hmbs
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  • Official Full Name
  • hydroxymethylbilane synthase
  • Background
  • This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  • Synonyms
  • HMBS; hydroxymethylbilane synthase; PBGD, PORC, porphobilinogen deaminase , porphyria, acute; Chester type , UPS, uroporphyrinogen I synthase; porphobilinogen deaminase; HEM3_HUMAN; PBG D; PBG-D; PBGD; Pre uroporphyrinogen synthase; Pre-uroporphyrinogen synthase; UPS; Uroporphyrinogen I synthase; Uroporphyrinogen I synthetase; OTTHUMP00000238530; OTTHUMP00000238532; OTTHUMP00000238533; OTTHUMP00000238534; OTTHUMP00000238537; OTTHUMP00000238539; OTTHUMP00000238540; OTTHUMP00000238541; OTTHUMP00000238580; PORC; EC 2.5.1.61
Cat.#:HMBS-4856HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HMBS Protein, GST-tagged
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Cat.#:HMBS-1929HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Hydroxymethylbilane Synthase, His-tagged
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Cat.#:HMBS-13835HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMBS, GST-tagged
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Cat.#:HMBS-29326THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HMBS
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Cat.#:HMBS-39HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human HMBS protein, His-tagged
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Cat.#:HMBS-2105RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HMBS Protein, His-tagged
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Cat.#:HMBS-5483HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HMBS 293 Cell Lysate
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Cat.#:HMBS-5484HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HMBS 293 Cell Lysate
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Cat.#:CBCRY24Tag:N/A
Source (Host):E. coliSpecies:
Product namePorphobilinogen deaminase
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