 kDa
Protein length : 2-377
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 nmol/min acetate from 100 μM acetylated p53 peptide at 37 centigrade in 25 mM Tris, pH 8.0, 137 mM NaCl, 2.7 mM KCl, and 1 mM MgCl2.
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 50 mM Tris, pH 7.5, with 200 mM sodium chloride 2.5 mM potassium chloride, 1 mM TCEP, 25% glycerol
SDS-PAGE Analysis of HDAC8 :

Lane 1: MW Markers; Lane 2: HDAC8 (2 μg); Lane 3: HDAC8 (4 μg). Representative gel image shown; actual purity may vary between each batch.

Figure :

HDAC8 activity was inhibited by a known inhibit Trichostatin A.

Gene Name : HDAC8 histone deacetylase 8 [ Homo sapiens (human) ]
Official Symbol : HDAC8
Synonyms : HDAC8; histone deacetylase 8; HD8; WTS; RPD3; CDA07; CDLS5; KDAC8; MRXS6; HDACL1; histone deacetylase 8; histone deacetylase-like 1
Gene ID : 55869
mRNA Refseq : NM_001166418
Protein Refseq : NP_001159890
MIM : 300269
UniProt ID : Q9BY41

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