hprt1
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  • Official Full Name
  • hypoxanthine phosphoribosyltransferase 1
  • Background
  • The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate;and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl;1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage;pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
  • Synonyms
  • HPRT1; hypoxanthine phosphoribosyltransferase 1; HPRT; hypoxanthine-guanine phosphoribosyltransferase; HGPRT; Lesch Nyhan syndrome; HGPRTase; HPRT 1; HPRT_HUMAN; Hypoxanthine guanine phosphoribosyltransferase; Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)
Cat.#:HPRT1-5011HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HPRT1 Protein, GST-tagged
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Cat.#:HPRT1-1796HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Hypoxanthine Phosphoribosyltransferase 1, His-tagged
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Cat.#:HPRT1-28755THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HPRT1, His-tagged
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Cat.#:HPRT1-2905RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HPRT1 Protein
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Cat.#:HPRT1-595CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus HPRT1 Protein, His-tagged
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Cat.#:HPRT1-6411CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HPRT1
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Cat.#:HPRT1-12230ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HPRT1
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Cat.#:HPRT1-5398HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HPRT1 293 Cell Lysate
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Involved Pathway

HPRT1 involved in several pathways and played different roles in them. We selected most pathways HPRT1 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
POLR2L; POLR2EB; POLR1A; PRPS1; PKM2; PAPSS2A; IMPDH1B; CECR1; RRM1; CANT1
Drug metabolism - other enzymes
TK1; CES1D; UCK2; ITPA; UGT1A6A; UGT5G1; UGT2B15; Ces2c; UGT1A6; CYP2A6
Metabolic pathways
ACSL4A; NDST1; AMY2A2; BPNT1; PYCRL; KLF15; SQLEA; GBA2; UQCRC2; PI4KB

Protein Function

HPRT1 has several biochemical functions, for example, guanine phosphoribosyltransferase activity, hypoxanthine phosphoribosyltransferase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPRT1 itself. We selected most functions HPRT1 had, and list some proteins which have the same functions with HPRT1. You can find most of the proteins on our site.
Function
Related Protein
Function guanine phosphoribosyltransferase activity
Related Protein HPRT1
Function hypoxanthine phosphoribosyltransferase activity
Related Protein HPRT1L; HPRT1
Function magnesium ion binding
Related Protein NUDT3; IRAK3; GEM; NUDT5; MAPK12; PPM1AB; ENO4; PPM1BA; STK36; IDH3B
Function nucleotide binding
Related Protein SMC2; PTK2BB; GRK1A; CAMK2D1; BSK146; TMEM63A; RBM11; RBM34; MATR3; SAFB2
Function protein binding
Related Protein CTDP1; ITGB1; EPHB4; PROP1; VEGFAA; NITR9; SEC23IP; PPP1R2P9; BLOC1S1; ZKSCAN17
Function protein homodimerization activity
Related Protein ACCS; TNNC1; MVD; LGALS1; TESC; CACYBP; FGFR1; NOD1; THRA; CDA

Interacting Protein

HPRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HPRT1.
WDYHV1; PRTFDC1; SDCBP; ISCU; EIF1B; HUS1; EPB41; MCC