Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human HMGCR Protein, GST-tagged

Cat.No. : HMGCR-028H
Product Overview : Recombinant N-terminal GST-tagged human HMGCR protein (426-888) was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : GST
Molecular Mass : 76.5 kDa
Protein length : 426-888
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to convert 1 μmol of NADPH to NADP+ per minute at 37 centigrade in 20 mM sodium phosphate, pH 6.5, 100 mM sodium chloride, and 10 mM DTT, containing 300 μM (R,S)-HMG-CoA and 300 μM NADPH.
Stability : ≥ 6 months
Storage : At -80 centigrade.
Storage Buffer : 50 mM Tris, pH 8.0, with 300 mM sodium chloride and 20% glycerol
Gene Name : HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [ Homo sapiens (human) ]
Official Symbol : HMGCR
Synonyms : HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; LDLCQ3; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; EC 1.1.1.34
Gene ID : 3156
mRNA Refseq : NM_000859
Protein Refseq : NP_000850
MIM : 142910
UniProt ID : P04035

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All HMGCR Products

Required fields are marked with *

My Review for All HMGCR Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends