ifngr2
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  • Official Full Name
  • interferon gamma receptor 2 (interferon gamma transducer 1)
  • Background
  • This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
  • Synonyms
  • IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1); AF-1; IFGR2; IFNGT1; interferon gamma receptor 2; IFN-gamma-R2; IFN-gamma receptor 2; interferon gamma transducer 1; interferon gamma receptor beta chain; interferon gamma receptor accessory factor 1; interferon gamma receptor accessory factor-1;
Cat.#:IFNGR2-1083HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNGR2 Protein, MYC/DDK-tagged
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Cat.#:IFNGR2-23HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNGR2, Fc Chimera
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Cat.#:IFNGR2-14083HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNGR2, GST-tagged
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Cat.#:IFNGR2-241HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IFNGR2
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Cat.#:IFNGR2-29421THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human IFNGR2, Fc-tagged
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Cat.#:Ifngr2-602MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Ifngr2 Protein, His-tagged
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Cat.#:Ifngr2-6955MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifngr2, His tagged
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Cat.#:IFNGR2-1861CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IFNGR2
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Cat.#:IFNGR2-1899MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IFNGR2 cell lysate
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Involved Pathway

IFNGR2 involved in several pathways and played different roles in them. We selected most pathways IFNGR2 participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
OSTN; CCL19B; LTA; TNFRSF12A; TNFRSF8; TGFB3; PDGFC; IFNA21; IL17B; PDGFB
HIF- signaling pathway
PDHB; SLC2A1; VEGFA; CAMK2B; TEK; Trf; TLR4; LTBR; HK3; VHL
Osteoclast differentiation
CYLD; SYK; TREM2; NFKB1; SPI1; TYK2; TGFBR2; OSCAR; SIRPB1; MAPK9
Jak-STAT signaling pathway
IL10RA; MCL1A; CRLF2; IL11RA; IL21; TSLP; SOCS5B; IL2RG; STAM2; Gh
Natural killer cell mediated cytotoxicity
TNFRSF10D; SOS1; KLRD1; KLRA8; TNF; CD247; Raet1c; PTPN11; PIK3R2; ARAF
Salmonella infection
WASLA; MAPK12; ROCK2A; CDC42L; TJP1; CDC42; TLR4BB; DYNC1I2A; RELA; RILP
Leishmaniasis
IFNG; FCGR2C; IL1A; CYBA; FCGR3A; MAPK1; TGFB1; ELK1; FOS; TAB2
Chagas disease (American trypanosomiasis)
GNAI1; CD3E; MAPK11; IL1B2; IFNG; PPP2CA; IFNGR1; FADD; PIK3R5; NFKB1
Toxoplasmosis
PIK3CG; PIK3CD; TLR2; NFKBIA; HSPA1L; HSPA8; MAP2K3; BIRC3; MAPK11; AKT1
Tuberculosis
HLA-DMA; FCGR2B; IFNGR2; ITGB2L; MAPK9; LAMP2; IFNA6; KSR1; CYCS; IL10RA
Measles
NFKBIA; CD209C; cgr2b; MX1; HSPA1L; IFNG; TRAF6; IFNA14; CD209B; TNFRSF10A
Influenza A
BCL2L2-PABPN1; IFNA4; RAE1; HLA-DPA1; ACTG1; PIK3R1; PABPN1L; HLA-DOB; MAP2K1; NFKBIA
Herpes simplex infection
IFNA13; CLOCKA; Casp3; SRPK1B; C5; HNRNPK; IL12B; HLA-DQA1; CSNK2A2A; EIF2AK2
Inflammatory bowel disease (IBD)
IL17F; TGFB3; GATA3; HLA-DRB5; HLA-DMB; HLA-DOA; Il4ra; STAT1; STAT4; TGFB2

Protein Function

IFNGR2 has several biochemical functions, for example, interferon-gamma receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNGR2 itself. We selected most functions IFNGR2 had, and list some proteins which have the same functions with IFNGR2. You can find most of the proteins on our site.
Function
Related Protein
Function interferon-gamma receptor activity
Related Protein IFNGR2; IFNGR1

IFNGR2 Related Gene Family

Cytokines