Active Recombinant Human IFNGR2 Protein

• Cat.No.: IFNGR2-265I
• Product Overview: Recombinant Human IFNGR2 Protein without tag was expressed in CHO.

Specification

• Description: IFN-gamma Receptor II, also known as IFNGR2 and IFNGT1, is a transmembrane protein belonging to the type II cytokine receptor family. IFNGR2 is a non-ligand-binding beta chain of the IFN-gamma receptor. It is an integral part of the IFN-gamma signaling transduction pathway and is likely to interact with GAF, JAK1 and JAK2. Defects in IFNGR2 are a cause of autosomal recessive Mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.
• Source: CHO
• Species: Human
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: ED50 < 0.1 μg/mL, measured in a cell cytotoxicity assay using HT-29 (HTB-38) cells in the presence of 1 ng/mL human IFN-gamma.
• Molecular Mass: 38-40 kDa, observed by reducing SDS-PAGE.
• AA Sequence: SQLPAPQHPKIRLYNAEQVLSWEPV ALSNSTRPVVYQVQFKYTDSKWFTA DIMSIGVNCTQITATECDFTAASPS AGFPMDFNVTLRLRAELGALHSAWV TMPWFQHYRNVTVGPPENIEVTPGE GSLIIRFSSPFDIADTSTAFFCYYV HYWEKGGIQQVKGPFRSNSISLDNL KPSRVYCLQVQAQLLWNKSNIFRVG HLSNISCYETMADASTELQQ
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 95% as analyzed by SDS-PAGE.
• Storage: Lyophilized recombinant Human IFN-gamma Receptor II remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human IFN-gamma Receptor II should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: IFNGR2 interferon gamma receptor 2 [ Homo sapiens (human) ]
• Official Symbol: IFNGR2
• Synonyms: IFNGR2; interferon gamma receptor 2; AF-1; IFGR2; IMD28; IFNGT1
• Gene ID: 3460
• mRNA Refseq: NM_005534
• Protein Refseq: NP_005525
• MIM: 147569
• UniProt ID: P38484