Recombinant Human Inhibin, Beta A

• Cat.No.: INHBA-144H
• Product Overview: RecombinantHuman Activin-A also called Activin-Beta A chain inE.Coliis a single monomeric, non-glycosylated, polypeptide chain containing 116 amino acids fragment (311-426) and having an amino-terminal hexa-histidine tag, having a total molecular weight of 17.47 kDa. The Inhibin-Beta A chain is purified by standard chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 311-426 a.a.
• Description: Inhibins are dimeric peptide hormones produced by female ovarian granulose cells and male Sertoli cells as well as a variety of other tissues. Inhibins have two isoforms, A and B, with the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits. Inhibins are thought to inhibit the production of follicle-stimulating hormone (FSH) by the pituitary gland. In addition, Inhibins are also thought to play a role in the control of gametogenesis, and embryonic and fetal development.
• Physical Appearance: Sterile Filtered clear solution (0.185 mg/ml).
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: Activin-A is supplied in 20 mM Tris pH-8 and 50% glycerol.
• Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: INHBA inhibin, beta A [ Homo sapiens ]
• Synonyms: Activin beta-A chain, Erythroid differentiation protein, EDF, FRP, FSH-releasing protein, Inhibin, beta-1, erythroid differentiation factor, follicle-stimulating hormone-releasing protein, inhibin beta A, inhibin, beta A, inhibin, beta A (activin A, activin AB alpha polypeptide)
• Gene ID: 3624
• mRNA Refseq: NM_002192
• Protein Refseq: NP_002183
• MIM: 147290
• UniProt ID: P08476
• Chromosome Location: 7p15-p13
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: cytokine activity; follistatin binding; growth factor activity; hormone activity; identical protein binding; protein heterodimerization activity; signal transducer activity