impdh2
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  • Official Full Name
  • IMP (inosine 5-monophosphate) dehydrogenase 2
  • Background
  • This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
  • Synonyms
  • IMPDH2; IMP (inosine 5-monophosphate) dehydrogenase 2; inosine-5-monophosphate dehydrogenase 2; EC 1.1.1.205; IMDH2_HUMAN; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH II; IMPDH-II; IMPDHII; Inosine 5 monophosphate dehydrogenase 2; inosine 5 phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II
Cat.#:IMPDH2-299HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPDH2 Protein, His-tagged
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Cat.#:IMPDH2-5138HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IMPDH2 Protein, GST-tagged
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Cat.#:IMPDH2-1274HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMP (Inosine 5'-Monophosphate) Dehydrogenase 2, His-tagged
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Cat.#:IMPDH2-1276HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IMPDH2, MYC/DDK-tagged
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Cat.#:IMPDH2-28270THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPDH2, His-tagged
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Cat.#:IMPDH2-83HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPDH2
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Cat.#:IMPDH2-8199MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IMPDH2 Protein
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Cat.#:IMPDH2-2314CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IMPDH2
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Cat.#:IMPDH2-11510ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IMPDH2
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Cat.#:IMPDH2-5210HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IMPDH2 293 Cell Lysate
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Involved Pathway

IMPDH2 involved in several pathways and played different roles in them. We selected most pathways IMPDH2 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
GC2; ADAL; AK9; NT5E; PDE5A; POLR2K; POLR2G; ADSSL; NT5C2A; ADKA
Drug metabolism - other enzymes
UMPS; IMPDH1; CDA; CES1D; CES1C; HPRT1; TYMP; UGT1A6B; NAT; TPMT.1
Metabolic pathways
CBR1; CES1C; RRM2; NFS1; CKM; ANPEPB; POLR3F; NTPCR; ATP6V0D1; FDPS

Protein Function

IMPDH2 has several biochemical functions, for example, DNA binding, IMP dehydrogenase activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPDH2 itself. We selected most functions IMPDH2 had, and list some proteins which have the same functions with IMPDH2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ASCL5; ZNF596; NR1H5; SCML1; SMG6; NANOG; HOMEZ; DMRTA2; ZNF146; MAFGB
Function IMP dehydrogenase activity
Related Protein IMPDH1B; IMPDH1; IMPDH1A; IMPDH2
Function RNA binding
Related Protein ZMAT4; PRPF40B; HNRPKL; OASL2; NSUN5B; RPL3; DDX25; SARS; DHX36; IFIT5
Function metal ion binding
Related Protein TNNC1; PAPOLB; METAP2B; ZNF329; ZNF561; ZNF41; ZDHHC18B; PNKD; SMYD1B; ZNF443
Function nucleotide binding
Related Protein AKT2L; TUBA8L; TRNAU1AP; RBFOX1L; MSI2; MARF1; FGFR1A; RHOBTB2A; CDC42L; SNRPA
Function protein binding
Related Protein SUV39H1; NRIP3; RTN4RL2B; PPP1R9A; CTSB; PYCARD; CTSZ; SYNCRIP; LRRC4B; STATH

Interacting Protein

IMPDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPDH2.
APIP; RSG1; BCAR3; HLA-C; VHL; EIF6; ARF6; IKBKE; TNFRSF10D; FTSJ1; TNIK; PIAS4; UBQLN4; 15-deoxy-delta(12,14; ssrna_ag

IMPDH2 Related Articles

Keppeke, GD; Andrade, LEC; et al. Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures. CELL AND BIOSCIENCE 5:-(2015).
Keppeke, GD; Satoh, M; et al. Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-alpha. IMMUNOLOGIC RESEARCH 60:38-49(2014).