INHBA
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Official Full Name
inhibin, beta A
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Overview
Activin A is a homodimer of 14kDa beta-A. Activin A, a cytokine member of the transforming growth factor-beta superfamily, is expressed locally by the mesenchymal component of the hemopoietic microenvironment. Its expression is regulated on the mRNA level by different cytokines, and the biological activity of the protein is tightly controlled by several inhibitory molecules.1 Inhibins and activins are members of the transforming growth factor beta superfamily and are known to modulate the growth and differentiation of several cell types.2 Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. The standard product used in this kit is recombinant Activin A, which is composed of two single chains of 116 amino acids with the molecular mass of 26KDa. -
Synonyms
EDF; FRP; INHBA;
- Recombinant Proteins
- GMP Proteins
- Transfected Stable Cell Lines
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Horse
- Human
- Human/Mouse/Rat
- Mouse
- Pig
- Rat
- CHO
- E.coli
- HEK293
- HEK293F
- HEK293T
- Hi-5 Insect Cell
- Human
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Nicotiana Benthamiana
- Protein Conjugation
- Wheat Germ
- Yeast
- C
- Strep
- GST
- His
- His (Fc)
- Avi
- His(C
- ter)
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- GFP
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
INHBA involved in several pathways and played different roles in them. We selected most pathways INHBA participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with INHBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFSF8;CSH;XCL1;TNFRSF14;LEPR;IL26;IL10RA;CXCL12A;IL2RG |
| TGF-beta signaling pathway | MAPK1;INHBB;ID3;SMAD7B;BMP6;TGFBR1A;RPS6KB1;RPS6KB2;LTBP1 |
| Signaling pathways regulating pluripotency of stem cells | WNT8A;WNT8B;GRB2;WNT11;PIK3R5;SETDB1;WNT5A;FGFR4;WNT16 |
INHBA has several biochemical functions, for example, cytokine activity, growth factor activity, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INHBA itself. We selected most functions INHBA had, and list some proteins which have the same functions with INHBA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | NDP;IL36A;CCL6;ILTIFB;Ifna15;IFN-a;Il1f6;GDF9;CMTM8 |
| growth factor activity | FGF11A;MDKA;CD320;KITLG;REG1A;IL5;AGT;NUDT6;IL9 |
| hormone activity | GPHB5;PTHLHA;PRL6A1;IGF3;IGF1;PRL2C3;SMTLB;INS-IGF2;GPHA2 |
| identical protein binding | MCM10;BNIP3;MICALL1;RIPK3;TPRGL;GRB7;SH3GL1;TNK2;TRIP13 |
| inhibin binding | INHBA;INHA;IGSF1;ACVR1B;ACVR2A |
| peptide hormone binding | NPR1;GIPR;GALR1;HCRTR1;ACVR1;AGTR1B;SLC40A1;GCGR;AVPR1A |
| protein binding | CCDC93;SNF8;TBC1D10C;HMGB1;SNTB1;RGS8;ETNK1;ALKBH3;RFC4 |
| protein heterodimerization activity | HIST1H2AK;ALX1;RELA;F11R.1;SMC1A;TCF3B;UGT1A2;SMAD3;HIST1H4F |
| transforming growth factor beta receptor binding | TGFBRAP1;BMP4;GDF1;BMP15;GDF6;TGFB1A;MSTNA;GDF11;SMURF2 |
| type II activin receptor binding | INHBA;MAGI2 |
INHBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INHBA here. Most of them are supplied by our site. Hope this information will be useful for your research of INHBA.
Fst
- Q&As
- Reviews
Q&As (7)
Ask a questionINHBA is often expressed in the ovaries and testes.
INHBA is involved in the regulation of reproductive processes and cell growth.
The molecular weight is approximately 45 kDa.
INHBA is encoded by the INHBA gene.
Mutations in the INHBA gene can be linked to certain reproductive disorders.
The full name is “Inhibin subunit beta A.”
Yes, INHBA can interact with other proteins involved in cell signaling pathways.
Customer Reviews (3)
Write a reviewThe value derived from the product's usage made the investment worthwhile, considering the insights acquired.
Its reliability over time reduced the need for frequent reordering, saving both time and resources.
The product’s biocompatibility with various cell types and organisms made it versatile for a wide range of applications.
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