Recombinant Human HMGCR Protein, GST-tagged HMGCR-016H

Recombinant Human HMGCR Protein, GST-tagged

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Recombinant Human HMGCR Protein, GST-tagged

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Cat.No. : HMGCR-016H
Product Overview : Recombinant Human HMGCR protein (426-888) with a N-terminal GST-tag was expressed in E.coli
Description : HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : GST
Molecular Mass : 76.5 kDa
Protein length : 426-888
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to convert 1 µmol of NADPH to NADP + per minute at 37 centigrade in 20 mM sodium phosphate, pH 6.5, 100 mM sodium chloride, and 10 mM DTT, containing 300 µM (R,S)-HMG-CoA and 300 µM NADPH.
Stability : ≥ 2 years
Storage : -80 centigrade
Storage Buffer : 50 mM Tris, pH 8.0, with 300 mM sodium chloride and 20% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
SDS-PAGE Analysis of HMGCR :

Lane 1: MW Markers
Lane 2: HMG-CoA Reductase (2 µg)
Lane 3: HMG-CoA Reductase (4 µg)

Gene Name : HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [ Homo sapiens (human) ]
Official Symbol : HMGCR
Synonyms : HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; LDLCQ3; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; EC 1.1.1.34
Gene ID : 3156
mRNA Refseq : NM_000859
Protein Refseq : NP_000850
MIM : 142910
UniProt ID : P04035

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