HMGCR Protein, 3-hydroxy-3-methylglutaryl-CoA reductase


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Official Full Name 3-hydroxy-3-methylglutaryl-CoA reductase
Background HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; 3 hydroxy 3 methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl CoA reductase; 3H3M; MGC103269; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Red; hydroxymethylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); LDLCQ3
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HMGCR-016H Recombinant Human HMGCR Protein, GST-tagged E.coli GST
    Mouse HMGCR-2377M Recombinant Mouse HMGCR Protein (700-860 aa), His-tagged E.coli His
    Human HMGCR-669H Recombinant Human HMGCR Protein (Ser426-Ala888), His-tagged Insect Cell His
    Human HMGCR-19H Recombinant Human HMGCR protein, GST-tagged Wheat Germ GST
    Human HMGCR-20H Recombinant Human HMGCR protein, GST-tagged E.coli GST
    Human HMGCR-231H Recombinant Human HMGCR Mammalian Cell His
    Human HMGCR-263H Recombinant Human HMGCR protein, His-tagged E.coli His
    Human HMGCR-802HCL Recombinant Human HMGCR cell lysate N/A
    Mouse HMGCR-7734M Recombinant Mouse HMGCR Protein Mammalian Cell His
    Rat HMGCR-2868R Recombinant Rat HMGCR Protein Mammalian Cell His
    Rat Hmgcr-8170R Recombinant Rat Hmgcr protein, His-tagged E.coli His
    Chicken HMGCR-6055C Recombinant Chicken HMGCR Mammalian Cell His

    HMGCR involved in several pathways and played different roles in them. We selected most pathways HMGCR participated on our site, such as Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Terpenoid backbone biosynthesis PDSS2; HMGCR; DHDDS; PDSS1; ICMT; HMGCS2; MVD; ACAT2; IDI2; GGPS1
    Metabolic pathways PTGS2; SAT1A.2; GFPT2; CYP3A5; HYAL1; POLR2J2; NDST4; MCCC2; PLD1A; BCMO1
    AMPK signaling pathway FOXO1; IGF1R; PRKAG3; PPP2R2A; LEPR; SREBF1; PPP2R2B; INS2; PIK3R5; MTOR
    Bile secretion SLC2A1; NCEH1; AQP9; SLCO1A5; AQP4; ABCC3; EPHX1; OSTA; PRKACB; Abcb1b

    HMGCR has several biochemical functions, for example, NADPH binding, coenzyme binding, hydroxymethylglutaryl-CoA reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCR itself. We selected most functions HMGCR had, and list some proteins which have the same functions with HMGCR. You can find most of the proteins on our site.

    Function Related Protein
    hydroxymethylglutaryl-CoA reductase (NADPH) activity HMGCRA; HMGCR; HMGCRB
    hydroxymethylglutaryl-CoA reductase activity HMGCRB; HMGCRA; HMGCR
    protein binding DAPK3; MED25; USP1; DPH2; HMGB3; EFHC2; VDR; CITED2; KLK6; RAD52
    protein homodimerization activity ADRA2C; PRPS1L1; XBP1; CUL3; DGAT2; MUC13; ATPIF1A; IRAK1; RPE; GDF7
    protein phosphatase 2A binding ENSA; SMG5; STRN; BCL2; MASTL; AKT1; CTTNBP2NL; MAPT; PPP2R2A; IGBP1

    HMGCR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCR here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCR.

    UBIAD1; q99ib8-pro_0000045602; STARD13; UBIAD1

    Luo, YB; Mastaglia, FL; et al. Dermatomyositis, polymyositis and immune-mediated necrotising myopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:622-632(2015).
    Watanabe, Y; Suzuki, S; et al. Statins and Myotoxic Effects Associated With Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies An Observational Study in Japan. MEDICINE 94:-(2015).

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