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HMGCR

  • Official Full Name

    3-hydroxy-3-methylglutaryl-CoA reductase

  • Overview

    HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; 3 hydroxy 3 methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl CoA reductase; 3H3M; MGC103269; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Red; hydroxymethylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); LDLCQ3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HMGCR-263H Active Recombinant Human HMGCR protein, His-tagged E.coli His
Human HMGCR-231H Recombinant Human HMGCR Mammalian Cell His
Human HMGCR-19H Recombinant Human HMGCR protein, GST-tagged Wheat Germ GST
Human HMGCR-20H Recombinant Human HMGCR protein, GST-tagged E.coli GST
Human HMGCR-802HCL Recombinant Human HMGCR cell lysate N/A
Human HMGCR-669H Recombinant Human HMGCR Protein (Ser426-Ala888), His-tagged Insect Cell His Ser426-Ala888
Human HMGCR-016H Recombinant Human HMGCR Protein, GST-tagged E.coli GST 426-888
Human HMGCR-2563H Recombinant Human HMGCR Protein (Glu441-Asn875), N-SUMO tagged E.coli N-SUMO Glu441-Asn875
Human HMGCR-3039H Recombinant Human HMGCR protein, His-tagged E.coli His 588-887aa
Human HMGCR-028H Recombinant Human HMGCR Protein, GST-tagged E. coli GST 426-888
Human HMGCR-3114H-B Recombinant Human HMGCR Protein Pre-coupled Magnetic Beads HEK293
Human HMGCR-3114H Recombinant Human HMGCR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HMGCR-7734M Recombinant Mouse HMGCR Protein Mammalian Cell His
Mouse HMGCR-4241M Recombinant Mouse HMGCR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HMGCR-4241M-B Recombinant Mouse HMGCR Protein Pre-coupled Magnetic Beads HEK293
Mouse HMGCR-2377M Recombinant Mouse HMGCR Protein (700-860 aa), His-tagged E.coli His 700-860 aa
Rat HMGCR-2868R Recombinant Rat HMGCR Protein Mammalian Cell His
Rat Hmgcr-8170R Recombinant Rat Hmgcr protein, His-tagged E.coli His Ala638~Ala887
Rat HMGCR-2523R Recombinant Rat HMGCR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HMGCR-2523R-B Recombinant Rat HMGCR Protein Pre-coupled Magnetic Beads HEK293
Chicken HMGCR-6055C Recombinant Chicken HMGCR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HMGCR Related Articles
  • HMGCR Related Research Area

HMGCR involved in several pathways and played different roles in them. We selected most pathways HMGCR participated on our site, such as Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Terpenoid backbone biosynthesisZMPSTE24;FNTB;HMGCS1;IDI2;HMGCRA;HMGCR;PCYOX1;FNTA;MVD
Metabolic pathwaysCOX6A1;CYP2C37;TPH1B;MCAT;GALNT18A;PLA2G2D;MAN1C1;APRT;GANAB
AMPK signaling pathwayIRS2;PPP2R2B;AKT1S1;ADIPOR2;TSC2;PPP2R5E;CREB3L1;PPP2CA;PCK1
Bile secretionPRKACG;ATP1B2;ATP1A1;SLC4A4;RXRA;SLC9A1;ATP1B4;CYP3A4;SLC22A7

HMGCR has several biochemical functions, for example, NADPH binding, coenzyme binding, hydroxymethylglutaryl-CoA reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCR itself. We selected most functions HMGCR had, and list some proteins which have the same functions with HMGCR. You can find most of the proteins on our site.

Function Related Protein
NADPH bindingGRHPR;TP53I3;MTRR;FASN;CBR4;CBR3;DHFR;CRYZ;DECR1
coenzyme bindingHMGCRA;WWOX;ACAT1;TSTA3;ALAS2;GCH1;ATAT1;HMGCRB;QDPRB1
hydroxymethylglutaryl-CoA reductase (NADPH) activityHMGCRA;HMGCRB;HMGCR
hydroxymethylglutaryl-CoA reductase activityHMGCR;HMGCRB;HMGCRA
protein bindingZEB1;PTPRA;TRAIP;EIF4E2;LRIF1;DUT;CRNKL1;SHC4;CXCR5
protein homodimerization activityUGT1A4;VEGFA;TIGIT;IRAK1;MYOM1;ODZ4;HMGCS1;KCNK9;GDF6
protein phosphatase 2A bindingIGBP1;SMG7;PTPN1;STRN4;GRIN3A;SPHK1;STRN;MASTL;CTTNBP2NL

HMGCR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCR here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCR.

UBIAD1; q99ib8-pro_0000045602; STARD13; UBIAD1

Luo, YB; Mastaglia, FL; et al. Dermatomyositis, polymyositis and immune-mediated necrotising myopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:622-632(2015).
Watanabe, Y; Suzuki, S; et al. Statins and Myotoxic Effects Associated With Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies An Observational Study in Japan. MEDICINE 94:-(2015).
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