Recombinant Human HDAC8 Protein, His-tagged


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Recombinant Human HDAC8 Protein, His-tagged

HDAC8 Related Products

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Cat.No. : HDAC8-26H
Product Overview : Recombinant human HDAC8(2-377) protein with a C-terminal His-tag was expressed in E. coli.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 45.3 kDa
Protein length : 2-377
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 nmol/min acetate from 100 μM acetylated p53 peptide at 37 centigrade in 25 mM Tris, pH 8.0, 137 mM NaCl, 2.7 mM KCl, and 1 mM MgCl2.
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 50 mM Tris, pH 7.5, with 200 mM sodium chloride 2.5 mM potassium chloride, 1 mM TCEP, 25% glycerol
SDS-PAGE Analysis of HDAC8 :

Lane 1: MW Markers; Lane 2: HDAC8 (2 μg); Lane 3: HDAC8 (4 μg). Representative gel image shown; actual purity may vary between each batch.

Figure :

HDAC8 activity was inhibited by a known inhibit Trichostatin A.

Gene Name : HDAC8 histone deacetylase 8 [ Homo sapiens (human) ]
Official Symbol : HDAC8
Synonyms : HDAC8; histone deacetylase 8; HD8; WTS; RPD3; CDA07; CDLS5; KDAC8; MRXS6; HDACL1; histone deacetylase 8; histone deacetylase-like 1
Gene ID : 55869
mRNA Refseq : NM_001166418
Protein Refseq : NP_001159890
MIM : 300269
UniProt ID : Q9BY41
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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