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HNMT

  • Official Full Name

    histamine N-methyltransferase

  • Overview

    In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
  • Synonyms

    HNMT; histamine N-methyltransferase; HMT; HNMT-S1; HNMT-S2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Rat Kidney
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HNMT-22H Active Recombinant Human HNMT protein, His-tagged E.coli His
Human HNMT-13863H Recombinant Human HNMT, His-tagged E.coli His 1-292a.a.
Human HNMT-1704H Recombinant Human Histamine N-Methyltransferase, His-tagged Human His
Human HNMT-4898H Recombinant Human HNMT Protein, GST-tagged Wheat Germ GST
Human HNMT-27547TH Recombinant Human HNMT N/A
Human HNMT-1811H Recombinant Human HNMT protein, GST-tagged E.coli GST Met1-Ala292
Human HNMT-5455HCL Recombinant Human HNMT 293 Cell Lysate HEK293 N/A
Human HNMT-3677HF Recombinant Full Length Human HNMT Protein, GST-tagged In Vitro Cell Free System GST 51 amino acids
Rat HNMT-1355R Active Native Rat HNMT Protein Rat Kidney N/A
Rat HNMT-2878R Recombinant Rat HNMT Protein Mammalian Cell His
Rat HNMT-2533R-B Recombinant Rat HNMT Protein Pre-coupled Magnetic Beads HEK293
Rat HNMT-2533R Recombinant Rat HNMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HNMT-2116R Recombinant Rhesus monkey HNMT Protein, His-tagged Mammalian Cell His
Rhesus Macaque HNMT-1937R Recombinant Rhesus Macaque HNMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HNMT-1937R-B Recombinant Rhesus Macaque HNMT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HNMT-1058Z Recombinant Zebrafish HNMT Mammalian Cell His
Chicken HNMT-5216C Recombinant Chicken HNMT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HNMT Related Research Area

HNMT involved in several pathways and played different roles in them. We selected most pathways HNMT participated on our site, such as Histidine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Histidine metabolismMAOA;FTCD;ALDH2;CNDP1;ALDH9A1;ASPA;ALDH3A2;ALDH2.2;ALDH9A1B

HNMT has several biochemical functions, for example, histamine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNMT itself. We selected most functions HNMT had, and list some proteins which have the same functions with HNMT. You can find most of the proteins on our site.

Function Related Protein
histamine N-methyltransferase activity

HNMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNMT here. Most of them are supplied by our site. Hope this information will be useful for your research of HNMT.

TERF1; CAMK2D; TINF2; POT1; Tpm1

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is there a link between HNMT and gastrointestinal disorders? 03/21/2021

Yes, HNMT dysfunction has been associated with gastrointestinal disorders, and understanding its role may open avenues for novel therapeutic strategies.

In what ways does HNMT play a role in the nervous system? 10/23/2017

HNMT is involved in the inactivation of histamine in the central nervous system, influencing neurotransmission and potentially impacting conditions like schizophrenia and anxiety disorders.

Can HNMT be used as a predictive marker for treatment response in certain conditions? 04/05/2017

Research is underway to investigate whether HNMT levels or activity could serve as predictive markers for treatment response in conditions where histamine regulation is implicated.

How does HNMT relate to drug metabolism and interactions? 01/14/2017

HNMT is involved in the metabolism of certain drugs, and variations in its activity can influence drug responses and potential interactions.

Can HNMT be a target for cancer therapy? 01/05/2017

Some studies suggest that HNMT may play a role in certain cancers, making it a potential target for therapeutic interventions. However, more research is needed in this area.

Customer Reviews (3)

Write a review
Reviews
03/21/2018

    HNMT protein has been extensively studied and characterized, allowing researchers to confidently integrate it into their experimental workflows.

    01/17/2018

      Its unique properties and functions make it an essential component in investigating various biological processes and molecular mechanisms.

      02/26/2017

        Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the HNMT protein.

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