Recombinant Human IMPDH2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: IMPDH2-4161H
• Product Overview: IMPDH2 MS Standard C13 and N15-labeled recombinant protein (NP_000875) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 55.8 kDa
• AA Sequence: MADYLISGGTSYVPDDGLTAQQLFN CGDGLTYNDFLILPGYIDFTADQVD LTSALTKKITLKTPLVSSPMDTVTE AGMAIAMALTGGIGFIHHNCTPEFQ ANEVRKVKKYEQGFITDPVVLSPKD RVRDVFEAKARHGFCGIPITDTGRM GSRLVGIISSRDIDFLKEEEHDCFL EEIMTKREDLVVAPAGITLKEANEI LQRSKKGKLPIVNEDDELVAIIART DLKKNRDYPLASKDAKKQLLCGAAI GTHEDDKYRLDLLAQAGVDVVVLDS SQGNSIFQINMIKYIKDKYPNLQVI GGNVVTAAQAKNLIDAGVDALRVGM GSGSICITQEVLACGRPQATAVYKV SEYARRFGVPVIADGGIQNVGHIAK ALALGASTVMMGSLLAATTEAPGEY FFSDGIRLKKYRGMGSLDAMDKHLS SQNRYFSEADKIKVAQGVSGAVQDK GSIHKFVPYLIAGIQHSCQDIGAKS LTQVRAMMYSGELKFEKRTSSAQVE GGVHSLHSYEKRLFTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: IMPDH2 inosine monophosphate dehydrogenase 2 [ Homo sapiens (human) ]
• Official Symbol: IMPDH2
• Synonyms: IMPDH2; IMP (inosine 5-monophosphate) dehydrogenase 2; inosine-5-monophosphate dehydrogenase 2; IMPD 2; IMPDH 2; IMP oxireductase 2; inosine 5 phosphate dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; inosine monophosphate dehydrogenase type II; IMPD2; IMPDH-II
• Gene ID: 3615
• mRNA Refseq: NM_000884
• Protein Refseq: NP_000875
• MIM: 146691
• UniProt ID: P12268