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HPRT1

  • Official Full Name

    hypoxanthine phosphoribosyltransferase 1

  • Overview

    The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate;and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl;1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage;pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
  • Synonyms

    HPRT1; hypoxanthine phosphoribosyltransferase 1; HPRT; hypoxanthine-guanine phosphoribosyltransferase; HGPRT; Lesch Nyhan syndrome; HGPRTase; HPRT 1; HPRT_HUMAN; Hypoxanthine guanine phosphoribosyltransferase; Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HPRT1-28755TH Recombinant Human HPRT1, His-tagged E.coli His 218 amino acids
Human HPRT1-1796H Recombinant Human Hypoxanthine Phosphoribosyltransferase 1, His-tagged Human His
Human HPRT1-5011H Recombinant Human HPRT1 Protein, GST-tagged Wheat Germ GST
Human HPRT1-5398HCL Recombinant Human HPRT1 293 Cell Lysate HEK293 N/A
Human HPRT1-619HFL Recombinant Full Length Human HPRT1 Protein, C-Flag-tagged Mammalian cells Flag
Human HPRT1-3628HF Recombinant Full Length Human HPRT1 Protein, GST-tagged In Vitro Cell Free System GST 218 amino acids
Human HPRT1-1096H Recombinant Human HPRT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HPRT1-0321H Recombinant Human HPRT1 Protein (M1-A218), Tag Free E.coli No tag M1-A218
Human HPRT1-1096H-B Recombinant Human HPRT1 Protein Pre-coupled Magnetic Beads HEK293
Human HPRT1-0322H Recombinant Human HPRT1 Protein (M1-A218), His/Strep tagged E.coli His/Strep M1-A218
Human HPRT1-2357H Recombinant Human HPRT1 Protein (Met1-Ala218), N-His tagged E.coli N-His Met1-Ala218
Human HPRT1-5298H Recombinant Human HPRT1 protein, His-tagged E.coli His 2-218aa
Human HPRT1-2358H Recombinant Human HPRT1 Protein (Thr3-Ala218), N-GST tagged E.coli N-GST Thr3-Ala218
Mouse HPRT1-2696M Recombinant Mouse HPRT1 Protein, GST-tagged E.coli N-GST Thr3-Ala218
Rat HPRT1-2905R Recombinant Rat HPRT1 Protein Mammalian Cell His
Rat HPRT1-2560R-B Recombinant Rat HPRT1 Protein Pre-coupled Magnetic Beads HEK293
Rat HPRT1-2560R Recombinant Rat HPRT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey HPRT1-595C Recombinant Cynomolgus HPRT1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey HPRT1-341C Recombinant Cynomolgus Monkey HPRT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey HPRT1-341C-B Recombinant Cynomolgus Monkey HPRT1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HPRT1-12230Z Recombinant Zebrafish HPRT1 Mammalian Cell His
Chicken HPRT1-6411C Recombinant Chicken HPRT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HPRT1 involved in several pathways and played different roles in them. We selected most pathways HPRT1 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismAK7;POLR2I;POLR2E;NUDT5;PAICS;PKM;PDE6D;NME3;CANT1B
Drug metabolism - other enzymesUGT1A7;UMPS;CES1;TPMT;CYP2A6;UGT5G1;PNAT3;UCKL1;UPP1
Metabolic pathwaysGLUD1B;PDXK;HMBSA;SMPD5;POLR3GL;BDH1;UGT2A2;POLR1C;GLULB

HPRT1 has several biochemical functions, for example, guanine phosphoribosyltransferase activity, hypoxanthine phosphoribosyltransferase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPRT1 itself. We selected most functions HPRT1 had, and list some proteins which have the same functions with HPRT1. You can find most of the proteins on our site.

Function Related Protein
guanine phosphoribosyltransferase activity
hypoxanthine phosphoribosyltransferase activityHPRT1;HPRT1L
magnesium ion bindingIDH3G;PSPH;RPS6KA2;TSSK6;NUDT18;NUDT7;MAST4;ITPK1;PPM1BB
nucleotide bindingELAVL2;SGK2B;ABCG4B;TRIOA;CNOT4B;CRCP;CPEB1B;ARL8;NTRK2B
protein bindingPPP2CB;WDR11;HLTF;WBP1L;RTN4RL2B;BEGAIN;MXD1;CALM3;C4BP
protein homodimerization activitySQSTM1;TPD52L1;UNC13A;NOD1;PDCD6;AADAT;ECE1;QDPR;WHRN

HPRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HPRT1.

WDYHV1; PRTFDC1; SDCBP; ISCU; EIF1B; HUS1; EPB41; MCC

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