irf3
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  • Official Full Name
  • interferon regulatory factor 3
  • Background
  • This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
  • Synonyms
  • IRF3; interferon regulatory factor 3;
Cat.#:IRF3-2146MTag:His|Myc
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IRF3 Protein (1-419 aa), His-Myc-tagged
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Cat.#:IRF3-5041HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF3 Protein, GST-tagged
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Cat.#:IRF3-27HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon Regulatory Factor 3
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Cat.#:IRF3-28273THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF3
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Cat.#:IRF3-60HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IRF3 protein, His-tagged
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Cat.#:IRF3-61HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF3 protein, His/T7-tagged
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Cat.#:IRF3-62HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF3 protein, His/sumo-tagged
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Cat.#:Irf3-7149MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irf3 protein, His & T7-tagged
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Cat.#:IRF3-8301MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRF3 Protein
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Cat.#:IRF3-2297RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF3 Protein, His-tagged
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Cat.#:IRF3-7262ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRF3
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Cat.#:IRF3-5166HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human IRF3 293 Cell Lysate
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Involved Pathway

IRF3 involved in several pathways and played different roles in them. We selected most pathways IRF3 participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Toll-like receptor signaling pathway
MAPK8B; TNF; STAT1A; PIK3R3; IFNA7; MAP2K4A; CXCL8B.3; IFNA2; CXCL10; MAP2K2
RIG-I-like receptor signaling pathway
IFNK; NFKB1; CXCL8B.3; IFNA12; TRAF2; IL12B; IL8L1; ATG12; NLRX1; MAPK14A
Cytosolic DNA-sensing pathway
CCL4; POLR3A; POLR2H; ADAR; IFNA12; NFKBIA; IKBKB; NFKBIAA; OSTN; POLR3H
Pertussis
IL23; GNAI3; C4BPA; RELA; ITGA5; ITGB1; IRAK4; ITGB2L; CALML3; C4BPB
Hepatitis C
TRADD; MAPK3; IRF9; TRP53; CLDN22; PPP2CB; IFNA1; PDPK1; IRF1; TP53
Hepatitis B
Casp3; IFNA8; EP300; CCND1; MAP3K1; PIK3CD; CCNA1; IFNA14; KRAS; BAD
Measles
IFNAR1; RAB9A; IFNAR2; OAS1B; STAT3; TP73; STAT2; PIK3R5; IFNA5; IL1A
Influenza A
NUP98; IFNG; CXCL8; PIK3R1; DDX39B; HLA-DQB1; PIK3R3; DDX58; PABPN1; TNFRSF10D
Herpes simplex infection
SRSF9; IFNA7; TRAF2; TP53; CASP3B; IFNGR1; HLA-DPA1; TAP2; OAS3; TAF13
Epstein-Barr virus infection
ENTPD1; PSMC3; NUP214; HLA-C; TRAF5; ENTPD8; PRKACG; PSMC4; IKBKB; AKT1
Viral carcinogenesis
GTF2A1; REL; HDAC1; HLA-E; HDAC10; HIST1H2BJ; IRF3; HIST1H4I; PKM2; PRKACG

Protein Function

IRF3 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF3 itself. We selected most functions IRF3 had, and list some proteins which have the same functions with IRF3. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HOMEZB; HEMK1; NR6A1; MCM3L; ATRX; ZFP260; PAX2A; ESR2A; C14orf43; NR2F5
Function identical protein binding
Related Protein GLUD1; SIAH1A; UHRF1; MVK; TRP63; FAM108A1; ITGA2B; CALCA; APOA1; USP15
Function protein binding
Related Protein OPRM1; MKRN3; GOLGA1; LTC4S; ITGAX; GCNT1; FBXO33; TNFRSF21; BLM; IFIH1
Function protein homodimerization activity
Related Protein SLK; PML; SNRPC; FLRT3; IZUMO1; ARID3A; MAPK4; COMMD1; HLCS; QDPR
Function regulatory region DNA binding
Related Protein IRF5; IRF6; NFKB1; IRF3; IRF8; IRF2A; IRF1B; IRF4A; HMGA2; IRF1A
Function transcription cofactor activity
Related Protein ZNF763; LDB1A; MED16; TADA2A; CREB1; KAT2B; NFE2L1; LDB1B; ZNF710A; TFDP2
Function transcription factor activity, sequence-specific DNA binding
Related Protein DBPB; NFYB; LCOR; HOXD4; CEBPB; BARX1; PPARAB; ZBTB11; ZFHX3; ZNF334

Interacting Protein

IRF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF3.
TBK1; CREBBP

IRF3 Related Articles

Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).
Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).

IRF3 Related Gene Family

Cytokines