IMPDH2
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Official Full Name
IMP (inosine 5-monophosphate) dehydrogenase 2
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Overview
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. -
Synonyms
IMPDH2; IMP (inosine 5-monophosphate) dehydrogenase 2; inosine-5-monophosphate dehydrogenase 2; EC 1.1.1.205; IMDH2_HUMAN; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH II; IMPDH-II; IMPDHII; Inosine 5 monophosphate dehydrogenase 2; inosine 5 phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- IMPDH2 Related Articles
IMPDH2 involved in several pathways and played different roles in them. We selected most pathways IMPDH2 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | POLA2;PDE6G;NME2B.2;POLR2EB;ADKB;PDE1B;PGM1;PRPS1L1;ENTPD3 |
| Drug metabolism - other enzymes | UGT1A2;DPYS;TPMT.1;CES2;GUSB;IMPDH1;UGT2A1;Nat3;UMPS |
| Metabolic pathways | ATP6V1B2;LSM1;CPS1;TYRP1B;H2-KE6;PGK1;ATP5O;UGT1A6;ENOPH1 |
IMPDH2 has several biochemical functions, for example, DNA binding, IMP dehydrogenase activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPDH2 itself. We selected most functions IMPDH2 had, and list some proteins which have the same functions with IMPDH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | OTX1A;PDCD5;ERG;MCM8;DNASE1L1;MECP2;NEUROD4;DMRT3A;TGIF2 |
| IMP dehydrogenase activity | IMPDH1A;IMPDH1B;IMPDH1;IMPDH2 |
| RNA binding | RBM20;RPL30;PUF60B;DPPA5;PAPOLA;NOL4;METTL3;SRSF9;C14orf166 |
| metal ion binding | ZNF614;MLL1;ZCCHC16;ADH1;C1GALT1B;ZSCAN18;ZDHHC20A;ZNF329;ZFP12 |
| nucleotide binding | BMPR2A;RHOGD;RBM20;NLRP4E;CAMK1GB;MSI1;CCC2;RND1L;GNA15.4 |
| protein binding | C16orf48;DNM3;PASK;DAK;ZBTB9;RP9;CDK10;LNX2;MAGEH1 |
IMPDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPDH2.
APIP; RSG1; BCAR3; HLA-C; VHL; EIF6; ARF6; IKBKE; TNFRSF10D; FTSJ1; TNIK; PIAS4; UBQLN4; 15-deoxy-delta(12,14; ssrna_ag
- Q&As
- Reviews
Q&As (6)
Ask a questionThe purine metabolism related signal pathways and molecular interactions, such as AMPK pathway, GTP enzyme amp-activated protein and purine nucleotide made, etc.
It can control by a variety of factors, such as ATP, GTP, AMPK and made mTOR signaling pathways, such as active state, and other factors relating to the cell cycle and cell differentiation.
It is highly expressed in tumor cells. It is involved in the regulation of purine metabolism and nucleotide synthesis, and may play an important role in tumor cell proliferation and survival.
This protein is involved in purine metabolic pathway and is one of the key enzymes for purine nucleotide synthesis. It plays an important role in biological processes such as embryonic development and immune regulation.
It is involved in the regulation of purine metabolism and T cell activation in immune regulation, and may play an important role in the regulation of immune cell function and inflammatory response.
Can be induced by cloning and expression of of IMPDH2, applied in drug discovery and gene function research and other fields.
Customer Reviews (3)
Write a reviewI'm very satisfied. The quality is good and the price is affordable.
Good activity, can maintain long-term activity.
Very easy to use and highly recommended.
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